Secreted frizzled-related protein 4 (FRP-4)

The secreted frizzled-related protein family consists of five secreted glycoproteins which act as extracellular signaling ligands. Each is approximately 300aa in length and contains a cysteine- rich domain, homologous to the Wnt binding site of Frizzled proteins. sFRPs act as soluble modulators of Wnt signaling and may act as tumor suppressors. sFRP-4 protein levels were found to be elevated in serum several years before a Type 2 Diabetes clinical diagnosis. A mouse model suggests sFRP4 gene is related to islet inflammation and impaired insulin secretion, indicating sFRP4 could be a potential biomarker for islet dysfunction in T2D

Swiss-Prot Accession Number: Q6FHJ7

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This analyte is not currently part of Myriad RBM's testing menu.