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Inflammation and Immune Response
2023
Effect of pegbelfermin on NASH and fibrosis-related biomarkers and correlation with histological response in the FALCON 1 trial (2023) Elizabeth A. Brown, Anne Minnich, Arun J. Sanyal, Rohit Loomba, Shuyan Du, John Schwarz, Richard L. Ehman, Morten Karsdal, Diana J. Leeming, Giovanni Cizza, Edgar D. Charles
JHEP Reports
Urinary markers differentially associate with kidney inflammatory activity and chronicity measures in patients with lupus nephritis (2023) Ahmad Akhgar, Dominic Sinibaldi, Lingmin Zeng, Alton B Farris III, Jason Cobb, Monica Battle, David Chain, Jennifer A Cann, Gabor G Illei, S Sam Lim , Wendy I White
Lupis Science and Medicine
Inflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD (2023) Stefanie Lerche, Milan Zimmermann, Benjamin Roeben, Isabel Wurster, , Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Meike Jakobi, Thomas O. Joos, Thomas Knorpp, Nicole Schneiderhan-Marra and Kathrin Brockmann
Nature
Early and recent exposure to adversity, TLR-4 stimulated inflammation, and diurnal cortisol in women with interstitial cystitis/bladder pain syndrome: A MAPP research network study (2023) Susan K Lutgendorf, Sharaf Zia, Yi Luo, Michael O'Donnell, Adrie van Bokhoven, Catherine S Bradley, Robert Gallup, Jennifer Pierce, Bayley J Taple, Bruce D Naliboff, J Quentin Clemens, Karl J Kreder, Andrew Schrepf
Brain, Behavior, and Immunity
Focused ultrasound neuromodulation of the spleen activates an anti-inflammatory response in humans (2023) Stavros Zanos, Despoina Ntiloudi, John Pellerito, Richard Ramdeo, John Graf, Kirk Wallace, Victoria Cotero, Jeff Ashe, Jessica Moon, Meghan Addorisio, David Shoudy, Thomas R. Coleman, Michael Brines, Chris Puleo, Kevin J. Tracey, Sangeeta S. Chavan
Brain Stimulation
Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers–In cognitively unimpaired older adults (2023) Elettra Capogna, Leiv Otto Watne, Øystein Sørensen, Carlijn Jamila Guichelaar, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Piñeiro
Brain Behavior Immunology
Long-term in vivo vitamin D3 supplementation modulates bovine IL-1 and chemokine responses (2023) Cian Reid , Susana Flores-Villalva, Aude Remot, Emer Kennedy, Cliona O’Farrelly
Nature
Back To Top2022
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines (2022) Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, Lélia Delamarre & Ira Mellman
Nature Immunology
Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women (2022) Nardhy Gomez-Lopez, Roberto Romero, Li Tao, Meyer Gershater, Yaozhu Leng, Chengrui Zou, Marcelo Farias-Jofre, Jose Galaz, Derek Miller, Adi L. Tarca, Marcia Arenas-Hernandez, Gaurav Bhatti, Valeria Garcia-Flores, Zhenjie Liu, Robert Para, Tomi Kanninen, Ola Hadaya, Carmen Paredes and Yi Xu
Journal of Immunology
Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation (2022) Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Li Tao, Catherine Demery-Poulos, Marcia Arenas-Hernandez, Gaurav Bhatti, Zhenjie Liu, Naoki Kawahara, Tomi Kanninen, Zachary Shaffer, Tinnakorn Chaiworapongsa, Kevin R. Theis, Adi L. Tarca & Nardhy Gomez-Lopez
Inflammation Research
Defective type I interferon immunity is associated with increasing COVID-19 severity (2022) Nikaïa Smith, Céline Possémé, Vincent Bondet, Jamie Sugrue, Liam Townsend, Bruno Charbit, Vincent Rouilly, Violaine Saint-André, Tom Dott, Andre Rodriguez Pozo, Nader Yatim, Olivier Schwartz, Minerva Cervantes-Gonzales, Jade Ghosn, Paul Bastard, Jean Laurent Casanova, Tali-Anne Szwebel, Benjamin Terrier, Niall Conlonm, Cliona O’Farrelly, Clíona Ní Cheallaigh, Nollaig M Bourke, Darragh Duffy
Research Square
An Exploratory Analysis of Biomarkers of Perihematomal Edema in the CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial (2022) Jay B Lusk, Jesse Troy, Nathaniel Nowacki, Peter G Kranz, Maureen Maughan, Daniel T Laskowitz, Michael L James
Journal of Stroke and Cerebrovascular Diseases
Childhood trauma and LPS-stimulated inflammation in adulthood: Results from the Netherlands Study of Depression and Anxiety (2022) Ricki M.de Koning, Erika Kuzminskaite, Christiaan H.Vinkers, Erik J. Giltay, Brenda W.J.H.Penninx
Brain, Behavior, and Immunity
Anti-interleukin-6 Antibody Clazakizumab in Antibody-mediated Renal Allograft Rejection: Accumulation of Antibody-neutralized Interleukin-6 Without Signs of Proinflammatory Rebound Phenomena (2022) Anita Borski, Farsad Eskandary, Susanne Haindl, Konstantin Doberer, Jakob Mühlbacher, Katharina A Mayer, Klemens Budde, Philip F Halloran, Edward Chong, Bernd Jilma, Georg A Böhmig, Markus Wahrmann
Transplantation
CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-infammatory cytokine production (2022) Rajula Gaur, Kofi A Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik 1, Jamie Connarn 1, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ramírez-Valle
Arthritis Research and Therapy
Early stimulated immune responses predict clinical disease severity in hospitalized COVID-19 patients (2022) Rebecka Svanberg, Cameron MacPherson, Adrian Zucco, Rudi Agius, Tereza Faitova, Michael Asger Andersen, Caspar da Cunha-Bang, Lars Klingen Gjærde, Maria Elizabeth Engel Møller, Patrick Terrence Brooks, Birgitte Lindegaard, Adin Sejdic, Anne Ortved Gang, Ditte Stampe Hersby, Christian Brieghel, Susanne Dam Nielsen, Daria Podlekareva, Annemette Hald, Jakob Thaning Bay, Hanne Marquart, Jens Lundgren, Anne-Mette Lebech, Marie Helleberg, Carsten Utoft Niemann & Sisse Rye Ostrowski
Communications Medicine
Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction (2022) Upendra Chalise, Mediha Becirovic-Agic, Jocelyn R. Rodriguez-Paar, Shelby R. Konfrst, Sharon D. B. de Morais, Catherine S. Johnson, Elizabeth R. Flynn, Michael E. Hall, Daniel R. Anderson, Leah M. Cook, Kristine Y. DeLeon-Pennell & Merry L. Lindsey
Journal of Cardiovascular Translational Research
Exploration of the induced cytokine responses in European Lyme neuroborreliosis: A longitudinal cohort study (2022) Rosa Maja Møhring Gynthersen, Mathilde Orbaek, Helene Mens, Christian Stenor, Lothar Wiese, Sisse Rye Ostrowski, Susanne Dam Nielsen, Anne-Mette Lebech
Ticks and Tick-borne Diseases
Distinct Immune Reconstitution Profiles Captured by Immune Functional Assays at 6 Months Post Allogeneic Hematopoietic Stem Cell Transplantation (2022) William Mouton, Anne Conrad, Vincent Alcazer, Mathilde Boccard, Maxime Bodinier, Guy Oriol, Fabien Subtil, Helene Labussiere-Wallet, Sophie Ducastelle-Lepretre, Fiorenza Barraco, Marie Balsat, Gaelle Fossard, Karen Brengel-Pesce, Florence Adler, Sophie Trouillet-Assant
Transplantation and Cellular Therapy
First-in-human study of deucravacitinib: A selective, potent, allosteric small-molecule inhibitor of tyrosine kinase 2 (2022) Ian M Catlett, Urvi Aras, Lars Hansen, Yali Liu, Di Bei, Ihab G Girgis, Bindu Murthy
Clinical Translational Science
Autologous NK cells propagated and activated ex vivo decrease senescence markers in human PBMCs (2022) Nickolas Chelyapov, Toai T Nguyen, Rafael Gonzalez
Biochemistry and Biophysics Reports
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity (2022) Nikaïa Smith, Céline Possémé, Vincent Bondet, Jamie Sugrue, Liam Townsend, Bruno Charbit, Vincent Rouilly, Violaine Saint-André, Tom Dott, Andre Rodriguez Pozo, Nader Yatim, Olivier Schwartz, Minerva Cervantes-Gonzalez, Jade Ghosn, Paul Bastard, Jean Laurent Casanova, Tali-Anne Szwebel, Benjamin Terrier, Niall Conlon, Cliona O'Farrelly, Clíona Ní Cheallaigh, Nollaig M Bourke, Darragh Duffy
Nature Communciations
Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response (2022) Adam J. Walker, Mohammadreza Mohebbi, Michael Maes, Michael Berk, Ken Walder, Chiara C. Bortolasci, Zoe SJ. Liu, Chee H. Ng, Melanie M. Ashton, Lesley Berk, Ajeet B. Singh, Gin S. Malhi Olivia M. Dean
Brain, Behavior, & Immunity - Health
Back To Top2021
First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects (2021) Yang J, Lickliter JD, Hilson JL, Means GD, Sanderson RJ, Carley K, Tercero A, Manjarrez KL, Wiley JR, Peng SL
Clinical and Translational Science
Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response (2021) Aevermann B, Shannon CP, Novotny M, Ben-Othman R, Cai B, Zhang Y, Ye JC, Kobor MS, Gladish N, Lee A, Blimke TM, Hancock RE, Llibre A, Duffy D, Koff WC, Sadarangani M, Tebbutt SJ, Kollmann TR, Scheuermann RH
medRxiv
Novel signatures associated with systemic lupus erythematosus clinical response to IFN-a/-? inhibition (2021) Seridi L, Cesaroni M, Orillion A, Schreiter J, Chevrier M, Marciniak S, Migone TS, Stohl W, Chatham WW, Furie RA, Benson J, Jordan J
Lupus
Molecular correlates of response to nivolumab at baseline and on treatment in patients with RCC (2021) Ross-Macdonald P, Walsh AM, Chasalow SD, Ammar R, Papillon-Cavanagh S, Szabo pm, Choueiri TK, Sznol M, Wind-Rotolo M
Journal for Immunotherapy for Cancer
Primary human dendritic cells and whole-blood based assays to evaluate immuno-modulatory properties of heat-killed commensal bacteria (2021) Norton JE Jr., Kommineni S, Akrivoulis P, Gutierrez DA, Hazuda DJ, Swaminathan G
Vaccines
Differential response induced by LPS and MPLA in immunocompetent and septic individuals (2021) Vega CA, Karakike E, Bartolo F, Mouton W, Cerrato E, Brengel-Pesce K, Giamarellos-Bourboulis EJ, Mallet F, Trouillet-Assant S
Clinical Immunology
Characterization of the pathophysiological determinants of diarrheagenic Escherichia coli infection using a challenge model in healthy adults (2021) van Hoffen E, Mercenier A, Vidal K, Benyacoub J, Schloesser J, Kardinaal A, Lucas-van de Bos E, van Alen I, Rogero I, Duintjer K, Berendts A, Albers R, Kleerebezem M, Bruggencate ST
Scientific Reports
Development of an affordable, sustainable and efficacious plant-based immunomodulatory food ingredient based on bell pepper or carrot RG-I pectic polysaccharides (2021) McKay S, Oranje P, Helin J, Koek JH, Kreijveld E, van den Abbeele P, Phol u, Bothe G, Tzoumaki M, Aparicio-Vergara M
Nutrients
Functional immune reconstitution early after allogeneic hematopoietic cell transplantation: A comparison of pre- and post-transplantation cytokine responses in stimulated whole-blood (2021) Gjaerde LK, Brooks PT, Andersen NS, Friss LS, Kornblit B, Petersen SL, Schjodt I, Nielsen SD, Ostrowski SR, Sengelov H
Scandinavaian Journal of Immunology
Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1-2, dose-ranging study (2021) Goepfert PA, Fu B, Chabanon AL, Bonaparte MI, Davis MG, Essink BJ, Frank I, Haney O, Janosczyk H, Keefer MC, koutsoukos M, Kimmel MA, Masotti R, Savarino SJ, Schuerman L, Schwarts H, Sher LD, Smith J, Tavares-Da-Silva F, Gurunathan S, DiazGranados CA, de Bruyn G
The Lancet, Infectious Disease
Preclinical and clinical characterization of the ROR?t inhibitor JNJ-61803534 (2021) Xue X, De Leon-Tabaldo A, Luna-Roman R, Castro G, Albers M, Shoetens F, DePrimo S, Devineni D, Wilde T, Goldberg S, Hoffmann T, Fourie AM, Thurmond RL
Scientific Reports
The migration of human follicular dendritic cell-like cell is facilitated by matrix metalloproteinase 3 expression that is mediated through TNFa-ERK1/2-AP1 signaling (2021) Pak HK, Kim YW, Nam B, Lee AN, Roh J, Gil M, Liu C, Chung YS, Park CS
Journal of Immunology Research
Anti-interleukin-6 antibody clazakizumab in late antibody-mediated kidney transplant rejection: effect on cytochrome P450 drug metabolism (2021) Muhlbacher J, Schorgenhofer C, Doberer K, Durr M, Budde K, Eskandary F, Mayer KA, Schranza S, Ely S, Reiter B, Chong E, Adler SH, Jilma B, Bohmig GA
Transplant Internatinoal
Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming (2021) Hirschberger S, Straub G, Effinger D, Marstaller X, Ferstl A, Muller MB, Wu T, Hubner M, Rahmel T, Mascolo H, Exner N, Heb J, Kreth FW, Unger K, Kreth S
EMBO Molecular Medicine
NBAS variants are associated with quantitative and qualitative NK and B cell deficiency (2021) Lenz, D, Pahl J, Hauck F, Alameer S, Balasubramanian M, Baric I, Boy N, Church JA, Crushell E, Dick A, Distelmaier F, Gujar J, Indolfi G, Lurz E, Peters B, Schwerd T, Serranti D, Kolker S, Klein C, Hoffmann GF, Prokisch H, Greil J, Cerwenka A, Giese T Staufner C
Journal of Clinical Immunology
Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll-like receptors 7 and 8 (2021) Port A, Shaw JV, Klopp-Schulze L, Bytyqi A, Vetter C, Husey E, Mammasse N, Ona V, Bachmann A, Strugala D, Reh C, Goteti K
Pharmacology Researh and Perspective
Antitumor necrosis factor-like ligand 1A therapy targets tissue inflammation and fibrosis pathways and reduces gut pathobionts in ulcerative colitis (2021) Hassan-Zahraee M, Ye Z, Baniecki ML, Li X, Hyde CL, Zhang J, Raha N, Karlsson F, Quan J, Ziemek D, Neelakantan S, Lepsy C, Allegretti JR, Romatowski J, Scherl EJ, Klopocka M, Danese S, Chandra DE, Schoenbeck U, Vincent MS, Longman R,Hung KE
Inflammatory Bowl Diseases
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease (2021) Pierson SK, Shenoy S, Oromendia AB, Gorzewski AM, Pai RA, Nabel CS, Ruth JR, parente SAT, Arenas DJ, Guilfoyle M, Reddy MP, Weinblatt M, Shadick N, Bower M, Pria AD, Masaki Y, Katz L, Mezey J, Beineke P, Lee D, Tendler C, Kambayashi T, Fossa A, van Rhee F, Fajgenbaum DC
Blood Advances
A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis (2021) Alexander Jr LC, McHorse G, Huebner JL, Bay-Jensen AC, Karsdal MA, Kraus VB
Arthritis Research & Therapy
Distinct patterns of blood cytokines beyond a cytokine storm predict mortality in COVID-19 (2021) Herr C, Mang S, Mozafari B, Guenther K, Speer T, seibert M, Srikakulam SK, Beisswenger C, Ritzmann F, Keller A, Mueller R, smola S, Eisinger D, Zemlin M, Danziger G, Volk T, Hoersch S, Krawczyk M, Lammert F, Adams T, Wagenpfeil G, Kindermann M, Marcu C, Ataya ZWD, Mittag M, Schwarzkopf K, Custodis F, Grandt D, Schaefer H, Eltges K, Lepper PM, Bals R
Journal of Inflammation Research
Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome (2021) Perlin DS, Neil GA, Anderson C, Zafir-Lavie I, Raines S, Ware CF, Wilkins HJ
Journal of Clinical Investigation
Back To Top2020
Neuroinflammation trajectories precede cognitive impairment after experimental meningitis-evidence from an in vivo PET study. (2020) Giridharan VV, Collodel A, Generoso JS, Scaini G, Wassather R, Selvaraj S, Hasbun R, Dal-Pizzol F, Petronilho F, Barichello T
Journal of Neuroinflammation
Association of occupational exposures with ex vivo functional immune response in workers handling carbon nanotubes and nanofibers (2020) Schubauer-Berigan MK, Dahm MM, Toennis CA, Sammons DL, Eye T, Kodali V, Zeidler-Erdely PC, Erdely A
Nanotoxicology
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia (2020) Narayanan P, Curtis BR, Shen L, Schneider E, Tami JA, Paz S, Burel SA, Tai LJ, Machemer T, Kwoh TJ, Xia S, Shattil SJ, Witztum JL, Engelhardt JA, Henry SP, Monia BP, Hughes SG
Nucleic Acid Therapeutics
Fenebrutinib versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double-Blind, Phase II Trial (ANDES Study). (2020) Cohen S, Tuckwell K, Katsumoto TR, Zhao R, Galanter J, Lee C,, Rae J, Toth B, Ramamoorthi N, Hackney JA, Berman A, Damjanov N, Fedkov D, Jeka S, Chinn W, Townsend MJ, Morimoto AM, Genovese MC
Arthritis& Rheumatology
Systematic investigation of polyurethane biomaterial surface roughness on human immune responses in vitro (2020) Segan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H
BioMed Research International
Innate Immune Stimulation of Whole Blood Reveals IFN-1 Hyper-Responsiveness in Type 1 Diabetes (2020) Rodrigues KB, Dufort MJ, Llibre A, Speake C, Jubayer Rahman M, Bondet V, Quiel J, Linsley PS, Greenbaum CJ, Duffy D, Tarbell KV
Diabetologia
Comparison of host immune responses to LPS in human using an immune profiling panel, in vivo endotaxemia versus ex vivo stimulation (2020) Tawfik DM, Lankelma JM, Vachot L, Cerrato E, Pachot A, Wiersinga WJ, Textoris J
Scientific Reports
Inhibition of cytokine signaling by ruxolitinib and implactions for COVID-19 treatment (2020) Yeleswaram S, Smith P, Burn T, Covington M, Juvekar A, Li Y, Squier P, Langmuir P
Clinical Immunology
Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition (2020) Laino AS, Woods D, Vassallo M, Qian X, Tang H, Wind-Rotolo M, Weber J
Journal for ImmunoTherapy of Cancer
Towards standardization of immune functional assays (2020) Mouton W, Albert-Vega C, Boccard M, Bartolo F, Oriol G, Lopez J, Pachot A, Textoris J, Mallet F, Brengel-Pesce K, Trouillet-Assant S
Clinical Immunology
Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus (2020) Smith MA, Chiang CC, Zerrouki K, Rahman S, White W, Streicher K, Rees WA, Schiffenbauer A, Rider LG, Miller FW, Manna Z, Hasni S, Kaplan M, Siegel R, Sinibaldi D, Sanjuan MA, Casey KA
Scientific Reports
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitnes in old age (2020) Brigger D, Riether C, van Brummelen R, Mosher KI, Shiu A, Ding Z, Zbaren N, Gasser P, Guntern P, Yousef H, Castellano JM, Storni F, Graff-Radford N, Britschgi M, Grandgirard D, Hinterbrandner M, Siegrist M, Moullan N, Hofstetter W, Leib SL, Villiger PM, Auwerx J, Villeda SA, Wyss-Coray T, Noti M, Eggel A
Nature Metabolism
Preoperative TruCulture whole blood cytokine response predicts postoperative inflammation in pancreaticoduodenectomy patients - a pilot cohort study (2020) Aasvang EK, Pitter S, Hansen CP, Storkholm JH, Krohn PS, Burgdorf SK, Von Stemann JH, Lundgren JD, Nielsen SD, Kehlet H, Ostrowski SR
Scandinavian Journal of Immunology
Basal and LPS-stimulated inflammatory markers and the course of individual symptoms of depression (2020) van Eeden WA, van Hemert AM, Carlier IVE, Penninx BWJH, Fried EI, Schoevers R, Giltay EJ
Translational Psychiatry
Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study (2020) Genovese MC, Gaylis NB, Sikes D, Kivitz A, Horowitz DL, Peterfy C, Glass EV, Levine YA, Chernoff D
The Lancet Rheumatology
Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration (2020) Lashkari K, Teague GC, Beattie U, Betts J,Kumar S, McLaughlin MM, Lopez FJ
PLOS One
Model informed dosing regimen and phase I results of the anti-PD-1 antibody budigalimab (ABBV-181) (2020) Powderly J, Spira A, Kondo S, Doi T, Luke JL, Rasco D, Gao B, Tanner M, Cassier PA, Gazzah A, Italiano A, Tosi D, Afar DE, Parikh A, Engelhardt B, Englert S, Lambert SL, Kasichayanula S, Mensing S, Menon R, Vosganian G, Tolcher A
Clinical and Translational Science
Molecular biomarkers of anti-TNF response in patients with rheumatoid arthritis (2020) Yoosuf N, Maciejewski M, Ziemek D, Jelinsky S, Folkersen, Muller M, Sahlstrom P, Vivar N, Catrina A, Berg L, Klareskog L, Padyukov L, Brynedal B
Arthritis Research & Therapy
Modulation of cardiometabolic disease markers by type I interferon inhibition in systemic lupus erythematosus (2020) Casey KA, Smith MA, Sinibaldi D, Seto NL, Playford MP, Wang X, Carlucci PM, Wang L, Illei G, Yu B, Wang S, Remaley AT, Mehta NH, Kaplan MJ, White WI
Arthritis Rheumatology
Inflammatory pathway analytes predicting rapid cognitive decline in MCI stage of Alzheimer's disease (2020) Pillai JA, Bena J, Bebek Gurkan, Bekris LM, Bonner-Jackson A, Kou L, Pai A, Sorensen L, Neilsen M, Rao SM, Chance M, Lamb BT, Leverenz JB, Alzheimer's Disease Neuroimaging Initiative
Annals of Clinical and Translational Neurology
Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab - a study protocol (2020) Takeshi N, Kenji I, Daisuke O, Satoshi N, Risa TM, Koji M, Susumu I, Hidehisa S, Yudai K, Riichiro A, Mamitaro O, Koji K, Tatsuro O, Tomomitsu M, Yozo I, Akihiko a, Hiroshi K, Keiji T, Hiroshi M, Tatsuyoshi K, Takuya T, Masashi A, Emi N, Akimchi M, Kyoko t, Yukinobu N, Koji S, Chicharu T, YOko K, Rai F, Sakae K, Eishin M, Akio T, Mchihiro H, Natsuko A, Shigetoshi S, Haruna M, Yutaka H, Motoi T, Hiroyuki M, Norito K, Masutaka F
Medicine
Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study (2020) Albert Vega C, Oriol G, Bartolo F, Lopez J, Pachot A, Rimmele T, Venet F, Leray V, Monneret G, Delwarde B, Brengel-Pesce K, Textoris J, Mallet F, Trouillet-Assant S
Scientific Reports
Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial (2020) Aranow C, Atish-Fregoso Y, Lesser M, Mackay M, Anderson E, Chavan S, Zanos TP, Datta-Chaundhuri T, Bouton C, Tracey KJ, Diamond B
Annals of the rheumatic diseases
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo (2020) Menegatti S, Guillemot V, Latis E, Yahia-Cherbal H, Mittermuller D, Rouilly V, Mascia E, Rosine N, Koturan S, Millot G, Leloup C, Duffy D, Gleizes A, Hacein-Bey-Abina S, Milieu interieur Consortium, Sellam J, Berenbaum F, Miceli C, Dougados M, Bianchi E, Rogge L
Ann Rheum Dis
Characterization of LY2775240, a selective phosphodiesterase-4 inhibitor, in nonclinical models and in healthy subjects (2020) Patel DR, Urva S, Ho S, Buckman CJ, Ma Y, Lim J, Sissons SE, Zuniga MS, Philips D, Cox K, Dairaghi D
Clinical and Translational Science
Systems biology methods applied to blood and tissue for comprehensive analysis of immune response to hepatitis B vaccine in adults (2020) Ben-Othman R, Cai B, Liu AC, Varankovich N, He D, Blimkie TM, Lee AH, Gill EE, Novotny M, Aevermann B, Drissler s, Shannon CP, McCann S, Marty K, Bjornson G, Edgar RD, Lin DTS, Gladish N, MacIsaac J, Amenyogbe N, Chan Q, Libre A, Collin J, Landais, E, Le K, Reiss SM, Koff WC, Havenar-Daughton C, Heran M, Sangha B, Walt D, Krajden M, Crotty S, Sok D, Briney B, Burton DR, Duffy D, Foster LJ, Mohn WW, Kobor MS, Tebbutt SJ, Brinkman RR, Scheuermann RH, Hancock REW, Kollmann TR, Sadarangani M
Frontiers in Immunology
Back To Top2019
Metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis (2019) Gautam A, Muhie S, Cakraborty N, Hoke A, Donohue D, Miller SA, Hammamieh R, Jett M
Metabolomics
Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases (2019) Sridhar S, Liu H, Damera G, Newbold P
Respiratory Research
VaccHemInf Project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients (2019) Conrad A, Boccard M, Valour F, Alcazer V, Tovar Sanchez AT, Chidiac C, Laurent F, Vanhems P, Salles G, Brengel-Pesce K, Meunier B, Trouillet-Assant S, Ader F, Lyyon HEMINF Study Group
BMJ Journals
Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques (2019) Sanz J, Maurizio PL, Snyder-Mackler N, Simons ND, Voyles T, Kohn J, Michopoulos V, Wilson M, Tung J, Barreiro LB
bioRxiv
Inflammatory parameters associated with systemic reactogenicity following vaccinatino with adjuvanted hepatitis B vaccines in humans (2019) Burny W, Marchant A, Herve C, Callegaro A, Caubet M, Fissette L, Gheyle L, Legrand C, Ndour C, Tavares Da Silva F, van der Most R, Willems F, Didierlaurent AM, Yarzabal J, ECR-008 study group
Vaccine
Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak (2019) Gramaglia I, Velez J, Chang YS, Caparros-Wanderley W, Combes V, Grau G, Stins MF, van der Heyde HC
PLoS One
Biomarkers of Community-Acquired Pneumonia: A Key to Disease Diagnosis and Management (2019) Savvateeva EN, Rubina AY, Gryadunov DA
BioMed Research International
VEGF-A from Granuloma Macrophages Regulates Granulomatous Inflammation by a Non-angiogenic Pathway during Mycobacterial Infection (2019) Harding JS, Herbath M, Chen Y, Rayasam A, Ritter A, Csoka B, Hasko G, Michael IP, Faby Z, Nagy A, Sandor M
Cell Reports
Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation. (2019) Haraden CA, Huebner JL, Hsueh MF, Li YJ, Kraus VB
Arthritis Research & Therapy
Immune function as predictor of infectious complications and clinical outcome in patients undergoing solid organ transplantation (the ImmuneMo:SOT study): a prospective non-interventional observational trial. (2019) Drabe CH, Sorensen SS, Rasmussen A, Perch M, Gustafsson F, Rezahosseini O, Lundgren JD, Osrowski SR, Nielson SD
BMC Infectious Diseases
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. (2019) Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z, Lim SO , Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y, Nie L, Hsu JL, Li H, Ye Q, Hassan MM, Amin HM, Kaseb AO, Lin X, Wang SC, Hung MC
The Journal of Clinical Investigation
T cell phenotypes are associated with serum IgE levels in Amish and Hutterite children (2019) Hrusch CL, Stein MM, Gozdz J, Holbreich M, Von Mutius E, Vercelli D, Ober C, Sperling AI
Journal of Allergy and Clinical Immunology
The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation. (2019) Leiter O, Bernas SN, Seidemann S, Overall RW, Horenburg C, Kowal S, Kempermann G, Walker TL
Scientific Reports
Innate Immune Cells and C-Reactive Protein in Acute First-Episode Psychosis and Schizophrenia: Relationship to Psychopathology and Treatment (2019) Steiner J, Frodl T, Schiltz K, Dobrowolny H, Jacobs R, Fernandes BS, Guest PC, Meyer-Lotz G, Borucki K, Bahn S, Bogerts B, Falkai P, Bernstein HG
Schizophrenia Bulletin
Apremilast Mechanism of Efficacy in Systemic-Naive Patients With Moderate Plaque Psoriasis: Pharmacodynamic Results From the UNVEIL Study (2019) Strober B, Alikhan A, Lockshin B, Shi R, Cirulli J, Schafer P
Journal of Dermatological Science
Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab. (2019) Hotchkiss RS, Colston E, Yende S, Crouser ED, Martin GS, Alberson T, Bartz RR, Brakenridge SC, Delano MJ, Park PK, Donnino MW, Tidswell M, Mayr FB, Angus DC, Coopersmith CM, Moldawer LL, Catlett IM, Girgis IG, Ye J, Grasela DM
Intensive Care Med
Functional immune monitoring in severely injured patients - a pilot study. (2019) Halbgebauer R, Kllermann S, Schafer F, Weckbach S, Weiss M, Barth E, Bracht H, Kalbitz M, Gebhard F, Huber-Lang MS, Perl M
Scandinavian Journal of Immunology
Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study. (2019) Schafer PH, Kivitz AJ, Ma J, Korish S, Sutherland D, Li L, Azaryan A, Kosek J, Adams M, Capone L, Hur EM, Hough DR, Ringheim GE
Rheumatology and Therapy
Back To Top2018
A Multi-site In-depth Evaluation of the Qunaterix Simoa from a User's Perspective (2018) Chunyk A, Joyce A, Fischer S, Dysinger M, Mikulskis A, Jeromin A, Lawrence-Henderson R, Baker D, Yeung D
The AAPS Journal 2018
Comparison of a microsphere-based platform with a multiplex flow cytometric assay for determination of circulating cytokines in the mouse (2018) Stricker-Krongrad A, Shoemake C, Zhong M, Liu J, Bouchard G
BMC Clinical Pathology Jan 2018
Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury (2018) Proudfood A, Bayliffe A, O'Kane C, Wright T, Serone A, Bareille P, Brown V, Hamid U, Chen Y, Wilson R, Cordy J, Morley P, de Wildt Ruud, Elborn S, Hind M, Chilvres E, Griffiths M, Summers C, McAuley D
Thorax
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A
PLoS One
Embelin and its derivatives unravel the signaling, proin?ammatoryand antiatherogenic properties of GPR84 receptor (2018) Gaidarov I, Anthony T, Gatlin J, Chen X, Mills D, Solomon M, Han S, Semple G, Unett DJ
Pharmacological Research
S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome (2018) Wang L, Rose CD, Foley KP, Anton J, Bader-Meunier B, Brissaud P, Chedeville G, Cimaz R, Fernandez-Martin J, Guly C, Hachulla E, Harjacek M, Mackensen F, Merino R, Modesto C, Hernandez A, Pajot C, Ramanan A, Thatayatikom A, Thomee C, Vastert S, Votta B, Bertin J, Wouters CH
Rheumatology
Toxoplasma gondii inactivates human plasmacytoid dendritic cells by functional mimicry of IL-10 (2018) Piotr L, Zhao Y, Singh S, Dai J, Yap GS, Fitzgerald-Bocarsly P
The Journal of Immunology
Carbon nanotube and nanofiber exposure and sputum and blood biomarkers of early effect among U.S. workers (2018) Beard JD, Erdely A, Dahm MM, de Perio MA, Birch ME, Evans DE, Fernback JE, Eye T, Kodali V, Mercer RR, Bertke SJ, Schubauer-Berigan MK
Environmental Internation 116 (2018)
Evaluation of plasma biomarkers of inflammation in patients with maple syrup urine disease (2018) Scaini G, Tonon T, Moura de Souza CF, Schuck PF, Ferreira GC, Quevedo J, Seda Neto J, Amorim T, Camelo Jr JS, Vitoria Barban Margutti A, Hencke Tresbach R, Sperb-Ludwig F, Boy R, V. de Medeiros PF, Schwards IVD, Luiz Streck E
Journal of Inherited Metabolic Disease
Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study (2018) Andersen M, Boesen M, Ellegaard K, Soderstrom K, Soe NH, Spee P, Morch UGW, Torp-Pedersen S, Bartels EM, Danneskiold-Samsoe B, Karlsson L, Bliddal H
Plos One
Cereblon modulator iberdomide induces degradation of the transcription factor Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus (2018) Schafer PH, Ye Y, Wu L, Kosek J, Ringheim G, Yang Z, Liu L, Thomas M, Palmisano M, Chopra R
Ann Rheum Dis
Effects of an FcyRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies (2018) Stein MM, Hrusch CL, Sperling AI, Ober C
Genes and Immunity
Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project (2018) Vonaesch P, Randremanana R, Gody JC, Collard JM, Giles-Vernick T, Doria M, Vigan-Womas I, Rubbo PA, Etienne A, Andriatahirintsoa EJ, Kapel N, Brown E, Huus KE, Duffy D, Finlay BB, Hasan M, Hunald FA, Robinson A, Manirakiza A, Wegener-Parfrey L, Vray M, Sansonetti PJ
BMC Pediatrics
Association between Cytokines and Functional, Hemodynamic Parameters, and Clinical Outcomes in Pulmonary Arterial Hypertension (2018) Joshi AA, Davey RA, Rao Y, Shen K, Benza R, Raina A
Pulmonary Circulation
Testing a multivariate proteomic panel for TBI biomarker discovery: A track-TBI pilot study (2018) Huie JR, Diaz-Arrastia R, Yue JK, Sorani M, Puccio A, Okonkwo DO, Manley GT, Ferguson AR
Journal of Neurotrauma
Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrom (2018) Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A
American Journal of Respiratory and Critical Care Medicine
Altered regulation of the T-cell system in patients with CRPS (2018) Heyn J, Azad SC, Luchting B
Inflammation Research
Identifying the molecular and cellular signature of cardiac dilation following myocardial infarction (2018) Lindsey ML, Ma Y, Flynn ER, Winniford MD, Hall ME, DeLeon-Pennell KY
BBA - Molecular Basis of Disease
Phase I/II trial of combination of anti-CD3/CD7 immunotoxins for steroid-refractory acute graft-versus-host disease (2018) Groth C, van Groningen LFJ, Matos TR, Bremmers ME, Preijers FWMB, Dolstra H, Reicherts C, Schaap NPM, van Hooren EHG, IntHout J, Masereeuw R, Netea MG, Levine JE, Morales G, Ferrara JL, Blijlevens NMA, van Oosterhout YVJM, Stelljes M, van der Velden WJFM
Biology of Blood and Marrow Transplantation
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients (2018) Naing A, Infante JR, Papadopoulos KP, Chan IH, Shen C, Ratti NP, Autio KA, Wong DJ, Patel MR, Ott PA, Falchook GS, Pant S, Hung A, Pekarek KL, Wu V, Adamow M, McCauley S, Mumm JB, Wong P, Van Vlasselaer P, Levegue J, Tannir NM, Oft M
Cancer Cell
Elevated circulating MMP-9 is linked to increased COPD exacerbation in SPIROMICS and COPDGene (2018) Wells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R 3rd, O'Neal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr RG, Woodruff P, Castaldi PJ, Gaggar A
JCI Insight
Association of baseline inflammatory markers and the development of negative symptoms in individuals at clinical high risk for psychosis (2018) Goldsmith DR, Haroon E, Miller AH, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Mathalon D, McGlashan T, Seidman L, Tsunag M, Woods SW, Walker EF, Perkins DO
Brain, Behavior, and Immunity
Serum Apolipoprotein E and Other Inflammatory Markers Can Identify Non-Responding Patients to a Dendritic Cell Vaccine (2018) Leeman H, Kaminska E, Green D, Bodman-Smith M, Gravett A, Bodman-Smith K, Copier J, Coulton G, Fusi A, Dalgleish AG
Translational Oncology
Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort (2018) Bhatt SP, Nath HP, Kim YI, Ramachandran R, Watts JR, Terry NLJ, Sonavane S, Deshmane SP, Woodruff PG, Oelsner EC, Bodduluri S, Han MK, Labaki WW, Michael Wells J, Martinez FJ, Barr RG, Dransfield MT, SPIROMICS investigators
Respiratory Research
Back To Top2017
Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease (2017) Brockmann K, Schulte C, Schneiderhan-Marra N, Apel A, Pont-Sunyer C, Vilas D, Ruiz-Martinez J, Langkamp M, Corvol JC, Cormier F, Knorpp T, Joos TO, Bernard A, Gasser T, Marras C, Schule B, Aasly JO, Foroud T, Marti-Masso JF, Brice A, Tolosa E, Berg D, Maetzler W.
Eur J Neurol
Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients. (2017) Luchting B, Hinske LC, Rachinger-Adam B, Celi LA, Kreth S, Azad SC
Biomark Med
Effects of Traumeel (Tr14) on recovery and inflammatory immune response after repeated bouts of exercise: a double-blind RCT. (2017) Muders K, Pilat C, Deuster V, Frech T, Krüger K, Pons-Kuhnemann J, Mooren FC
Eur J Appl Physiol.
Impact of Maternal antibodies and infant gut microbiota on the immunogenicity of rotacirus vaccines in African, Indian, and European infants: protocol for a prospective cohort study. (2017) Sindhu KN, Cunliffe N, Peak M, Turner M, Darby A, Grassly N, Gordon M, Dube Q, Babji S, Praharaj I, Verghese V, Iturriza-Gomara M, Kang G
BMJ
Immunodepression after CPB: Cytokine dynamics and clinics after pediatric cardiac surgery – A prospective trial (2017) Justus G, Walker C, Rosenthal LM, Berger F, Miera O, Schmitt KR
Cytokine
The REAnimation Low Immune Status Markers (REALISM) project: a protocol for broad characterisation and follow-up of injury-induced immunosuppression in intensive care unit (ICU) critically ill patients (2017) Rol ML, Venet F, Rimmele T, Moucadel V, Cortez P, Quemeneur L, Gardiner D, Griffiths A, Pachot A, Textoris J, Monneret G, On behalf of the REALISM study group
BMJ Open
The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden. CETP mice (2017) Landlinger C, Pouwer MG, Juno C, van der Hoorn J, Pieterman EJ, Jukema JW, Staffler G, Princen H, and Galabova, G
Eur. Heart J.
Vitamin D-deficiency and sex-specific dysregulation of placental inflammation (2017) Liu NQ, Larner DP, Yao Q, Chun RF, Ouyang Y, Zhou R, Tamblyn JA, Wagner CL, Hewison M
J Steroid Biochem Mol Biol.
Prophylactic Treatment with Cerium Oxide Nanoparticles Attenuate Hepatic Ischemia Reperfusion Injury in Sprague Dawley Rats. (2017) Manne NDPK, Arvapalli R, Graffeo VA, Bandarupalli VVK, Shokuhfar T, Patel S, Rice KM, Ginjupalli GK, Blough ER
Cell Physiol Biochem
Effect of DHA supplementation on oxylipin levels in plasma and immune cell stimulated blood. (2017) Schuchardt JP, Ostermann AI, Stork L, Fritzsch S, Kohrs H, Greupner T, Hahn A, Schebb NH
Prostaglandins Leukot Essent Fatty Acids
Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints. (2017) Phillips B, Titz B, Kogel U, Sharma D, Leroy P, Xiang Y, Vuillaume G, Lebrun S, Sciuscio D2, Ho J, Nury C2, Guedj E, Elamin A, Esposito M, Krishnan S, Schlage WK, Veljkovic E, Ivanov NV, Martin F, Peitsch MC, Hoeng J, Vanscheeuwijck P
Food Chem Toxicol.
Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study (2017) Duffy D, Rouilly V, Braudeau C, Corbière V, Djebali R, Ungeheuer MN, Josien R, LaBrie ST, Lantz O, Louis D, Martinez-Caceres E, Mascart F, Ruiz de Morales JG, Ottone C, Redjah L, Guen N, Savenay A, Schmolz M, Toubert A, Albert ML
Clin Immunol
Changes in IL-17A, macrophage-derived chemokine and adiponectin following treatment of psoriasis with calcipotriol plus betamethasone dipropionate aerosol foam: results from the PSO-ABLE study. (2017) Røpke M, Bulai Livideanu C, Kaldate R, Snel A, Paul C
Br J Dermatol.
Altered Immune Activation and IL-23 Signaling in Response to Candida albicans in Autoimmune Polyendocrine Syndrome Type 1 (2017) Bruserud O, Bratland E, Hellesen A, Delaleu N, Reikvam H, Oftedal BE, and Wolff A
Front Immunol.
Inflammatory proteins in nasal lavage of workers exposed to occupational agents. (2017) Castano R, Yucesoy B, Johnson VJ, Castellanos L, Cartier A
Clin Exp Allergy
Exercise training reverses inflammation and muscle wasting after tobacco smoke exposure. (2017) Krüger K, Seimetz M, Ringseis R, Wilhelm J, Pichl A, Couturier A, Eder K, Weissmann N, Mooren FC
Am J Physiol Regul Integr Comp Physiol.
Randomized clinical study of safety, pharmacokinetics, andpharmacodynamics of RIPK1 inhibitor GSK2982772 in healthyvolunteers (2017) Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JE, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang M
Pharmacol Res Perspect.
Biosynthesis of cerium oxide nanoparticles and their effect on lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction in male Sprague Dawley rats. (2017) Chen G, Xu Y
Mater Sci Eng C Mater Biol Appl.
The role of anxious distress in immune dysregulation in patients with major depressive disorder. (2017) Gaspersz R, Lamers F, Wittenberg G, Beekman ATF, van Hemert AM, Schoevers RA, Penninx BWJH
Transl Psychiatry
Inflammatory profile analysis reveals differences in cytokine expression between smokers, moist snuff users, and dual users compared to non-tobacco consumers. (2017) Sgambato JA, Jones BA, Caraway JW, Prasad GL
Cytokine
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. (2017) Steggerda SM, Bennett MK, Chen J, Emberley E, Huang T, Janes JR, Li W, MacKinnon AL, Makkouk A, Marguier G, Murray PJ, Neou S, Pan A, Parlati F, Rodriguez MLM, Van de Velde LA, Wang T, Works M, Zhang J, Zhang W, Gross MI
J Immunother Cancer
The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia. (2017) Quiros-Roldan E, Castelli F, Lanza P, Pezzoli C, Vezzoli M; Inflammation in HIV Study Group, Biasiotto G, Zanella I
J Transl Med.
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges. (2017) Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L, Milieu Intérieur Consortium
Proc Natl Acad Sci U S A
Back To Top2016
Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant (2016) Felsky D, De Jager PL, Schneider JA, Arfanakis K, Fleischman DA, Arvanitakis Z, Honer WG, Pouget JG, Mizrahi R, Pollock BG, Kennedy JL, Bennett DA, Voineskos AN
J Cereb Blood Flow Metab
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits (2016) Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Holtzman D, Morris JC, Bales K, Pickering EH, Lee J, Heitsch L, Kauwe J, Goate A, Piccio L, Cruchaga C
Scientific Reports
Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination (2016) Fourati S, Cristescu R, Loboda A, Talla A, Filali A, Railkar R, Schaeffer AK, Favre D, Gagnon D, Peretz Y, Wang IM, Beals CR, Casimiro DR, Carayannopoulos LN, Sékaly RP
Nat Commun. 2016 Jan 8;7:10369
Dynamic Macrophage Polarization-Specific miRNA Patterns Reveal Increased Soluble VEGF Receptor 1 by miR-125a-5p Inhibition. (2016) Melton DW, Lei XF, Gelfond JAL, Shireman PK
Physiological Genomics
1. Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia (2016) Jondle CN, Sharma A, Simonson TJ, Larson B, Mishra BB, Sharma J
Journal of Immunology
A Sputum Proteomic Signature That Associates with Increased Il-1? Levels and Bacterial Exacerbations of COPD (2016) Damera G, Pham T-H, Zhang J, Ward CK, Newbold P, Ranade K, Sethi S
Lung
Noninvasive Transcutaneous Vagus Nerve Stimulation Decreases Whole Blood Culture-Derived Cytokines and Chemokines: A Randomized, Blinded, Healthy Control Pilot Trial (2016) Lerman I, Hauger R, Sorkin L, Proudfoot J, Davis B, Huang A, Lam K, Simon B, Baker DG
Neuromodulation: Technology at the Neural Interface
A Novel Approach for Emerging and Antibiotic Resistant Infections: Innate Defense Regulators as an Agnostic Therapy (2016) North JR, Takenaka S, Rozek A, Kielczewska A, Opal S, Morici LA, Finlay BB, Schaber CJ, Straube R, Donini O
Journal of Biotechnology
Effects of Repeated Complement Activation Associated with Chronic Treatment of Cynomolgus Monkeys with 2'-O-Methoxyethyl Modified Antisense Oligonucleotide (2016) Shen L, Engelhardt JA, Hung G, Yee J, Kikkawa R, Matson J, Tayefeh B, Machemer T, Giclas PC, Henry SP
Nucleic Acid Therapeutics
Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT (2016) Muders K, Pilat C, Deuster V, Frech T, Kruger K, Pons-Kuhnemann J, Mooren F-C
Mediators of Inflammation
Characterizing the Inflammatory Response in Esophageal Mucosal Biopsies in Children with Eosinophilic Esophagitis (2016) Sayej WN, Menoret A, Maharjan AS, Fernandez M, Wang Z, Balarezo F, Hyams JS, Sylvester FA, Vella AT
Clinical & Translational Immunology
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children (2016) Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, Von Mutius E, Vercelli D, Ober C, Sperling AI
New England Journal of Medicine
Pathogen and Host Response Dynamics in a Mouse Model of Borrelia hermsii Relapsing Fever (2016) Crowder CD, Langeroudi AG, Estabragh AS, Lewis ERG, Marcsisin RA, Barbour AG
Veterinary Sciences
Primary Analysis Of A Phase II Open-Label Trial Of INCB039110, A Selective JAK1 Inhibitor, In Patients With Myelofibrosis (2016) Mascarenhas JO, Talpaz M, Gupta V, Foltz LM, Savona MR, Paquette R, Turner AR, Coughlin P, Winton E, Burn TC, O'Neill P, Clark J, Hunter D10, Assad A, Hoffman R, Verstovsek S
Haematologica
Social status alters immune regulation and response to infection in macaques (2016) Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J
Science
Exercise-induced cytokine changes in antigen stimulated whole-blood cultures compared to serum (2016) Pilat C, Krüger K, Frech T, Mooren FC
J Immunol Methods.
Differential expression of P2X7 receptor and IL-1ß in nociceptive and neuropathic pain. (2016) Luchting B, Heyn J, Woehrle T, Rachinger-Adam B, Kreth S, Hinske LC, Azad SC
J Neuroinflammation
Back To Top2015
The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results From a Phase 3, Randomized, Placebo-Controlled Trial (PALACE 1). (2015) Schafer P, Chen P, Fang L, Wang A, Chopra R.
J Immunol Res 2015 Jan 10 [Epub ahead of print]
Acute and chronic plasma metabolomic and liver transcriptomic stress effects in a mouse model with features of post-traumatic stress disorder. (2015) Gautam A, D'Arpa P, Donohue DE, Muhie S, Chakraborty N, Luke BT, Grapov D, Carroll EE, Meyerhoff JL, Hammamieh R, Jett M.
PLoS One. 2015 Jan 28;10(1):e0117092. doi: 10.1371/journal.pone.0117092. eCollection 2015.
A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product. (2015) Phillips B, Veljkovic E, Peck MJ, Buettner A, Elamin A, Guedj E, Vuillaume G, Ivanov NV, Martin F, Bouéb S, Schlage WK, Schneider T, Titz B, Talikka M, Vanscheeuwijck P, Hoeng J, Peitsch MC.
Food Chem Toxicol. 2015 Apr 2. pii: S0278-6915(15)00088-5. doi: 10.1016/j.fct.2015.03.009. [Epub ahead of print]
Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model. (2015) Atkinson SM, Nansen A, Usher PA, Sondergaard BC, Mackay CR, Friedrichsen B, Chang CC, Tang R, Skov S, Haase C, Hornum L.
Autoimmunity. 2015 Apr 27:1-11. [Epub ahead of print]
Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of TNF-a receptor 1 (2015) Cordy JC, Morley PJ, Wright TJ, Birchler MA, Lewis AP, Emmins R, Chen YZ, Powley WM, Bareille PJ, Wilson R, Tonkyn J, Bayliffe AI, Lazaar AL.
Clin Exp Immunol.
Late Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337) (2015) Dietsch GN, Randall TD, Gottardo R, Northfelt DW, Ramanathan RK, Cohen PA, Manjarrez KL, Newkirk M, Bryan JK, Hershberg RM
Clinical Cancer Research
A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis (2015) Pardanani A, Tefferi A, Jamieson C, Gabrail NY, Lebedinsky C, Gao G, Liu F, Xu C, Cao H and Talpaz M
Blood Cancer Journal
THU0223 Serum Biomarkers Associated with Changes in Asdas and MRI Following Treatment of Ankylosing Spondylitis with Golimumab (2015) Inman RD, Baraliakos X, Hermann KG, Braun J, Deodhar A, van der Heijde DF, Xu S, Hsu B
Ann Rheum Dis
Identification of plasma biomarker concentration changes resulting from the administration of the Vascular Disrupting Agent BNC105 across 3 clinical trials in mesothelioma, ovarian and renal cancer (2015) Kremmidiotis G, Leske A, Simpson J, Doolin E, Iglesias J
AACR 2015
Biomarker results from a clinical trial of nivolumab in patients (pts) with metastatic renal cell carcinoma (mRCC) (CA209-009): Gene expression, serum profiling for immune markers, and multiplex tissue immunohistochemistry (IHC) (2015) Choueiri TK, Fishman MN, Escudier B, Stadler WM, Chasalow S, Ross-Macdonald P, Jure-Kunkel M, Sznol M, and Simon JS
Cancer Res
Novel data-mining approach identifies biomarkers for diagnosis of Kawasaki disease (2015) Tremoulet AH, Dutkowski J, Sato Y, Kanegaye JT, Ling XB, Burns JC
Pediatr Res.
Common Effects on Cancer Cells Exerted by a Random Positioning Machine and a 2D Clinostat (2015) Svejgaard B, Wehland M, Ma X, Kopp S, Sahana J, Warnke E, Aleshcheva G, Hemmersbach R, Hauslage J, Grosse J, Bauer J, Corydon TJ, Islam T, Infanger M, Grimm D
PLoS One
Multianalyte markers of schizophrenia and bipolar disorder: A preliminary study. (2015) Dickerson F, Schroeder J, Stallings C, Origoni A, Bahn S, Yolken R
Schizophr Res.
PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation. (2015) Adage T, Del Bene F, Fiorentini F, Doornbos RP, Zankl C, Bartley MR, Kungl AJ
Cytokine
Therapeutic Potential of Cerium Oxide Nanoparticles for the Treatment of Peritonitis Induced by Polymicrobial Insult in Sprague-Dawley Rats. (2015) Manne ND, Arvapalli R, Nepal N, Thulluri S, Selvaraj V, Shokuhfar T, He K, Rice KM, Asano S, Maheshwari M, Blough ER
Crit Care Med.
A Phase 1 Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma (2015) Amaravadi RK, Schilder RJ, Martin LP, Levin M, Graham MA, Weng DE, Adjei AA
Mol Cancer Ther.
Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice (2015) Mardare C, Krüger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC
J Diabetes Res
Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia (2015) Tomasik J, Schultz TL, Kluge W, Yolken RH, Bahn S, Carruthers VB
Schizophr Bull
Identification of novel noninvasive markers for diagnosing nonalcoholic steatohepatitis and related fibrosis by data mining (2015) Yoshimura K, Okanoue T, Ebise H, Iwasaki T, Mizuno M, Shima T, Ichihara J, Yamazaki K
Hepatology.
Lipoprotein-associated phospholipase A2, homocysteine, and Alzheimer’s disease (2015) Doody RS, Demirovic J, Ballantyne CM, Chan W, Barber R, Powell S, Pavlik V
Alzheimers Dement (Amst)
Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immune monitoring data (2015) Parkitny L, Middleton S, Baker K, Younger J
BMC Immunology
A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression (2015) Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ
J Immunol.
Responses to Bacteria, Virus and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia (2015) Valim C, Ahmad R, Lanaspa M, Tan Y, Acácio S, Gillette MA, Almendinger KD, Milner DA Jr, Madrid L, Pellé K, Harezlak J, Silterra J, Alonso PL, Carr SA, Mesirov JP, Wirth DF, Wiegand RC, Bassat Q
Am J Respir Crit Care Med.
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages (2015) Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC.
Nat Commun.
MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis (2015) Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ.
J Clin Invest
Markers of inflammation are associated with clinical outcomes in patients with metastatic renal cell carcinoma treated with nivolumab (2015) Sznol M, Fishman M, Escudier B, McDermott DF, Kluger H, Stadler WM, Perez-Gracia J, McNeel DG, Curti BD, Harrison MR, Plimack ER, Appleman L, Fong L, Drake CG, Young TC, Chasalow SD, Ross-MacDonald P, Simon JS, Walker D, Choueiri TK
J Immunother Cancer
Identification of circulatory biomarkers from clinical trial samples (2015) Brunet LR, Bodman-Smith K, Bodman-Smith M, Kassam Z, Dalgleish A, LaBrie S and Hagemann T
J Immunother Cancer
Plasma Biomarkers for Neuronal Ceroid Lipofuscinosis. (2015) Hersrud SL, Geraets RD, Weber KL, Chan CH, Pearce DA
FEBS J.
Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion. (2015) Poussin C, Laurent A, Peitsch MC, Hoeng J, De Leon H
Toxicol Sci.
MEDI-551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Sle1-Human CD19 Transgenic Mice. (2015) Gallagher S, Yusuf I, McCaughtry TM, Turman S, Sun H, Kolbeck R, Herbst R, Wang Y
Arthritis Rheumatol.
Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells (2015) Poussin C, Laurent A, Peitsch MC, Hoeng J, and De Leon H
Toxicology
Prognostic and predictive biomarkers of AAA growth rate. (2015) Deeg MA, Meijer CA, Chan LS, Shen L, Lindeman JH.
Curr Med Res Opin
Self-reactive IgE exacerbates interferon responses associated with autoimmunity (2015) Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA
Nat Immunol.
The Milieu Intérieur Study — an Integrative Approach for Study of Human Immunological Variance (2015) Thomas S, Rouilly V, Patin E, Alanio C, Dubois A, Delval C, Marquier L-G, Fauchoux N, Sayegrih S, Vray M, Duffy D, Quintana-Murci L, Albert ML, Abel L, Alcover A, Bousso P, Bruhns P, Cumano A, Daëron M, Delval C, Demangel C, Deriano L, Di Santo J, Dromer F, Eberl G, Enninga J, Freitas A, Gelpi O, Gomperts-Boneca I, Hercberg S, Lantz O, Leclerc C, Mouquet H, Pellegrini S, Pol S, Rogge L, Sakuntabhai A, Schwartz O, Schwikowski B, Shorte S, Soumelis V, Tangy F, Tartour E, Toubert A, Ungeheuer M-N, Quintana-Murci L, Albert ML
Clinical Immunology
Back To Top2014
Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation (2014) Blonder JP, Mutka SC, Sun X, Qiu J, Green LH, Mehra NK, Boyanapalli R, Suniga M, Look K, Delany C, Richards JP, Looker D, Scoggin C, Rosenthal GJ
BMC Pulm Med. 2014 Jan 10;14(1):3
Implementing lessons learned from previous bronchial biopsy trials in a new randomized controlled COPD biopsy trial with roflumilast (2014) Barnes NC, Saetta M, Rabe KF
BMC Pulm Med. 2014 Jan 31;14(1):9
Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS™) (2014) Xiang Y, Kogel U, Gebel S, Peck MJ, Peitsch MC, Akmaev VR, Hoeng J
Gene Regul Syst Bio. 2014 Feb 19;8:45-61
Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product (2014) Ruff KJ, DeVore DP
Modern Research in Inflammation, 3, 19-25
Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli (2014) Duffy D, Rouilly V, Libri V, Hasan M, Beitz B, David M, Urrutia A, Bisiaux A, LaBrie ST, Dubois A, Boneca IG, Delval C, Thomas S, Rogge L, Schmolz M, Quintana-Murci L, Albert ML
Immunity Volume 40, Issue 3, 20 March 2014, Pages 436–450
Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection (2014) Riva A, Laird M, Casrouge A, Ambrozaitis A, Williams R, Naoumov NV, Albert ML, Chokshi S
Hepatology. 2014 Mar 26
Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease (2014) Phillips RO, Sarfo FS, Landier J, Oldenburg R, Frimpong M, Wansbrough-Jones M, Abass K, Thompson W, Forson M, Fontanet A, Niang F, Demangel C
PLoS Negl Trop Dis. 2014 Apr 10;8(4):e2786
Nonclinical Safety Profile of BMS-986001, a Nucleoside Transcriptase Inhibitor for Combination Retroviral Therapy (2014) Mausumee G, Frank S, Shawn C, Dara H, Zhao Y, Soleil PM, Sanderson TP, Michael G, Marc D
Int J Toxicol. 2014 May 20;33(3):204-218
A prospective assessment of the effect of aminophylline therapy on urine output and inflammation in critically ill children (2014) Tamburro RF, Thomas NJ, Ceneviva GD, Dettorre MD, Brummel GL, Lucking SE
Front. Pediatr. 2:59
Altered microglial response to Aß plaques in APPPS1-21 mice heterozygous for TREM2 (2014) Ulrich JD, Finn MB, Wang Y, Shen A, Mahan TE, Jiang H, Stewart FR, Piccio L, Colonna M, Holtzman DM
Mol Neurodegener. 2014 Jun 3;9(1):20
Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT (2014) Pilat C, Frech T, Wagner A, Krüger K, Hillebrecht A, Pons-Kühnemann J, Scheibelhut C, Bödeker RH, Mooren FC
Scand J Med Sci Sports. 2014 Jun 12
Predicting therapeutic efficacy of intravenous immunoglobulin (IVIG) in individual patients with relapsing remitting multiple sclerosis (RRMS) by functional genomics (2014) Berger T, Jacob C, Haas J, Ransmayr G, Guger M, Zettl UK, Di Pauli F, Taumberger B, Wietek S, Meuer S, Reindl M, Giese T
Journal of Neuroimmunology DOI: 10.1016/j.jneuroim.2014.10.001
Citrus limonin glucoside supplementation decreased biomarkers of liver disease and inflammation in overweight human adults. (2014) Kelley DS, Adkins YC, Zunino SJ, Woodhouse LR, Bonnel EL, Breksa III AP, Manners GD, Mackey BE
Journal of Functional Foods
Elevated Carbon Monoxide to Carbon Dioxide Ratio in the Exhaled Breath of Mice Treated with a Single Dose of Lipopolysaccharide (2014) Langeroudi AG, Hirsch CM, Estabragh AS, Meinardi S, Blake DR, Barbour AG
Open Forum Infectious Diseases
Apolipoprotein H Expression Is Associated with Il28b Genotype and Viral Clearance in Hepatitis C Virus Infection (2014) Laird ME, Mohsen A, Duffy D, Mamdouh R, Lefouler L, Casrouge A, El-Daly M, Rafik M, Abdel-Hamid M, Soulier A, Pawlotsky J-M, Hézode C, Rosa I, Renard P, Mohamed MK, Bonnard P, Izopet J, Mallet V, Pol S, Albert ML, Fontanet A
Journal of Hepatology
Back To Top2013
Sweet Bing Cherries Lower Circulating Concentrations of Markers for Chronic Inflammatory Diseases in Healthy Humans (2013) Kelley DS, Adkins Y, Reddy A, Woodhouse LR, Mackey BE, Erickson KL
J Nutr. 2013 Jan 23. [Epub ahead of print]
The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes (2013) Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O
PLoS One. 2013;8(3):e58164
Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia (2013) Mishra BB, Li Q, Steichen AL, Binstock BJ, Metzger DW, Teale JM, Sharma J
PLoS One. 2013;8(3):e59616
The effects of vitamin A on cells of innate immunity in vitro (2013) Wojtal K, Wolfram L, Frey-Wagner I, Lang S, Scharl M, Vavricka SR, Rogler G
Toxicology in Vitro,
Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal Study (2013) Schilte C, Staikovsky F, Couderc T, Madec Y, Carpentier F, Kassab S, Albert ML, Lecuit M, Michault A
PLoS Negl Trop Dis. 2013 Mar;7(3):e2137
Application of meta-analysis methods for identifying proteomic expression level differences (2013) Amess B, Kluge W, Schwarz E, Haenisch F, Alsaif M, Yolken RH, Leweke FM, Guest PC, Bahn S.
Proteomics. 2013 Apr 14.
Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator (2013) Patel OV, Wilson WB, Qin Z
BioMetals, April 2013
CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients (2013) Ragab D, Laird M, Duffy D, Casrouge A, Mamdouh R, Abass A, Shenawy DE, Shebl AM, Elkashef WF, Zalata KR, Kamal M, Esmat G, Bonnard P, Fontanet A, Rafik M, Albert ML
Cytokine. 2013 May 7. pii: S1043-4666(13)00181-6
CD47 fusion protein targets CD172a+ cells in Crohn’s disease and dampens the production of IL-1ß and TNF (2013) Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M
J Exp Med. 2013 May 13. [Epub ahead of print]
Increased accumulation of regulatory granulocytic myeloid cells in mannose receptor C type 1-deficient mice correlates with protection in a mouse model of neurocysticercosis (2013) Mishra PK, Morris EG, Garcia JA, Cardona AE, Teale JM
Infect Immun. 2013 Apr;81(4):1052-63
Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin (2013) Mathes AL, Christmann RB, Stifano G, Affandi AJ, Radstake TR, Farina GA, Padilla C, McLaughlin S, Lafyatis R
Ann Rheum Dis. 2013 Jul 19
Systemic sRAGE is a Biomarker of Emphysema and Associated with AGER Genetic Variants in COPD Patients (2013) Cheng DT, Kim DK, Cockayne DA, Belousov A, Bitter H, Cho, MH, Duvoix A, Edwards LD, Lomas DA, Miller BE, Reynaert N, Tal-Singer R, Wouters E, Agusti A, Fabbri LM, Rames A, Visvanathan S, Rennard SI, Jones P, Parmar H, MacNee W, Wolff G, Silverman EK, Mayer RJ, Pillai SG, and on Behalf of the TESRA and ECLIPSE Investigators
American Journal of Respiratory And Critical Care Medicine ja (2013)
Modulation of cardiometabolic pathways in skin and serum from patients with psoriasis (2013) Mehta NN, Li K, Szapary P, Krueger J, Brodmerkel C
J Transl Med. 2013 Aug 22;11(1):194.
Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases (2013) Van Rompaey L, Galien R, van der Aar EM, Clement-Lacroix P, Nelles L, Smets B, Lepescheux L, Christophe T, Conrath K, Vandeghinste N, Vayssiere B, De Vos S, Fletcher S, Brys R, van 't Klooster G, Feyen JH, Menet C
J Immunol. 2013 Sep 4. [Epub ahead of print]
Interleukin 17F Level and Interferon Beta Response in Patients With Multiple Sclerosis (2013) Hartung HP, Steinman L, Goodin DS, Comi G, Cook S, Filippi M, O'Connor P, Jeffery DR, Kappos L, Axtell R, Knappertz V, Bogumil T, Schwenke S, Croze E, Sandbrink R, Pohl C
JAMA Neurol. 2013 Aug 1;70(8):1017-21
Suppression of Inflammation with Conditional Deletion of the Prostaglandin E2 EP2 Receptor in Macrophages and Brain Microglia (2013) Johansson JU, Pradhan S, Lokteva LA, Woodling NS, Ko N, Brown HD, Wang Q, Loh C, Cekanaviciute E, Buckwalter M, Manning-Bog AB, Andreasson KI
J Neurosci. 2013 Oct 2;33(40):16016-16032
The Innate Immune Response May Be Important For Surviving Plague In Wild Gunnison's Prairie Dogs (2013) Busch JD, Van Andel R, Stone NE, Cobble KR, Nottingham R, Lee J, VerSteeg M, Corcoran J, Cordova J, Van Pelt W, Shuey MM, Foster JT, Schupp JM, Beckstrom-Sternberg S, Beckstrom-Sternberg J, Keim P, Smith S, Rodriguez-Ramos J, Williamson JL, Rocke TE, Wagner DM
Journal of Wildlife Diseases 2013 49:4, 920-931
The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis (2013) Duffy D, Saleh R, Laird M, Soneson C, Fouler LL, El-Daly M, Casrouge A, Decalf J, Abbas A, Eldin NS, Fontes M, Hamid MA, Mohamed MK, Rafik M, Fontanet, Albert, M. L.
Hepatology
Identification of a molecular profile associated with immune status in first onset schizophrenia patients (2013) Herberth M, Rahmoune H, Schwarz E, Koethe D, Harris LW, Kranaster L, Witt SH, Spain M, Barnes A, Schmolz M, Leweke MF, Guest PC, Bahn S
Clin Schizophr Relat Psychoses
Development of a small animal peripheral challenge model of Japanese encephalitis virus using interferon deficient AG129 mice and the SA14-14-2 vaccine virus strain (2013) Calvert AE, Dixon KL, Delorey MJ, Blair CD, Roehrig JT
Vaccine. 2013 Nov 17. pii: S0264-410X(13)01533-8
Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory (2013) Liu B, Zupan B, Laird E, Klein S, Gleason G, Bozinoski M, Gal Toth J, Toth M
Nat Neurosci. 2013 Dec 1
Transient inflammatory-like state and microbial dysbiosis are pivotal in establishment of mucosal homeostasis during colonisation of germ-free mice (2013) Aidy SE, Derrien M, Aardema R, Hooiveld G, Richards SE, Dane A, Dekker J, Vreeken R, Levenez F, Doré J, Zoetendal EG, van Baarlen P, Kleerebezem M
Benef Microbes. 2013 Dec 9:1-11.
Seasonal H3N2 influenza A virus fails to enhance Staphylococcus aureus co-infection in a non-human primate respiratory tract infection model (2013) Kobayashi SD, Olsen RJ, Lacasse RA, Safronetz D, Ashraf M, Porter AR, Braughton KR, Feldmann F, Clifton DR, Kash JC, Bailey JR, Gardner DJ, Otto M, Brining DL, Kreiswirth BN, Taubenberger JK, Parnell MJ, Feldmann H, Musser JM, Deleo FR
Virulence. 2013 Oct 8;4(8). [Epub ahead of print]
Protective role of Mincle in bacterial pneumonia by regulation of neutrophil mediated phagocytosis and extracellular trap formation (2013) Sharma A, Steichen AL, Jondle CN, Mishra BB, Sharma J
J Infect Dis. 2013 Dec 17. [Epub ahead of print]
Suppression of soluble T cell-associated proteins by an anti-interferon-a monoclonal antibody in adult patients with dermatomyositis or polymyositis (2013) Guo X, Higgs BW, Rebelatto M, Zhu W, Greth W, Yao Y, Roskos LK, White WI
Rheumatology (Oxford). 2013 Dec 19
REG3-gamma-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum (2013) Loonen LM, Stolte EH, Jaklofsky MT, Meijerink M, Dekker J, van Baarlen P, Wells JM
Mucosal Immunol. 2013 Dec 18
Multi-analyte profile analysis of plasma immune proteins: altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection (2013) Huckans M, Fuller BE, Olavarria H, Sasaki AW, Chang M, Flora KD, Kolessar M, Kriz D, Anderson JR, Vandenbark AA, Loftis JM
Brain and Behavior
Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation (2013) Sauer UG, Vogel S, Aumann A, Hess A, Kolle SN, Ma-Hock L, Wohlleben W, Dammann M, Strauss V, Treumann S, Gröters S, Wiench K, van Ravenzwaay B, Landsiedel R
Toxicol Appl Pharmacol. 2013 Dec 29. pii: S0041-008X(13)00570-X
Distinct Roles For Hepcidin and Interleukin 6 In The Recovery From Anemia Following Administration Of Heat-Killed Brucella Abortus (2013) Gardenghi S, Renaud TM, Meloni A, Casu C, Crielaard BJ, Bystrom LM, Greenberg-Kushnir N, Sasu BJ, Cooke KS, Rivella S
Blood. 2013 Dec 19. [Epub ahead of print]
Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface car (2013) Ma-Hock L, Strauss V, Treumann S, Küttler K, Wohlleben W, Hofmann T, Gröters S, Wiench K, van Ravenzwaay B, Landsiedel R
Part Fibre Toxicol. 2013 Jun 17;10(1):23
C-Type Lectin Receptor Clec4d Plays a Protective Role in Resolution of Gram-Negative Pneumonia (2013) Steichen AL, Binstock BJ, Mishra BB, Sharma J
Journal of Leukocyte Biology
Mesenteric Ischemia-Reperfusion Injury up-Regulates Certain Cc, Cxc, and Xc Chemokines and Results in Multi-Organ Injury in a Time-Dependent Manner (2013) Jawa RS, Quist E, Boyer CW, Shostrom VK, Mercer DW
European Cytokine Network
Inflammatory Mediator Profiling Reveals Immune Properties of Chemotactic Gradients and Macrophage Mediator Production Inhibition During Thioglycollate Elicited Peritoneal Inflammation (2013) Lam D, Harris D, Qin Z
Mediators of Inflammation
Placebo-Controlled Randomized Clinical Trial on the Immunomodulating Activities of Low- and High-Dose Bromelain after Oral Administration – New Evidence on the Antiinflammatory Mode of Action of Bromelain (2013) Müller S, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P
Phytotherapy Research
Back To Top2012
Systemic immunoregulatory and proteogenomic effects of tacrolimus to sirolimus conversion in liver transplant recipients (2012) Levitsky J, Mathew JM, Abecassis M, Tambur A, Leventhal J, Chandrasekaran D, Herrera N, Al-Saden P, Gallon L, Abdul-Nabi A, Yang GY, Kurian SM, Salomon DR, Miller J
Hepatology. 2012 Jan 11. doi: 10.1002/hep.25579. [Epub ahead of print]
Bronchial and Bronchiolar Fibrosis in Rats Exposed to 2,3-Pentanedione Vapors: Implications for Bronchiolitis Obliterans in Humans (2012) Morgan DL, Jokinen MP, Price HC, Gwinn WM, Palmer SM, Flake GP
Toxicol Pathol. 2012 Jan 3. [Epub ahead of print]
Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis (2012) Liu WM, Dennis JL, Gravett AM, Chanthirakumar C, Kaminska E, Coulton G, Fowler DW, Bodman-Smith M, Dalgleish AG
Br J Cancer. 2012 Jan 31 [Epub ahead of print]
A small animal peripheral challenge model of yellow fever using interferon-receptor deficient mice and the 17D-204 vaccine strain (2012) Thibodeaux BA, Garbinoa NC, Lissb NM, Piper J, Blair CD, Roehrig JT
Vaccine
RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents (2012) Xu D, Kim Y, Postelnek J, Vu MD, Hu DQ, Liao C, Bradshaw M, Hsu J, Zhang J, Pashine A, Srinivasan D, Woods J, Levin A, O'Mahony A, Owens TD, Lou Y, Hill RJ, Narula S, Demartino J, Fine JS
J Pharmacol Exp Ther. 2012 Apr;341(1):90-103
Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia (2012) Pedroso FE, Spalding PB, Cheung MC, Yang R, Gutierrez JC, Bonetto A, Zhan R, Chan HL, Namias N, Koniaris LG, Zimmers TA
J Cachexia Sarcopenia Muscle. 2012 Mar 29
Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses (2012) Joubert MK, Hokom M, Eakin C, Zhou L, Deshpande M, Baker MP, Goletz TJ, Kerwin BA, Chirmule N, Narhi LO, Jawa V
J Biol Chem. 2012 Jul 20;287(30):25266-79
Systemic Biomarkers of Neutrophilic Inflammation, Tissue Injury and Repair in COPD Patients with Differing Levels of Disease Severity (2012) Cockayne DA, Cheng DT, Waschki B, Sridhar S, Ravindran P, Hilton H, Kourteva G, Bitter H, Pillai SG, Visvanathan S, Müller KC, Holz O, Magnussen H, Watz H, Fine JS
PLoS One. 2012;7(6):e38629
Proteins involved in extracellular matrix dynamics are associated with respiratory syncytial virus disease severity (2012) Schuurhof A, Bont L, Hodemaekers HM, de Klerk A, de Groot H, Hofland RW, van de Pol AC, Kimpen JL, Janssen R
Eur Respir J. 2012 Jun;39(6):1475-81
Immunomodulatory Effect of the Topical Ophthalmic Janus Kinase Inhibitor Tofacitinib (CP-690,550) in Patients with Dry Eye Disease (2012) Huang JF, Yafawi R, Zhang M, McDowell M, Rittenhouse KD, Sace F, Liew SH, Cooper SR, Pickering EH
Ophthalmology. 2012 Jul;119(7):e43-50
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival (2012) Walter S, Weinschenk T, Stenzl A, Zdrojowy R, Pluzanska A, Szczylik C, Staehler M, Brugger W, Dietrich PY, Mendrzyk R, Hilf N, Schoor O, Fritsche J, Mahr A, Maurer D, Vass V, Trautwein C, Lewandrowski P, Flohr C, Pohla H, Stanczak JJ, Bronte V, Mandruzzato S, Biedermann T, Pawelec G, Derhovanessian E, Yamagishi H, Miki T, Hongo F, Takaha N, Hirakawa K, Tanaka H, Stevanovic S, Frisch J, Mayer-Mokler A, Kirner A, Rammensee HG, Reinhardt C, Singh-Jasuja H
Nat Med. 2012 Jul 29. doi: 10.1038/nm.2883. [Epub ahead of print]
A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation (2012) Scalley-Kim ML, Hess BW, Kelly RL, Krostag AR, Lustig KH, Marken JS, Ovendale PJ, Posey AR, Smolak PJ, Taylor JD, Wood CL, Bienvenue DL, Probst P, Salmon RA, Allison DS, Foy TM, Raport CJ
PLoS One. 2012;7(8):e43332
Characterization of AQX-1125, a small molecule SHIP1 activator Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo (2012) Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Chernoff D, Macrury T, Szabo C
Br J Pharmacol. 2012 Nov 2
Aging Exacerbates Obesity-Induced Oxidative Stress and Inflammation in Perivascular Adipose Tissue in Mice: A Paracrine Mechanism Contributing to Vascular Redox Dysregulation and Inflammation (2012) Bailey-Downs LC, Tucsek Z, Toth P, Sosnowska D, Gautam T, Sonntag WE, Csiszar A, Ungvari Z
J Gerontol A Biol Sci Med Sci. 2012 Dec 3. [Epub ahead of print]
Type I interferon and pattern recognition receptor signaling following particulate matter inhalation (2012) Erdely A, Antonini JM, Salmen-Muniz R, Liston A, Hulderman T, Simeonova PP, Kashon ML, Li S, Gu JK, Stone S, Chen BT, Frazer DG, Zeidler-Erdely PC
Part Fibre Toxicol. 2012 Jul 9;9:25
Characterization of immunologically active drugs in a novel organotypic co-culture model of the human gut and whole blood (2012) Schmohl M, Schneiderhan-Marra N, Baur N, Hefner K, Blum M, Stein GM, Joos TO, Schmolz M
Int Immunopharmacol. 2012 Dec;14(4):722-8
Sublytic Concentrations of Staphylococcus Aureus Panton-Valentine Leukocidin Alter Human Pmn Gene Expression and Enhance Bactericidal Capacity (2012) Graves SF, Kobayashi SD, Braughton KR, Whitney AR, Sturdevant DE, Rasmussen DL, Kirpotina LN, Quinn MT, Deleo FR
Journal of Leukocyte Biology
Back To Top2011
Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival (2011) Herberth M, Koethe D, Levin Y, Schwarz E, Krzyszton ND, Schoeffmann S, Ruh H, Rahmoune H, Kranaster L, Schoenborn T, Leweke MF, Guest PC, Bahn S
Proteomics 11: 94-105.
Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV (2011) Casrouge A, Decalf J, Ahloulay M, Lababidi C, Mansour H, Vallet-Pichard A, Mallet V, Mottez E, Mapes J, Fontanet A, Pol S, Albert ML
J Clin Invest. 121: 308-317.
Modulation of Inflammatory and Lipoprotein Pathways in Skin and Serum from Patients with Psoriasis (2011) Faha NNM, Li K, Szapary PO, Krueger J, Brodmerkel C
J Am Coll Cardiol; 57: 576
Inflammatory profile and response to anti-TNF therapy in patients with chronic pulmonary sarcoidosis (2011) Loza MJ, Brodmerkel C, Du Bois RM, Judson MA, Costabel U, Drent M, Kavuru M, Flavin S, Lo KH, Barnathan ES, Baughman RP
Clin Vaccine Immunol. 2011 Apr 20. [Epub ahead of print]
Human plasma inflammatory response during 5 days of exercise training in the heat (2011) Hailes WS, Slivka D, Cuddy J, Ruby BC
Journal of Thermal Biology
Phagocytosis and digestion of pH-sensitive fluorescent dye (Eos-FP) transfected E. coli in whole blood assays from patients with severe sepsis and septic shock (2011) Schreiner L, Huber-Lang M, Weiss ME, Hohmann H, Schmolz M, Schneider EM
J Cell Commun Signal. 2011 Jun;5(2):135-44
Validation of the Tetracycline Regulatable Gene Expression System for the Study of the Pathogenesis of Infectious Disease (2011) Chaturvedi AK, Lazzell AL, Saville SP, Wormley Jr.FL, Monteagudo C, Lopez-Ribot JL
PLoS ONE 6(5): e20449
Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter (2011) Erdely A, Salmen-Muniz R, Liston A, Hulderman T, Zeidler-Erdely PC, Antonini JM, Simeonova PP
Toxicology
Increased Disease Severity of Parasite-Infected TLR2-/- Mice Is Correlated with Decreased Central Nervous System Inflammation and Reduced Numbers of Cells with Alternatively Activated Macrophage Phenotypes in a Murine Model of Neurocysticercosis (2011) Gundra UM, Mishra BB, Wong K, Teale JM
Infect Immun. 2011 Jul;79(7):2586-96
Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis (2011) Hartgring SA, Willis CR, Dean CE Jr, Broere F, van Eden W, Bijlsma JW, Lafeber FP, van Roon JA
Arthritis Rheum. Jul;63(7):1878-87
Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation (2011) Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, De Angelis MH, Hamelmann E, Stoeger T, Schulz H
Respir Res. Jul 15;12(1):94
Rapidly Progressive, Fatal, Inhalation Anthraxlike Infection in a Human: Case Report, Pathogen Genome Sequencing, Pathology, and Coordinated Response (2011) Wright AM, Beres SB, Consamus EN, Long SW, Flores AR, Barrios R, Richter GS, Oh SY, Garufi G, Maier H, Drews AL, Stockbauer KE, Cernoch P, Schneewind O, Olsen RJ, Musser JM
Arch Pathol Lab Med. 2011 Aug 9. [Epub ahead of print]
A role for IL-27 in limiting T regulatory cell populations (2011) Wojno ED, Hosken N, Stumhofer JS, O'Hara AC, Mauldin E, Fang Q, Turka LA, Levin SD, Hunter CA
J Immunol. 2011 Jul 1;187(1):266-73
Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease (2011) Zhang L, Rajan V, Lin E, Hu Z, Han HQ, Zhou X, Song Y, Min H, Wang X, Du J, Mitch WE
FASEB J. 2011 May;25(5):1653-63
Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis (2011) Weinger JG, Brosnan CF, Loudig O, Goldberg MF, Macian F, Arnett HA, Prieto AL, Tsiperson V, Shafit-Zagardo B
J Neuroinflammation. 2011 May 15;8:49
Discrimination of agonist and antagonist forms of CXCL10 in biologic samples (2011) Casrouge A, Bisiaux A, Stephen L, Schmolz M, Mapes J, Pfister C, Pol S, Mallet V, Albert ML
Clin Exp Immunol. 2012 Jan;167(1):137-48
Deletion of a Malaria Invasion Gene Reduces Death and Anemia, in Model Hosts (2011) Gómez ND, Safeukui I, Adelani AA, Tewari R, Reddy JK, Rao S, Holder A, Buffet P, Mohandas N, Haldar K
PLoS ONE 6(9): e25477
Molecular profiling and gene expression analysis in cutaneous sarcoidosis: The role of interleukin-12, interleukin-23, and the T-helper 17 pathway (2011) Judson MA, Marchell RM, Mascelli M, Piantone A, Barnathan ES, Petty KJ, Chen D, Fan H, Grund H, Ma K, Baribaud F, Brodmerkel C
J Am Acad Dermatol. 2011 Sep 15. [Epub ahead of print]
Inhibition of RPE cell sterile inflammatory responses and endotoxin-induced uveitis by a cell-impermeable HSP90 inhibitor (2011) Qin S, Ni M, Wang X, Maurier-Mahé F, Shurland DL, Rodrigues GA
Exp Eye Res. 2011 Oct 18. [Epub ahead of print]
Serum markers associated with clinical improvement in patients with ankylosing spondylitis treated with golimumab (2011) Wagner C, Visvanathan S, Braun J, van der Heijde D, Deodhar A, Hsu B, Mack M, Elashoff M, Inman RD
Ann Rheum Dis. 2011 Oct 28. [Epub ahead of print]
Pathogenesis and Host Response in Syrian Hamsters following Intranasal Infection with Andes Virus (2011) Safronetz D, Zivcec M, LaCasse R, Feldmann F, Rosenke R, Long D, Haddock E, Brining D, Gardner D, Feldmann H, Ebihara H
PLoS Pathog 7(12): e1002426
Cox-2 expression, PGE2 and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice (2011) Gravaghi C, La Perle KM, Ogrodwski P, Kang JX, Quimby F, Lipkin M, Lamprecht SA
J Nutr Biochem. 2011 Apr;22(4):360-5
Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB (2011) Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L
Brain. 2011 Sep;134(Pt 9):2722-35
Back To Top2010
Attenuated Response of Aged Mice to Respiratory Francisella novicida Is Characterized by Reduced Cell Death and Absence of Subsequent Hypercytokinemia (2010) Mares CA, Sharma J, Ojeda SS, Li Q, Campos JA, Morris EG, Coalson JJ, Teale JM
PLoS ONE 11: e14088.
Inflammatory and Hemostatic Response to Cardiopulmonary Bypass in Pediatric Population: Feasibility of Seriological Testing of Multiple Biomarkers (2010) Agirbasli M, Nguyen ML, Win K, Kunselman AR, Clark JB, Myers JL, Undar A
Artif Organs. 34: 987-95.
Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs) (2010) Upadhyay S, Ganguly K, Stoeger T, Semmler-Bhenke M, Takenaka S, Kreyling WG, Pitz M, Reitmeir P, Peters A, Eickelberg O, Wichmann HE, Schulz H
Part Fibre Toxicol. 7: 27.
Results of a phase I study in patients suffering from secondary-progressive multiple sclerosis demonstrating the safety of the amino acid copolymer PI-2301 and a possible induction of an anti-inflammatory cytokine response (2010) Kovalchin J, Krieger J, Genova M, Collins K, Augustyniak M, Masci A, Hittinger T, Kuca B, Edan G, Braudeau C, Rimbert M, Patel U, Mascioli E, Zanelli E
J Neuroimmunol. 225: 153-63.
IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis (2010) Blumberg H, Dinh H, Dean C Jr, Trueblood ES, Bailey K, Shows D, Bhagavathula N, Aslam MN, Varani J, Towne JE, Sims JE
J Immunol 185:4354-62.
Multiple sclerosis: Identification and clinical evaluation of novel CSF biomarkers (2010) Ottervald J, Franzén B, Nilsson K, Andersson LI, Khademi M, Eriksson B, Kjellström S, Marko-Varga G, Végvári A, Harris RA, Laurell T, Miliotis T, Matusevicius D, Salter H, Ferm M, Olsson T
J Proteomics73: 1117-32.
Limited Systemic Sclerosis Patients with Pulmonary Arterial Hypertension Show Biomarkers of Inflammation and Vascular Injury (2010) Pendergrass SA, Hayes E, Farina G, Lemaire R, Farber HW, Whitfield ML, Lafyatis R.
PLoS ONE 5: e12106.
Lower Respiratory Tract Infection in Cynomolgus Macaques (Macaca fascicularis) Infected with Group A Streptococcus (2010) Olsen RJ, Ashraf M, Gonulal VE, Ayeras AA, Cantu C, Shea PR, Carroll RK, Humbird T, Greaver JL, Swain JL, Chang E, Ragasa W, Jenkins L, Lally KP, Blasdel T, Cagle P, Musser JM
Microb Pathog 49: 336-47.
Evidence for Endotoxin Contamination in Plastic Na+-Heparin Blood Collection Tube Lots (2010) Newhall KJ, Diemer GS, Leshinsky N, Kerkof K, Chute HT, Russell CB, Rees W, Welcher AA, Patterson SD, Means GD
Clin Chem 56: 1483-91.
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality (2010) Marchlik E, Thakker P, Carlson T, Jiang Z, Ryan M, Marusic S, Goutagny N, Kuang W, Askew GR, Roberts V, Benoit S, Zhou T, Ling V, Pfeifer R, Stedman N, Fitzgerald KA, Lin LL, Hall JP
J Leukoc Biol. 88: 1171-80.
In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation (2010) Marballi K, Quinones MP, Jimenez F, Escamilla MA, Raventós H, Soto-Bernardini MC, Ahuja SS, Walss-Bass C
J Mol Med. 88: 1133-41.
Identification of distinct plasma biomarker signatures in patients with rapid and slow declining forms of COPD (2010) Devanarayan V, Scholand MB, Hoidal J, Leppert MF, Crackower MA, O'Neill GP, Gervais FG
COPD 7: 51-58.
Peripheral Blood Biomarkers Predict Disease Progression And Mortality In IPF (2010) Richards TJ, Lindell KO, Klesen M, Kaminski N, Zhang Y, Gibson KF
Am J Respir Crit Care Me 181: A1120.
A Dual-Platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass. (2010) Umstead TM, Lu CJ, Freeman WM, Myers JL, Clark JB, Thomas NJ, Chinchilli VM, Vrana KE, Undar A, Phelps DS
Pediatr Res 67: 641-9.
Hypercoagulability, platelet function, inflammation and coronary artery disease acuity: Results of the Thrombotic RIsk Progression (TRIP) Study. (2010) Tantry US, Bliden KP, Suarez TA, Kreutz RP, Dichiara J, Gurbel PA
Platelets 21: 360-7.
Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates. (2010) Olsen RJ, Kobayashi SD, Ayeras AA, Ashraf M, Graves SF, Ragasa W, Humbird T, Greaver JL, Cantu C, Swain JL, Jenkins L, Blasdel T, Cagle PT, Gardner DJ, DeLeo FR, Musser JM
Am J Pathol 176: 1346-1354.
Interleukin-15 enhances proliferation and chemokine secretion of human follicular dendritic cells. (2010) Gil M, Park SJ, Chung YS, Park CS
Immunology 130: 536-44.
Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza. (2010) Zavitz CC, Bauer CM, Gaschler GJ, Fraser KM, Strieter RM, Hogaboam CM, Stampfli MR
J Immunol 184: 2001-2013.
Comparative efficacy and safety of aliskiren and irbesartan in patients with hypertension and metabolic syndrome. (2010) Krone W, Hanefeld M, Meyer HF, Jung T, Bartlett M, Yeh CM, Rajman I, Prescott MF, Dole WP
J Hum Hypertens [Epub ahead of print]
Aged mice display an altered pulmonary host response to Francisella tularensis live vaccine strain (LVS) infections (2010) Mares CA, Ojeda SS, Li Q, Morris EG, Coalson JJ, Teale JM
Exp Gerontol. 45: 91-6.
Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study. (2010) van Erk MJ, Wopereis S, Rubingh C, van Vliet T, Verheij E, Cnubben NH, Pedersen TL, Newman JW, Smilde AK, van der Greef J, Hendriks HF, van Ommen B
BMC Med Genomics 3: 5.
The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes. (2010) Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schüller J, Xu H, Taguchi K, Yamamoto M, Müller T
Toxicol Sci 115: 238-252.
Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD (2010) Aaron SD, Vandemheen KL, Ramsay T, Zhang C, Avnur Z, Nikolcheva T, Quinn A
Respir Res. 2010 Apr 22;11:41
Synthetic Ligands Against TLR2-9 in TruCulture - whole blood assays distinguish clinical stages of SIRS (trauma) and sepsis (2010) Bindja J, Weiss ME, Schmolz M, Stein GM, Mapes J, Schneiderhan-Marra N, Joos TO, Schneider EM
TSIS Mar 9-13th
Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever (2010) Gowen BB, Julander JG, London NR, Wong MH, Larson D, Morrey JD, Li DY, Bray M
Virol J. 2010 Sep 16;7:240
Back To Top2009
Heterosubtypic anti-avian H5N1 influenza antibodies in intravenous immunoglobulins from globally separate populations protect against H5N1 infection in cell culture (2009) Sullivan JS, Selleck PW, Downton T, Boehm I, Axell AM, Ayob Y, Kapitza NM, Dyer W, Fitzgerald A, Walsh B, Lynch GW
J Mol Genet Med 3: 217-224.
Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice (2009) Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, Hamelmann E, Schulz H, Stoeger T
Part Fibre Toxicol. 6: 31.
Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile (2009) Gaschler GJ, Skrtic M, Zavitz CC, Lindahl M, Onnervik PO, Murphy TF, Sethi S, Stämpfli MR.
Am J Respir Crit Care Med. 179: 666-75.
Western-style diets induce oxidative stress and dysregulate immune responses in the colon in a mouse model of sporadic colon cancer (2009) Erdelyi I, Levenkova N, Lin EY, Pinto JT, Lipkin M, Quimby FW, Holt PR
J Nutr. 139: 2072-8.
Molecular Analyte Profiling of the Early Events and Tissue Conditioning Following Intravesical Bacillus Calmette-Guerin Therapy in Patients With Superficial Bladder Cancer. (2009) Bisiaux A, Thiounn N, Timsit MO, Eladaoui A, Chang HH, Mapes J, Mogenet A, Bresson JL, Prié D, Béchet S, Baron C, Sadorge C, Thomas S, Albert EB, Albert PS, Albert ML
J Urol 181: 1571-1580.
Strain-Dependent Increases in Retinal Inflammatory Proteins and Photoreceptor FGF-2 Expression in Streptozotocin-Induced Diabetic Rats. (2009) Kirwin SJ, Kanaly ST, Linke NA, Edelman JL
Invest Ophthalmol Vis Sci 50: 5396-5404.
RIP4 Regulates Epidermal Differentiation and Cutaneous Inflammation. (2009) Rountree RB, Willis CR, Dinh H, Blumberg H, Bailey K, Dean C Jr, Peschon JJ, Holland PM
J Invest Dermatol 130: 102-112.
Muscular Dystrophy Therapy by Nonautologous Mesenchymal Stem Cells: Muscle Regeneration Without Immunosuppression and Inflammation. (2009) Shabbir A, Zisa D, Leiker M, Johnston C, Lin H, Lee T
Transplantation 87: 1275-1282.
Vaccination with an Attenuated Strain of Francisella novicida Prevents T-Cell Depletion and Protects Mice Infected with the Wild-Type Strain from Severe Sepsis. (2009) Sharma J, Li Q, Mishra BB, Georges MJ, Teale JM
Infect Immun 77: 4314-4326.
Lethal Pulmonary Infection with Francisella Novicida is Associated with Severe Sepsis. (2009) Sharma J, Li Q, Mishra BB, Pena C, Teale JM
J Leukoc Biol 86: 491-504.
Regression of Human Pancreatic Tumor Xenografts in Mice After a Single Systemic Injection of Recombinant Vaccinia Virus GLV-1h68. (2009) Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA
Mol Cancer Ther 8: 141-151.
CCR5 Expression Levels Influence NFAT Translocation, IL-2 Production, and Subsequent Signaling Events during T Lymphocyte Activation. (2009) Camargo JF, Quinones MP, Mummidi S, Srinivas S, Gaitan AA, Begum K, Jimenez F, VanCompernolle S, Unutmaz D, Ahuja SS, Ahuja SK
J Immunol 182: 171-182.
RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke (2009) Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ Jr, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I
Am J Respir Cell Mol Biol 40: 147-158.
Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis (2009) Kirby PJ, Shines CJ, Taylor GJ, Bousquet RW, Price HC, Everitt JI, Morgan DL
Exp Lung Res. 2009 Dec;35(10):858-82
Back To Top2008
"Host Tissue Damage" Signal ATP Impairs IL-12 and IFNgamma Secretion in LPS Stimulated Whole Human Blood. (2008) Nalos M, Huang S, Sluyter R, Khan A, Santner-Nanan B, Nanan R, McLean AS
Intensive Care Med 34: 1891-1897.
Mechanisms of oncostatin M-induced pulmonary inflammation and fibrosis. (2008) Mozaffarian A, Brewer AW, Trueblood ES, Luzina IG, Todd NW, Atamas SP, Arnett HA
J Immunol 181: 7243-7253.
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. (2008) Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R
PLoS Biol 6: e123.
MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult. (2008) Thompson WL, Karpus WJ, Van Eldik LJ
J Neuroinflammation 5: 35.
Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response. (2008) Richardson MA, Gupta A, O'Brien LA, Berg DT, Gerlitz B, Syed S, Sharma GR, Cramer MS, Heuer JG, Galbreath EJ, Grinnell BW
J Pharmacol Exp Ther 325: 17-26.
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. (2008) Puthawala K, Hadjiangelis N, Jacoby SC, Bayongan E, Zhao Z, Yang Z, Devitt ML, Horan GS, Weinreb PH, Lukashev ME, Violette SM, Grant KS, Colarossi C, Formenti SC, Munger JS
Am J Respir Crit Care Med 177: 82-90.
Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis. (2008) Pulichino AM, Wang IM, Caron A, Mortimer J, Auger A, Boie Y, Elias JA, Kartono A, Xu L, Menetski J, Sayegh CE
Am J Respir Cell Mol Biol 39: 324-36.
Dexamethasone inhibits high glucose-, TNF-alpha-, and IL-1beta-induced secretion of inflammatory and angiogenic mediators from retinal microvascular pericytes. (2008) Nehmé A, Edelman J
Invest Ophthalmol Vis Sci 49: 2030-2038.
Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns. (2008) Mares CA, Ojeda SS, Morris EG, Li Q, Teale JM
Infect Immun 76: 3001-3010.
Two distinct activation states of plasmacytoid dendritic cells induced by influenza virus and CpG 1826 oligonucleotide. (2008) Iparraguirre A, Tobias JW, Hensley SE, Masek KS, Cavanagh LL, Rendl M, Hunter CA, Ertl HC, von Andrian UH, Weninger W
J Leukoc Biol 83: 610-620.
Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. (2008) Fabian E, Landsiedel R, Ma-Hock L, Wiench K, Wohlleben W, van Ravenzwaay B
Arch Toxicol 82: 151-157.
Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice. (2008) Cuaz-Pérolin C, Billiet L, Baugé E, Copin C, Scott-Algara D, Genze F, Büchele B, Syrovets T, Simmet T, Rouis M
Arterioscler Thromb Vasc Biol 28: 272-277.
alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung (2008) Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I.
Am J Respir Cell Mol Biol. 2008 Jun;38(6):689-98
Back To Top2007
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. (2007) Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I
Am J Physiol Lung Cell Mol Physiol 292: L567-L576.
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. (2007) Sakamori R, Takehara T, Ohnishi C, Tatsumi T, Ohkawa K, Takeda K, Akira S, Hayashi N
Hepatology 46: 1564-1573.
Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. (2007) Blumberg H, Dinh H, Trueblood ES, Pretorius J, Kugler D, Weng N, Kanaly ST, Towne JE, Willis CR, Kuechle MK, Sims JE, Peschon JJ
J Exp Med 204: 2603-2614.
Eotaxin-1/CC chemokine ligand 11: a novel eosinophil survival factor secreted by human pulmonary artery endothelial cells (2007) Farahi N, Cowburn AS, Upton PD, Deighton J, Sobolewski A, Gherardi E, Morrell NW, Chilvers ER
J Immunol. 2007 Jul 15;179(2):1264-73
Back To Top2006
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration. (2006) Schilling S, Goelz S, Linker R, Luehder F, Gold R
Clin Exp Immunol 145: 101-117.
Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection. (2006) Knorr CW, Allen SD, Torres AR, Smee DF
Antiviral Res 72: 125-133.
Characterization of the Inflammatory Response to a Highly Selective PDE4 Inhibitor in the Rat and the Identification of Biomarkers that Correlate with Toxicity. (2006) Dietsch GN, Dipalma CR, Eyre RJ, Pham TQ, Poole KM, Pefaur NB, Welch WD, Trueblood E, Kerns WD, Kanaly ST
Toxicol Pathol 34: 39-51.
Back To Top2005
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. (2005) Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A, Condliffe AM, Cowburn AS, Johnson N, Chilvers ER
J Exp Med 201: 105-115.
Multiplex proteomic approaches to sepsis research: case studies employing new technologies. (2005) Heuer JG, Cummins DJ, Edmonds BT
Expert Rev Proteomics 2: 669-680.
Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis. (2005) Heuer JG, Zhang T, Zhao J, Ding C, Cramer M, Justen KL, Vonderfecht SL, Na S
J Immunol 174: 7141-7146.
Back To Top2004
Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment. (2004) Motley ST, Morrow BJ, Liu X, Dodge IL, Vitiello A, Ward CK, Shaw KJ
Cell Microbiol 6: 849-865.
LXR-dependent gene expression is important for macrophage survival and the innate immune response. (2004) Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P
Cell 119: 299-309.
Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. (2004) Heuer JG, Sharma GR, Gerlitz B, Zhang T, Bailey DL, Ding C, Berg DT, Perkins D, Stephens EJ, Holmes KC, Grubbs RL, Fynboe KA, Chen YF, Grinnell B, Jakubowski JA
Crit Care Med 32: 1570-1578.
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