Idiopathic Pulmonary Fibrosis (IPF) Biomarkers

Using published data on potential prognostic markers, PROLIFIC (Prognostic Lung Fibrosis Consortium) has selected 11 promising blood-based protein biomarkers for accelerating drug development for new IPF therapies. The 11 biomarkers have utility in characterizing:

  • Epithelial damage (CA 125, CYFRA 21-1, SP-D, CA-19-9, KL-6),
  • Fibrosis (MMP-7, Tenascin C),
  • Inflammation (CCL18, CXCL13, slCAM1),
  • Thrombosis (PAI-1).

In collaboration with PROLIFIC, RBM has developed optimized and highly validated Luminex based sandwich immunoassays of the 11 biomarkers to support IPF clinical trials.

Multi-Analyte Profile (MAP) Platform

The RBM MAP platform has been built and optimized to help researchers discover and validate biomarker patterns for use in their drug and diagnostic development efforts. Robust multiplexing on the microsphere-based Luminex technology combined with automated liquid handling, delivers more data in less time than other platforms, resulting in comparable data to traditional ELISA assays.

  • High throughput multiplexing with automated liquid handling reduces sample volume requirements
  • Enhanced accuracy with use of multi-level controls, standard curves, and proprietary blockers
  • High quality and reproducibility with stringent quality control parameters for reliable data

We ensure quality for every multiplex, every analyte, every sample, every time.


About RBM

RBM is a CLIA certified biomarker testing laboratory with over 20 years of experience internally developing and manufacturing multiplex immunoassays validated to clinical laboratory standards.

The RBM platform appropriately combines Luminex and Simoa microsphere-based immunoassays with:

Other RBM Products

CustomMAP Builder

Our CustomMAP is a flexible option to let you pick specific biomarkers for your research needs. Customize the number of multiplexes to build your CustomMAP.

Speak to a sales representative to learn more about CustomMAP options.

50 sample minimum required. Volume requirements are dependent on the number of multiplexes selected.

Ultrasensitive Immunoassays - Simoa

Looking for trace quantities of markers? Ultrasensitive immunoassays achieve orders-of-magnitude greater sensitivity than conventional immunoassay platforms for when levels of key proteins are extremely low in serum or plasma.