Rules-Based Medicine

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Idiopathic Pulmonary Fibrosis (IPF) Biomarkers



Rules-Based Medicine offers 11 blood-based biomarkers to accelerate your development of new therapies for idiopathic pulmonary fibrosis (IPF). These biomarkers were chosen in collaboration with the Prognostic Lung Fibrosis Consortium (PROLIFIC) using published data on potential prognostic markers.


RBM offers optimized and highly validated Luminex-based sandwich immunoassays of these biomarkers to support your IPF trials. These markers have utility in characterizing:

  • Epithelial damage (CA 125, CYFRA 21-1, SP-D, CA-19-9, KL-6),
  • Fibrosis (MMP-7, Tenascin C),
  • Inflammation (CCL18, CXCL13, slCAM1),
  • Thrombosis (PAI-1).

In collaboration with PROLIFIC, RBM has developed optimized and highly validated Luminex based sandwich immunoassays of the 11 biomarkers to support IPF clinical trials.



ICAM-1 CA-125 BLC MMP-7 CA-19-9
KL-6 CYFRTA 21-1      

Multi-Analyte Profile (MAP) Platform

The RBM MAP platform has been built and optimized to help researchers discover and validate biomarker patterns for use in their drug and diagnostic development efforts. Robust multiplexing on the microsphere-based Luminex technology combined with automated liquid handling, delivers more data in less time than other platforms, resulting in comparable data to traditional ELISA assays.

  • High throughput multiplexing with automated liquid handling reduces sample volume requirements
  • Enhanced accuracy with use of multi-level controls, standard curves, and proprietary blockers
  • High quality and reproducibility with stringent quality control parameters for reliable data

We ensure quality for every multiplex, every analyte, every sample, every time.



About RBM

RBM is a CLIA certified biomarker testing laboratory with over 20 years of experience internally developing and manufacturing multiplex immunoassays validated to clinical laboratory standards.

The RBM platform appropriately combines Luminex and Simoa microsphere-based immunoassays with:

  • Precision and dependability of automated liquid handling systems
  • Advanced quality monitoring
  • Validated data reporting processes
  • Highly-trained and dedicated staff, including Project Managers

CustomMAP Builder

Our CustomMAP is a flexible option to let you pick specific biomarkers for your research needs. Customize the number of multiplexes to build your CustomMAP.

Speak to a sales representative to learn more about CustomMAP options.

50 sample minimum required. Volume requirements are dependent on the number of multiplexes selected.

Speak to a Sales Representative

Ultrasensitive Immunoassays - Simoa

Looking for trace quantities of markers? Ultrasensitive immunoassays achieve orders-of-magnitude greater sensitivity than conventional immunoassay platforms for when levels of key proteins are extremely low in serum or plasma.

Ultrasensitive Immunoassay Menu