CytokineMAP A

Myriad RBM HumanMAPs

Rules-Based Medicine’s CytokineMAP A is one of two core panels, along with CyokineMAP B, that provide quantitative measurement of key cytokines involved in inflammation, immune response, and repair.

Serum or plasma Other fluids*
70 µL 125 µL
*Cerebrospinal fluid, urine, tissue culture supernatants,  bronchoalveolar lavage, synovial fluid, tissue extracts, tears, skin washings, etc.




Antibody profiles in COVID-19 convalescent plasma prepared with amotosalen/UVA pathogen reduction treatment (2022) Bagri A, de Assis RR, Tsai CT, Simmons G, Mei ZW, Von Goetz M, Gatmaitan M, Stone M, Di Germanio C, Martinelli R, Darst O, Rioveros J, Robinson PV, Ward D, Ziman A, Settel D, Khan S, Busch MP, Felgner PL, Corash LM Transfusion
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Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll-like receptors 7 and 8 (2021) Port A, Shaw JV, Klopp-Schulze L, Bytyqi A, Vetter C, Husey E, Mammasse N, Ona V, Bachmann A, Strugala D, Reh C, Goteti K Pharmacology Researh and Perspective

Muscle damage in systemic sclerosis and CXCL10: The potential therapeutic role of PDE5 inhibition (2021) Corinalesi C, Ross RL, Abignano G, Antinozzi C, Marampon F, di Luigi L, Buch MH, Riccieri V, Lenzi A, Crescioli C, Del Galdo F International Journal of Molecular Sciences
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Serum biomarkers that predict lean mass loss over bed rest in older adults: An exploratory study (2020) Gawel SH, Davis GJ, Luo M, Deutz NEP, Wolfe RR, Pereira SL Clinica Chimica Acta
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Investigating data-driven biological subtypes of sychiatric disorders using specification-curve analysis (2020) Beijers L, van Loo HM, Romeijn JW, Lamers F, Schoevers RA, Wardenaar KJ Psychological Medicine

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TGFb receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer (2019) Melisi D, Garcia-Carbonero R, Macarulla T, Pezet D, Deplangue G, Fuchs M, Trojan J, Kozloff M, Simionato F, Cleverly A, Smith C, Wang S, Man M, Driscoll KE, Estrem ST, Lahn MMF, Benhadji KA, Tabernero J Cancer Chemotherapy and Pharmacology
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External Validation of a Pre-Transplant Biomarker Model (REVERSE) Predictive of Renal Recovery after Liver Transplantation (2019) Levitsky J, Asrani SK, Abecassis M, Ruiz R, Jennings LW, Klintmalm G Hepatology

The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation. (2019) Leiter O, Bernas SN, Seidemann S, Overall RW, Horenburg C, Kowal S, Kempermann G, Walker TL Scientific Reports

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Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease (2018) Gu JM, Yuam S, Sim D, Abe K, Liu P, Rosenbruch M, Bringmann P, Kauser K Experimental Hematology 2018

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury (2018) Proudfood A, Bayliffe A, O'Kane C, Wright T, Serone A, Bareille P, Brown V, Hamid U, Chen Y, Wilson R, Cordy J, Morley P, de Wildt Ruud, Elborn S, Hind M, Chilvres E, Griffiths M, Summers C, McAuley D Thorax

Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One

Key Proteins Involed in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity (2018) Dittrich A, Grimm D, Sahana J, Bauer J, Kruger M, Infanger M, Magnusson N Cellular Physiology and Biochemistry 2018

S100A12 and S100A8/9 proteins are biomarkers of articular disease activity in Blau syndrome (2018) Wang L, Rose CD, Foley KP, Anton J, Bader-Meunier B, Brissaud P, Chedeville G, Cimaz R, Fernandez-Martin J, Guly C, Hachulla E, Harjacek M, Mackensen F, Merino R, Modesto C, Hernandez A, Pajot C, Ramanan A, Thatayatikom A, Thomee C, Vastert S, Votta B, Bertin J, Wouters CH Rheumatology

Toxoplasma gondii inactivates human plasmacytoid dendritic cells by functional mimicry of IL-10 (2018) Piotr L, Zhao Y, Singh S, Dai J, Yap GS, Fitzgerald-Bocarsly P The Journal of Immunology

CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype (2018) Candido J, Morton JP, Bailey P, Barry ST, Balkwill FR, Sansom OJ Cell Reports
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Evaluation of plasma biomarkers of inflammation in patients with maple syrup urine disease (2018) Scaini G, Tonon T, Moura de Souza CF, Schuck PF, Ferreira GC, Quevedo J, Seda Neto J, Amorim T, Camelo Jr JS, Vitoria Barban Margutti A, Hencke Tresbach R, Sperb-Ludwig F, Boy R, V. de Medeiros PF, Schwards IVD, Luiz Streck E Journal of Inherited Metabolic Disease

IL-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses (2018) van Mens LJJ, van de Sande MGH, Menegatti S, Chen S, Blijdorp ICP, de Jong HM, Fluri IA, Latuhihin TE, van Kuijk AWR, Rogge L, Yeremenko NG, Baeten DLP Arthritis Rheumatol

Networks of blood proteins in the neuroimmunology of schizophrenia (2018) Jeffries CD, Perkins DO, Fournier M, Do KQ, Cuenod M, Khadimallah I, Domenici E, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Tsuang M, Walker EF, Woods SW Transl Psychiatry

Synergistic Cytokine Effects as Apremilast Response Predictors in Patients With Psoriasis (2018) Garcet S, Nograles K, Correa da Rosa J, Schafer PH, Krueger JG Journal of Allergy and Clinical Immunology

Cellular toxicity of silicon carbide nanomaterials as a function of morphology (2018) Chen F, Li G, Zhao ER, Li J, Hableel G, Lemaster JE, Bai Y, Sen GL, Jokerst JV Biomaterials
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IL-23 secreted by myeloid cells drives castration-resistant prostate cancer (2018) Calcinottoa A, Spataro C, Zagato E, Di Mitri D, Gil V, Crespo M, De Bernardis G, Losa M, Mirenda M, Pasquini E, Rinaldi A, Sumanasuriya S, Lambros MB, Neeb A, Luciano R, Bravi CA, Nava-Rodriques D, Dolling D, Prayer-Galetti T, Ferreira A, Briganti A, Esposito A, Barry S, Yuan W, Sharp A, de Bono J, Alimonti A Nature
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Effects of an FcyRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies (2018) Stein MM, Hrusch CL, Sperling AI, Ober C Genes and Immunity

Association between Cytokines and Functional, Hemodynamic Parameters, and Clinical Outcomes in Pulmonary Arterial Hypertension (2018) Joshi AA, Davey RA, Rao Y, Shen K, Benza R, Raina A Pulmonary Circulation

Altered regulation of the T-cell system in patients with CRPS (2018) Heyn J, Azad SC, Luchting B Inflammation Research

Dose escalation results from a first-in-human, phase I study of glucocorticoid-induced TNF receptor-related protein agonist AMG 228 in patients with advanced solid tumors (2018) Tran B, Carvajal RD, Marabelle A, Patel SP, LoRusso PM, Rasmussen E, Juan G, Upreti VV, Beers C, Ngarmchamnanrith G, Schoffski P Journal for ImmunoTherapy of Cancer
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Medial Forebrain Bundle Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Importance of BDNF and Inflammatory Cytokines (2018) Dandekar MP, Saxena A, Scaini G, Shin JH, Migut A, Giridharan VV, Zhou Y, Barichello T, Soares JC, Quevedo J, Fenoy AJ Molecular Neurobiology

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients (2018) Naing A, Infante JR, Papadopoulos KP, Chan IH, Shen C, Ratti NP, Autio KA, Wong DJ, Patel MR, Ott PA, Falchook GS, Pant S, Hung A, Pekarek KL, Wu V, Adamow M, McCauley S, Mumm JB, Wong P, Van Vlasselaer P, Levegue J, Tannir NM, Oft M Cancer Cell

Serum IP-10 levels and increased DPPIV activity are linked to circulating CXCR3+ T cells in cholestatic HCV patients (2018) Rau M, Schmitt J, Berg T, Kremer AE, Stieger B, Spanaus K, Bengsch B, Romero MR, Marin JJ, Keitel V, Klinker H, Tony HP, Mullhaupt B, Geier A PLoS One
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RNA-antimicrobial peptide complexes fuel a TLR- and NETosis-mediated inflammatory cycle of neutrophil activation in psoriasis (2018) Herster F, Bittner Z, Dickhoefer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Loeffler MW, Hartl D, Freund L, Schaekel K, Heiser M, Ghoreschi K, Weber ANR bioRxiv

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Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CR-8 ISS space mission - The SPHEROIDS project. (2017) Pietsch J, Gass S2, Nebuloni S, Echegoyen D, Riwaldt S, Baake C, Bauer J, Corydon TJ, Egli M, Infanger M, Grimm D Biomaterials
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Soluble intercellular adhesion molecule-1: a potential biomarker for pain intensity in chronic pain patients. (2017) Luchting B, Hinske LC, Rachinger-Adam B, Celi LA, Kreth S, Azad SC Biomark Med

Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Ployunsaturated Fatty Acids in a Dose Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. (2017) Lefort N, LeBlanc R, Surette M Nutrients
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Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine. (2017) Warnke E, Pietsch J, Kopp S, Bauer J, Sahana J, Wehland M, Kr?ger M, Hemmersbach R, Infanger M, L?tzenberg R, Grimm D Cell Physiol Biochem.
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The role of anxious distress in immune dysregulation in patients with major depressive disorder. (2017) Gaspersz R, Lamers F, Wittenberg G, Beekman ATF, van Hemert AM, Schoevers RA, Penninx BWJH Transl Psychiatry

Inflammatory profile analysis reveals differences in cytokine expression between smokers, moist snuff users, and dual users compared to non-tobacco consumers. (2017) Sgambato JA, Jones BA, Caraway JW, Prasad GL Cytokine

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. (2017) Steggerda SM, Bennett MK, Chen J, Emberley E, Huang T, Janes JR, Li W, MacKinnon AL, Makkouk A, Marguier G, Murray PJ, Neou S, Pan A, Parlati F, Rodriguez MLM, Van de Velde LA, Wang T, Works M, Zhang J, Zhang W, Gross MI J Immunother Cancer

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study (2017) Maher TM, Oballa E, Simpson JK, Porte J, Habgood A, Fahy WA, Flynn A, Monlyneaux PL, Braybrooke R, Divyateja H, Parfrey H, Rassl D, Russell AM, Saini G, Renzoni EA, Duggan AM, Hubbard R, Wells AU, Lukey PT, Marshall RP, Jenkins RG Lancet Respir Med
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Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination (2016) Fourati S, Cristescu R, Loboda A, Talla A, Filali A, Railkar R, Schaeffer AK, Favre D, Gagnon D, Peretz Y, Wang IM, Beals CR, Casimiro DR, Carayannopoulos LN, S?kaly RP Nat Commun. 2016 Jan 8;7:10369

Dynamic Macrophage Polarization-Specific miRNA Patterns Reveal Increased Soluble VEGF Receptor 1 by miR-125a-5p Inhibition. (2016) Melton DW, Lei XF, Gelfond JAL, Shireman PK Physiological Genomics

Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke (2016) Oviedo A, Lebrun S, Kogel U, Ho J, Tan WT, Titz B, Leroy P, Vuillaume G, Bera M, Martin F, Rodrigo G, Esposito M, Dempsey R, Ivanov NV, Hoeng J, Peitsch MC, Vanscheeuwijck P. Regul Toxicol Pharmacol.
Therapy Indications

Exercise-induced cytokine changes in antigen stimulated whole-blood cultures compared to serum (2016) Pilat C, Kr?ger K, Frech T, Mooren FC J Immunol Methods.

Differential expression of P2X7 receptor and IL-1? in nociceptive and neuropathic pain. (2016) Luchting B, Heyn J, Woehrle T, Rachinger-Adam B, Kreth S, Hinske LC, Azad SC J Neuroinflammation

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Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model. (2015) Atkinson SM, Nansen A, Usher PA, Sondergaard BC, Mackay CR, Friedrichsen B, Chang CC, Tang R, Skov S, Haase C, Hornum L. Autoimmunity. 2015 Apr 27:1-11. [Epub ahead of print]

Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis: a population-based cohort study. (2015) Hoeven TA, Kavousi M, Ikram AM, van Meurs JB, Bindels PJ, Hofman A, Franco OH, Bierma-Zeinstra SM. Rheumatology (Oxford). 2015 May 6. pii: kev106. [Epub ahead of print]

Effect of cerium oxide nanoparticles on sepsis induced mortality and NF-?B signaling in cultured macrophages. (2015) Selvaraj V, Manne ND, Arvapalli R, Rice KM, Nandyala G, Fankenhanel E, Blough ER. Nanomedicine (Lond). 2015 Apr;10(8):1275-88. doi: 10.2217/nnm.14.205.

Suppression of T Cell Activation and Collagen Accumulation by an Anti-Type I Interferon Receptor Monoclonal Antibody in Adult Patients with Systemic Sclerosis. (2015) Guo X, Higgs BW, Bay-Jensen AC, Karsdal MA, Yao Y, Roskos LK, White WI. J Invest Dermatol. 2015 May 20. doi: 10.1038/jid.2015.188. [Epub ahead of print]

Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of TNF-a receptor 1 (2015) Cordy JC, Morley PJ, Wright TJ, Birchler MA, Lewis AP, Emmins R, Chen YZ, Powley WM, Bareille PJ, Wilson R, Tonkyn J, Bayliffe AI, Lazaar AL. Clin Exp Immunol.

Late Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337) (2015) Dietsch GN, Randall TD, Gottardo R, Northfelt DW, Ramanathan RK, Cohen PA, Manjarrez KL, Newkirk M, Bryan JK, Hershberg RM Clinical Cancer Research

A phase 2 randomized dose-ranging study of the JAK2-selective inhibitor fedratinib (SAR302503) in patients with myelofibrosis (2015) Pardanani A, Tefferi A, Jamieson C, Gabrail NY, Lebedinsky C, Gao G, Liu F, Xu C, Cao H and Talpaz M Blood Cancer Journal

THU0223 Serum Biomarkers Associated with Changes in Asdas and MRI Following Treatment of Ankylosing Spondylitis with Golimumab (2015) Inman RD, Baraliakos X, Hermann KG, Braun J, Deodhar A, van der Heijde DF, Xu S, Hsu B Ann Rheum Dis

Identification of plasma biomarker concentration changes resulting from the administration of the Vascular Disrupting Agent BNC105 across 3 clinical trials in mesothelioma, ovarian and renal cancer (2015) Kremmidiotis G, Leske A, Simpson J, Doolin E, Iglesias J AACR 2015

Biomarker results from a clinical trial of nivolumab in patients (pts) with metastatic renal cell carcinoma (mRCC) (CA209-009): Gene expression, serum profiling for immune markers, and multiplex tissue immunohistochemistry (IHC) (2015) Choueiri TK, Fishman MN, Escudier B, Stadler WM, Chasalow S, Ross-Macdonald P, Jure-Kunkel M, Sznol M, and Simon JS Cancer Res

Novel data-mining approach identifies biomarkers for diagnosis of Kawasaki disease (2015) Tremoulet AH, Dutkowski J, Sato Y, Kanegaye JT, Ling XB, Burns JC Pediatr Res.

Common Effects on Cancer Cells Exerted by a Random Positioning Machine and a 2D Clinostat (2015) Svejgaard B, Wehland M, Ma X, Kopp S, Sahana J, Warnke E, Aleshcheva G, Hemmersbach R, Hauslage J, Grosse J, Bauer J, Corydon TJ, Islam T, Infanger M, Grimm D PLoS One

Multianalyte markers of schizophrenia and bipolar disorder: A preliminary study. (2015) Dickerson F, Schroeder J, Stallings C, Origoni A, Bahn S, Yolken R Schizophr Res.

PA401, a novel CXCL8-based biologic therapeutic with increased glycosaminoglycan binding, reduces bronchoalveolar lavage neutrophils and systemic inflammatory markers in a murine model of LPS-induced lung inflammation. (2015) Adage T, Del Bene F, Fiorentini F, Doornbos RP, Zankl C, Bartley MR, Kungl AJ Cytokine

A Phase 1 Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma (2015) Amaravadi RK, Schilder RJ, Martin LP, Levin M, Graham MA, Weng DE, Adjei AA Mol Cancer Ther.

Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice (2015) Mardare C, Kr?ger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC J Diabetes Res

Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia (2015) Tomasik J, Schultz TL, Kluge W, Yolken RH, Bahn S, Carruthers VB Schizophr Bull

Evidence for abnormal cytokine expression in Gulf War Illness: A preliminary analysis of daily immune monitoring data (2015) Parkitny L, Middleton S, Baker K, Younger J BMC Immunology

A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression (2015) Cho HS, Shin HM, Haberstock-Debic H, Xing Y, Owens TD, Funk JO, Hill RJ, Bradshaw JM, Berg LJ J Immunol.

Responses to Bacteria, Virus and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia (2015) Valim C, Ahmad R, Lanaspa M, Tan Y, Ac?cio S, Gillette MA, Almendinger KD, Milner DA Jr, Madrid L, Pell? K, Harezlak J, Silterra J, Alonso PL, Carr SA, Mesirov JP, Wirth DF, Wiegand RC, Bassat Q Am J Respir Crit Care Med.

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages (2015) Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC. Nat Commun.

MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis (2015) Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. J Clin Invest

Markers of inflammation are associated with clinical outcomes in patients with metastatic renal cell carcinoma treated with nivolumab (2015) Sznol M, Fishman M, Escudier B, McDermott DF, Kluger H, Stadler WM, Perez-Gracia J, McNeel DG, Curti BD, Harrison MR, Plimack ER, Appleman L, Fong L, Drake CG, Young TC, Chasalow SD, Ross-MacDonald P, Simon JS, Walker D, Choueiri TK J Immunother Cancer

Identification of circulatory biomarkers from clinical trial samples (2015) Brunet LR, Bodman-Smith K, Bodman-Smith M, Kassam Z, Dalgleish A, LaBrie S and Hagemann T J Immunother Cancer

Plasma Biomarkers for Neuronal Ceroid Lipofuscinosis. (2015) Hersrud SL, Geraets RD, Weber KL, Chan CH, Pearce DA FEBS J.

Systems Biology Reveals Cigarette Smoke-Induced Concentration-Dependent Direct and Indirect Mechanisms That Promote Monocyte-Endothelial Cell Adhesion. (2015) Poussin C, Laurent A, Peitsch MC, Hoeng J, De Leon H Toxicol Sci.

MEDI-551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Sle1-Human CD19 Transgenic Mice. (2015) Gallagher S, Yusuf I, McCaughtry TM, Turman S, Sun H, Kolbeck R, Herbst R, Wang Y Arthritis Rheumatol.

Systems toxicology-based assessment of the candidate modified risk tobacco product THS2.2 for the adhesion of monocytic cells to human coronary arterial endothelial cells (2015) Poussin C, Laurent A, Peitsch MC, Hoeng J, and De Leon H Toxicology

Prognostic and predictive biomarkers of AAA growth rate. (2015) Deeg MA, Meijer CA, Chan LS, Shen L, Lindeman JH. Curr Med Res Opin

Self-reactive IgE exacerbates interferon responses associated with autoimmunity (2015) Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA Nat Immunol.

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Implementing lessons learned from previous bronchial biopsy trials in a new randomized controlled COPD biopsy trial with roflumilast (2014) Barnes NC, Saetta M, Rabe KF BMC Pulm Med. 2014 Jan 31;14(1):9

Immunomodulatory Activities of a Concentrated Fruit and Vegetable Juice Tested in a Randomized, Placebo-Controlled, Double-Blind Clinical Trial in Healthy Volunteers (2014) Schmolz M, M?rz RW, Schaudt M, Schaudt C, Lauster C Food and Nutrition Sciences, Vol. 5 No. 4, 2014, pp. 341-350

Discovery of Emphysema Relevant Molecular Networks from an A/J Mouse Inhalation Study Using Reverse Engineering and Forward Simulation (REFS?) (2014) Xiang Y, Kogel U, Gebel S, Peck MJ, Peitsch MC, Akmaev VR, Hoeng J Gene Regul Syst Bio. 2014 Feb 19;8:45-61

Altered microglial response to A? plaques in APPPS1-21 mice heterozygous for TREM2 (2014) Ulrich JD, Finn MB, Wang Y, Shen A, Mahan TE, Jiang H, Stewart FR, Piccio L, Colonna M, Holtzman DM Mol Neurodegener. 2014 Jun 3;9(1):20

An integrated omics analysis: impact of microgravity on host response to lipopolysaccharide in vitro (2014) Chakraborty N, Gautam A, Muhie S, Miller SA, Jett M, Hammamieh R. BMC Genomics 2014 Aug 7;15(1):659. [Epub ahead of print]

Disrupted TH17/Treg Balance in Patients with Chronic Low Back Pain. (2014) Luchting B, Rachinger-Adam B, Zeitler J, Egenberger L, M?hnle P, Kreth S, Azad SC PLoS ONE 2014 Aug 14;9(8):e104883. doi: 10.1371/journal.pone.0104883
Therapy Indications

Cardiac mMCP-4+ mast cell expansion and elevation of IL-6, and CCR1/3 and CXCR2 signaling chemokines in an adjuvant-free mouse model of tree nut allergy. (2014) Gonipeta B, Para R, He Y, Srkalovic I, Ortiz T, Kim E, Parvataneni S, Gangur V. Immunobiology. 2014 Dec 2. pii: S0171-2985(14)00237-X. doi: 10.1016/j.imbio.2014.11.012. [Epub ahead of print]

Assessment of serum biomarkers in rats after exposure to pesticides of different chemical classes. (2014) Moser VC, Stewart N, Freeborn DL, Crooks J, MacMillan DK, Hedge JM, Wood CE, McMahen RL, Strynar MJ, Herr DW. Toxicol Appl Pharmacol. 2014 Dec 9;282(2):161-174. doi: 10.1016/j.taap.2014.11.016. [Epub ahead of print]

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Cytokines Associated with Increased Erythropoiesis in Sprague-Dawley Rats Administered a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin (2013) Andrews DA, Hamadeh HK, He YD, Boren BM, Turk JR, Boyce RW, Mytych DT, Barger TE, Salimi-Moosavi H, Sloey B, Elliott S, McElroy P, Sinclair AM, Shimamoto G, Pyrah IT, Lightfoot-Dunn RM Toxicol Pathol. 2013 May 14. [Epub ahead of print]

Autoantibodies to Variable Heavy (VH) Chain Ig Sequences in Humans Impact the Safety and Clinical Pharmacology of a VH Domain Antibody Antagonist of TNF-a Receptor 1 (2013) Holland MC, Wurthner JU, Morley PJ, Birchler MA, Lambert J, Albayaty M, Serone AP, Wilson R, Chen Y, Forrest RM, Cordy JC, Lipson DA, Bayliffe AI Journal of Clinical Immunology, July 2013
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Elevated Carbon Monoxide in the Exhaled Breath of Mice during a Systemic Bacterial Infection (2013) Barbour AG, Hirsch CM, Ghalyanchi Langeroudi A, Meinardi S, Lewis ER, Estabragh AS, Blake DR PLoS One. 2013 Jul 31;8(7):e69802
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Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory (2013) Liu B, Zupan B, Laird E, Klein S, Gleason G, Bozinoski M, Gal Toth J, Toth M Nat Neurosci. 2013 Dec 1

Applicability of rat precision-cut lung slices in evaluating nanomaterial cytotoxicity, apoptosis, oxidative stress, and inflammation (2013) Sauer UG, Vogel S, Aumann A, Hess A, Kolle SN, Ma-Hock L, Wohlleben W, Dammann M, Strauss V, Treumann S, Gr?ters S, Wiench K, van Ravenzwaay B, Landsiedel R Toxicol Appl Pharmacol. 2013 Dec 29. pii: S0041-008X(13)00570-X

Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface car (2013) Ma-Hock L, Strauss V, Treumann S, K?ttler K, Wohlleben W, Hofmann T, Gr?ters S, Wiench K, van Ravenzwaay B, Landsiedel R Part Fibre Toxicol. 2013 Jun 17;10(1):23

Mesenteric Ischemia-Reperfusion Injury up-Regulates Certain Cc, Cxc, and Xc Chemokines and Results in Multi-Organ Injury in a Time-Dependent Manner (2013) Jawa RS, Quist E, Boyer CW, Shostrom VK, Mercer DW European Cytokine Network

Placebo-Controlled Randomized Clinical Trial on the Immunomodulating Activities of Low- and High-Dose Bromelain after Oral Administration ? New Evidence on the Antiinflammatory Mode of Action of Bromelain (2013) M?ller S, M?rz R, Schmolz M, Drewelow B, Eschmann K, Meiser P Phytotherapy Research

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Intraindividual long term stability and response corridors of cytokines in healthy volunteers detected by a standardized whole-blood culture system for bed-side application (2012) Mueller SC, M?rz R, Schmolz M, Drewelow B BMC Med Res Methodol. 2012 Aug 1;12(1):112
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A role for IL-27 in limiting T regulatory cell populations (2011) Wojno ED, Hosken N, Stumhofer JS, O'Hara AC, Mauldin E, Fang Q, Turka LA, Levin SD, Hunter CA J Immunol. 2011 Jul 1;187(1):266-73

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Human cytokine response to Texas crotaline envenomation before and after antivenom administration. (2010) Crocker P, Zad O, Milling T, Maxson T, King B, Whorton E Am J Emerg Med. 28: 871-9.

Plasma biomarkers in carbon monoxide poisoning. (2010) Thom SR, Bhopale VM, Milovanova TM, Hardy KR, Logue CJ, Lambert DS, Troxel AB, Ballard K, Eisinger D Clin Toxicol (Phila) 48: 47-56.
Therapy Indications

Interleukin-15 enhances proliferation and chemokine secretion of human follicular dendritic cells. (2010) Gil M, Park SJ, Chung YS, Park CS Immunology 130: 536-44.

Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza. (2010) Zavitz CC, Bauer CM, Gaschler GJ, Fraser KM, Strieter RM, Hogaboam CM, Stampfli MR J Immunol 184: 2001-2013.

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Perturbation of mouse retinal vascular morphogenesis by anthrax lethal toxin (2009) Bromberg-White JL, Boguslawski E, Duesbery NS PLoS ONE 4: e6956.
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Growth Characteristics of the Nonhuman Primate Embryonic Stem Cell Line Cjes001 Depending on Feeder Cell Treatment. (2009) Fleischmann G, M?ller T, Blasczyk R, Sasaki E, Horn PA Cloning Stem Cells 11: 225-233.
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The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis - a mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide. (2009) Steger-Hartmann T, Raschke M, Riefke B, Pietsch H, Sieber MA, Walter J Exp Toxicol Pathol 61: 537-552.

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Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects. (2008) Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou-El-Ardat K, Ghardi M, Arlette M, Baatout S Dev Biol 322: 302-313.
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IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. (2008) Smithgall MD, Comeau MR, Yoon BR, Kaufman D, Armitage R, Smith DE Int Immunol 20: 1019-1030.
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The Protective Effect of the Blood Brain Barrier from Systemic Cytokines in an Animal Femur Fracture Model. (2007) Ott M, Davis AT, Vanderkolk W, Resau JH, Deheer DH, Jones CB, Stouffer C, Kubek EW J Trauma 63: 591-595.
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Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. (2007) Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, Ernst M, Saris CJ, O'Shea JJ, Hunter CA Nat Immunol 8: 1363-1371.
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Effects of the incubation in vitro with sorbents on serum proteomic pattern and cytokine concentration in cancer patients during chemotherapy--preliminary results. (2006) Piccolomini F, LouWratten M, Sereni L, Balestreri E, Donadio E, Felicioli A, Felicioli R, Donadio C Biomed Pharmacother 60: 463-467.
Therapy Indications

Murine embryonic stem cells secrete cytokines/growth modulators that enhance cell survival/anti-apoptosis and stimulate colony formation of murine hematopoietic progenitor cells. (2006) Guo Y, Graham-Evans B, Broxmeyer HE Stem Cells 24: 850-856.
Therapy Indications

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