Myriad RBM HumanMAPs

ImmunoMAP is a multiplexed immunoassay service product that quantitatively measures blood-based proteins involved in inflammation and immune responses. It includes more than 40 biomarker assays not currently found in Rules-Based Medicine’s InflammationMAP. The ImmunoMAP complements our existing set of assays for cytokines, chemokines, endothelial and tissue remodeling factors that regulate key functions of the immune system.

Use our CustomMAP Builder to combine select ImmunoMAP assays with other inflammation and immune response biomarker assays and service products such as InflammationMAP, CytokineMAP A and CytokineMAP B for a more comprehensive analysis of inflammation and immune-related biomarkers.

Click or mouse over biomarkers for more information. Analytes included in this MAP are subject to change.
1. 6Ckine2. AXL Receptor Tyrosine Kinase
3. Angiopoietin-24. B cell-activating factor1
5. CD 40 antigen6. CD40 Ligand
7. Chemokine CC-48. Dickkopf-related protein 1
9. E-Selectin110. Eotaxin-3
11. Epithelial-Derived Neutrophil-Activating Protein 7812. Erythropoietin
13. FASLG Receptor14. Granulocyte Colony-Stimulating Factor
15. Immunoglobulin E16. Interferon alpha
17. Interferon gamma Induced Protein 1018. Interferon-inducible T-cell alpha chemoattractant
19. Interleukin-1320. Interleukin-16
21. Interleukin-2222. Interleukin-6 receptor
23. Macrophage Inflammatory Protein-3 alpha24. Macrophage Migration Inhibitory Factor
25. Macrophage inflammatory protein 3 beta26. Macrophage-Derived Chemokine
27. Matrix Metalloproteinase-128. Matrix Metalloproteinase-7
29. Monocyte Chemotactic Protein 230. Monocyte Chemotactic Protein 4
31. Monokine Induced by Gamma Interferon32. Myeloid Progenitor Inhibitory Factor 1
33. Myeloperoxidase34. Stromal cell-derived factor-1
35. TNF-Related Apoptosis-Inducing Ligand Receptor 336. Thrombospondin-1
37. Thymus and activation-regulated chemokine38. Tumor necrosis factor ligand superfamily member 12
39. Tumor necrosis factor ligand superfamily member 13

1 This assay did not meet performance specifications in EDTA-Plasma and results should be used for information purposes only.

2 This assay did not meet performance specifications in Serum and results should be used for information purposes only.

Intended for Research Use Only.

Serum or plasma Other fluids*
160 µL 650 µL
*Cerebrospinal fluid, urine, tissue culture supernatants,  bronchoalveolar lavage, synovial fluid, tissue extracts, tears, skin washings, etc.


Autoimmune Disease and Arthritis


Target occupancy biomarker assay development using a conformation-selective antibody against small-molecule-bound TNF (2023) Elizabeth S Hickford, James O?Connell , Alison Maloney, Peter Florian, Geoffrey I Bioanalysis

Evaluation of BMS-986142, a reversible Bruton's tyrosine kinase inhibitor, for the treatment of rheumatoid arthritis: a phase 2, randomised, double-blind, dose-ranging -ranging, placebo controlled, adaptive design study (2023) Philip G Conaghan, Miroslawa Nowak, Shuyan Du, Yi Luo, Jessica Landis, Chahin Pachai, Aberra Fura, Ian M Catlett, Dennis M Grasela, Mikkel ?stergaard Rheumatoloty

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A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis (2021) Alexander Jr LC, McHorse G, Huebner JL, Bay-Jensen AC, Karsdal MA, Kraus VB Arthritis Research & Therapy

First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects (2021) Yang J, Lickliter JD, Hilson JL, Means GD, Sanderson RJ, Carley K, Tercero A, Manjarrez KL, Wiley JR, Peng SL Clinical and Translational Science

The Effect of a natural oral nutritional supplement on the level of intra-articular inflammatory mediators in patients with osteoarthritis of the knee (2021) Sharkey P, Shah Z, Gross M, Meade T, Davidoff S, Shohat N, Parvizi J Journal of Orthopaedic Experience and Innovation

Interferon genes are influenced by 17?-estradiol in SLE (2021) Singh RP, Hahn BH, Bischoff DS Frontiers in Immunology

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Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis. (2020) Herster F, Bittner Z, Archer NK, Dickhofer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Loffler MW, Kalbacher H, Vierbuchen T, Heine H, Miller LS, Hartl D, Freund L, Schakel K, Heister M, Ghoreschi K, Weber ANR Nature Communications

Fenebrutinib versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double-Blind, Phase II Trial (ANDES Study). (2020) Cohen S, Tuckwell K, Katsumoto TR, Zhao R, Galanter J, Lee C,, Rae J, Toth B, Ramamoorthi N, Hackney JA, Berman A, Damjanov N, Fedkov D, Jeka S, Chinn W, Townsend MJ, Morimoto AM, Genovese MC Arthritis& Rheumatology

Multiple Biomarker Approach for the Diagnosis and Therapy of Rheumatoid Arthritis (2020) Savvateeva E, Smoldovskaya O, Feyzkhanova G, Rubina A Critical Reviews in Clinical Laboratory Sciences

Systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome due to a CASP1 variant causing inflammasome hyperactivation (2020) Jorgensen SE, Christiansen M, Host C, Glerup M, Mahler B, Lausten MM, Gad HH, Hartmann R, Herlin T, Mogensen TH Rheumatology

Impact of carbohydrate-reduced nutrition in septic patients on ICU: study protocol for a prospective randomised controlled trial (2020) Rahmel T, Hubner M, Koos B, Wolf A, Willemsen KM, Straub G, Effinger D, Adamzik M, Kreth S BMJ Open

Safety and efficacy of neurostimulation with a miniaturised vagus nerve stimulation device in patients with multidrug-refractory rheumatoid arthritis: a two-stage multicentre, randomised pilot study (2020) Genovese MC, Gaylis NB, Sikes D, Kivitz A, Horowitz DL, Peterfy C, Glass EV, Levine YA, Chernoff D The Lancet Rheumatology

Molecular biomarkers of anti-TNF response in patients with rheumatoid arthritis (2020) Yoosuf N, Maciejewski M, Ziemek D, Jelinsky S, Folkersen, Muller M, Sahlstrom P, Vivar N, Catrina A, Berg L, Klareskog L, Padyukov L, Brynedal B Arthritis Research & Therapy

Modulation of cardiometabolic disease markers by type I interferon inhibition in systemic lupus erythematosus (2020) Casey KA, Smith MA, Sinibaldi D, Seto NL, Playford MP, Wang X, Carlucci PM, Wang L, Illei G, Yu B, Wang S, Remaley AT, Mehta NH, Kaplan MJ, White WI Arthritis Rheumatology

First-in-human, single- and multiple-ascending dose studies in healthy subjects to assess pharmacokinetics, pharmacodynamics, and safety/tolerability of iberdomide, a novel cereblon E3 ligase modulator (2020) Ye Y, Gaudy A, Schafer P, Thomas M, Weiss D, Chen N, Liu L, Xue Y, Carayannopoulos L, Palmisano M Clinical Pharmacology in Drug Development

Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial (2020) Aranow C, Atish-Fregoso Y, Lesser M, Mackay M, Anderson E, Chavan S, Zanos TP, Datta-Chaundhuri T, Bouton C, Tracey KJ, Diamond B Annals of the rheumatic diseases

Methamphetamine increases the proportion of SIV-infected microglia/macrophases, alters metabolic pathways, and elevates cell death pathways: a single-cell analysis (2020) Niu M, Morsey B, Lamberty BG, Emanuel K, Yu F, Leon-Rivera R, Berman JW, Gaskill PJ, Matt SM, Ciborowski PS, Fox HS Viruses

Efficacy and safety of abatacept in active primary Sj?gren's syndrome: results of a phase III, randomised, placebo-controlled trial (2020) Baer AN, Gottenberg JE, St Clair EW, Sumida T, Takeuchi T, Seror R, Foulks G, Nys M, Mukherjee S, Wong R, Ray N, Boothsma H Annals of the Rheumatic Disease

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo (2020) Menegatti S, Guillemot V, Latis E, Yahia-Cherbal H, Mittermuller D, Rouilly V, Mascia E, Rosine N, Koturan S, Millot G, Leloup C, Duffy D, Gleizes A, Hacein-Bey-Abina S, Milieu interieur Consortium, Sellam J, Berenbaum F, Miceli C, Dougados M, Bianchi E, Rogge L Ann Rheum Dis

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Exploring and redefining Autoimmune polyendocrine syndrome type 1 (2019) Bruserud Skipnes Kommunikasjon, University of Bergen

Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation. (2019) Haraden CA, Huebner JL, Hsueh MF, Li YJ, Kraus VB Arthritis Research & Therapy

SLE Plasma Profiling Identifies Unique Signatures of Lupus Nephritis and Discoid Lupus (2019) Smith MA, Henault J, Karnell JL, Parker ML, Riggs JM, Sinibaldi D, Taylor DK, Ettinger R, Grant EP, Sanjuan MA, Kolbeck R, Petri MA, Casey KA Scientific Reports

Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects (2019) Medvedeva IV, Stokes ME, Eisinger D, LaBrie ST, Ai J, Trotter MWB, Schafer P, Yang R Scientific Reports

Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study. (2019) Schafer PH, Kivitz AJ, Ma J, Korish S, Sutherland D, Li L, Azaryan A, Kosek J, Adams M, Capone L, Hur EM, Hough DR, Ringheim GE Rheumatology and Therapy

Autoinflammatory disease with corneal and mucosal dyskeratosis caused by a novel NLRP1 variant (2019) Herlin T, Jorgensen SE, Host C, Mitchell PS, Christensen MH, Lausten M, Larsen DA, Schmidt FI, Christiansen M, Mogensen TH Rheumatology

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Toxoplasma gondii inactivates human plasmacytoid dendritic cells by functional mimicry of IL-10 (2018) Piotr L, Zhao Y, Singh S, Dai J, Yap GS, Fitzgerald-Bocarsly P The Journal of Immunology

Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study (2018) Andersen M, Boesen M, Ellegaard K, Soderstrom K, Soe NH, Spee P, Morch UGW, Torp-Pedersen S, Bartels EM, Danneskiold-Samsoe B, Karlsson L, Bliddal H Plos One

IL-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses (2018) van Mens LJJ, van de Sande MGH, Menegatti S, Chen S, Blijdorp ICP, de Jong HM, Fluri IA, Latuhihin TE, van Kuijk AWR, Rogge L, Yeremenko NG, Baeten DLP Arthritis Rheumatol

Cereblon modulator iberdomide induces degradation of the transcription factor Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus (2018) Schafer PH, Ye Y, Wu L, Kosek J, Ringheim G, Yang Z, Liu L, Thomas M, Palmisano M, Chopra R Ann Rheum Dis

Effects of an FcyRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies (2018) Stein MM, Hrusch CL, Sperling AI, Ober C Genes and Immunity

Proteomics in Chronic Arthritis - Will We Finally Have Useful Biomarkers? (2018) Kessel C, McArdle A, Verweyen E, Weinhage T, Wittkowski H, Pennington SR, Foell D Current Rheumatology Reports

Type I interferon receptor blockade with anifrolumab corrects innate and adaptive immune perturbations of SLE (2018) Casey KA, Guo X, Smith MA, Wang S, Sinibaldi D, Sanjuan MA, Wang L, Illei GG, White WI Lupus Science and Medicine

RNA-antimicrobial peptide complexes fuel a TLR- and NETosis-mediated inflammatory cycle of neutrophil activation in psoriasis (2018) Herster F, Bittner Z, Dickhoefer S, Eisel D, Eigenbrod T, Knorpp T, Schneiderhan-Marra N, Loeffler MW, Hartl D, Freund L, Schaekel K, Heiser M, Ghoreschi K, Weber ANR bioRxiv

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A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis after Methotrexate Failure (2017) Hambardzumyan K, Saevarsdottir S, Forslind K, Petersson IF, Wallman JK, Ernestam S, Bolce RJ, van Vollenhoven RF Arthritis Rheumatol

A Multibiomarker Disease Activity Score for Rheumatoid Arthritis Predicts Radiographic Joint Damage in the BeSt Study (2017) Markusse IM, Dirven L, van den Broek M, Bijkerk C, Han K.H, Ronday H.K, Bolce R, Sasso E, Kerstens P, Lems WF, Huizinga T, and Allaart CF J Rheumatol.

Altered Expression of MicroRNAs in Rheumatoid Arthritis (2017) Tavasolian E, Abdollahi E, Rezaei R, Momtazi AA, Henrotin Y, Sahebkar A J. Cell. Biochem.

Proteomics to predict the response to tumour necrosis factor-a inhibitors in rheumatoid arthritis using a supervised cluster-analysis based protein score (2017) Cuppen BVJ, Fritsch-Stork RDE, Eekhout, W de Jager I, Marijnissen AC, Bijlsma JWJ, Custers M, Van Laar JM, Lafeber FPJG, Welsing PMJ & on behalf of all Society for Rheumatology Research Utrecht (SRU) investigators Scand J Rheumatol

Clinical Features of Psoriatic Arthritis: a Comprehensive Review of Unmet Clinical Needs. (2017) McArdle A, Pennington S, FitzGerald O Clin Rev Allergy Immunol.

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A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of treatment with sirukumab (CNTO 136) in patients with active lupus nephritis (2016) Rovin B, van Vollenhoven R, Aranow C, Wagner C, Gordon R, Zhuang Y, Belkowski S, Hsu B Arthritis & Rheumatology

Type I Ifns Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-Versus-Host Disease (2016) Delaney TA, Morehouse C, Brohawn PZ, Groves C, Colonna M, Yao, Y, Sanjuan M, Coyle AJ The Journal of Immunology

Sj?gren?s Syndrome Patients with Ectopic Germinal Centers Present with a Distinct Salivary Proteome (2016) Delaleu N, Mydel P, Brun JG, Jonsson MV, Alimonti A, Jonsson R Rheumatology

Vagus Nerve Stimulation Inhibits Cytokine Production and Attenuates Disease Severity in Rheumatoid Arthritis (2016) Koopman FA, Chavan SS, Miljko S, Grazio S, Sokolovic S, Schuurman PR, Mehta AD, Levine YA, Faltys M, Zitnik R, Tracey KJ, Tak PP PNAS

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children (2016) Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, Von Mutius E, Vercelli D, Ober C, Sperling AI New England Journal of Medicine

Serum biomarkers and changes in clinical/MRI evidence of golimumab-treated patients with ankylosing spondylitis: results of the randomized, placebo-controlled GO-RAISE study (2016) Inman RD, Baraliakos X, Hermann KA, Braun J, Deodhar A, Heijde D, Xu S, and Hsu B Arthritis Res Ther.

Association of the multi-biomarker disease activity score with joint destruction in patients with rheumatoid arthritis receiving tumor necrosis factor-alpha inhibitor treatment in clinical practice (2016) Hirata S, Li W, Kubo S, Fukuyo S, Mizuno Y, Hanami K, Sawamukai N, Yamaoka K, Saito K, Defranoux NA, Tanaka Y Mod Rheumatol

Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritis: results from the SWEFOT trial (2016) Hambardzumyan K, Bolce RJ, Saevarsdottir S, Forslind K, Wallman JK, Cruickshank SE, Sasso E, Chernoff D and Van Vollenhoven R RMD

Biomarkers in Rheumatoid Arthritis, what is new? (2016) Gavrila BI, Ciofu C, and Stoica V J Med Life

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The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results From a Phase 3, Randomized, Placebo-Controlled Trial (PALACE 1). (2015) Schafer P, Chen P, Fang L, Wang A, Chopra R. J Immunol Res 2015 Jan 10 [Epub ahead of print]

Detection of Rheumatoid Arthritis-Interstitial Lung Disease is Enhanced by Serum Biomarkers. (2015) Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC, Golzarri MF, Traslosheros A, Chu SG, Frits ML, Iannaccone CK, Koontz D, Fuhrman C, Weinblatt ME, El-Chemaly SY, Washko GR, Hunninghake GM, Choi AM, Dellaripa PF, Oddis CV, Shadick NA, Ascherman DP, Rosas IO. Am J Respir Crit Care Med. 2015 Mar 30. [Epub ahead of print]

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model. (2015) Atkinson SM, Nansen A, Usher PA, Sondergaard BC, Mackay CR, Friedrichsen B, Chang CC, Tang R, Skov S, Haase C, Hornum L. Autoimmunity. 2015 Apr 27:1-11. [Epub ahead of print]

Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis: a population-based cohort study. (2015) Hoeven TA, Kavousi M, Ikram AM, van Meurs JB, Bindels PJ, Hofman A, Franco OH, Bierma-Zeinstra SM. Rheumatology (Oxford). 2015 May 6. pii: kev106. [Epub ahead of print]

Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles. (2015) Selvaraj V, Nepal N1, Rogers S, Manne ND, Arvapalli R, Rice KM, Asano S, Fankhanel E, Ma JJ, Shokuhfar T, Maheshwari M, Blough ER. Biomaterials. 2015 May 8;59:160-171. doi: 10.1016/j.biomaterials.2015.04.025. [Epub ahead of print]

Immune cell profiling to guide therapeutic decisions in rheumatic diseases. (2015) Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S. Nat Rev Rheumatol. 2015 Jun 2. doi: 10.1038/nrrheum.2015.71. [Epub ahead of print]

Suppression of T Cell Activation and Collagen Accumulation by an Anti-Type I Interferon Receptor Monoclonal Antibody in Adult Patients with Systemic Sclerosis. (2015) Guo X, Higgs BW, Bay-Jensen AC, Karsdal MA, Yao Y, Roskos LK, White WI. J Invest Dermatol. 2015 May 20. doi: 10.1038/jid.2015.188. [Epub ahead of print]

Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of TNF-a receptor 1 (2015) Cordy JC, Morley PJ, Wright TJ, Birchler MA, Lewis AP, Emmins R, Chen YZ, Powley WM, Bareille PJ, Wilson R, Tonkyn J, Bayliffe AI, Lazaar AL. Clin Exp Immunol.

THU0223 Serum Biomarkers Associated with Changes in Asdas and MRI Following Treatment of Ankylosing Spondylitis with Golimumab (2015) Inman RD, Baraliakos X, Hermann KG, Braun J, Deodhar A, van der Heijde DF, Xu S, Hsu B Ann Rheum Dis

Self-reactive IgE exacerbates interferon responses associated with autoimmunity (2015) Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA Nat Immunol.

BAFF (B Cell Activating Factor) Transcript Level in Peripheral Blood of Patients with SLE Is Associated with Same-Day Disease Activity as Well as Global Activity over the Next Year (2015) Zollars E, Bienkowska J, Czerkowicz J, Allaire N, Ranger AM, Magder L, Petri M Lupus Science

Multibiomarker disease activity score and C-reactive protein in a cross-sectional observational study of patients with rheumatoid arthritis with and without concomitant fibromyalgia (2015) Lee YC, Hackett J, Frits M, Iannaccone C, Shadick N, Weinblatt M, Segurado O and Sasso E Rheumatology

Enhancement of Patient Recruitment in Rheumatoid Arthritis Clinical Trials Using a Multi-Biomarker Disease Activity Score as an Inclusion Criterion (2015) Van Vollenhoven R, Bolce R, Hambardzumyan K, Saevarsdottir S, Forslind K, Petersson I, Sasso E, Hwang C, Segurado O, and Geborek P Arthritis & Rheumatol

Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment (2015) Rech J, Hueber AJ, Finzel S, Englbrecht M, Haschka J, Manger B, Kleyer A, Reiser M, Cobra JF, Figueiredo C, Tony HP, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Lorenz H-M, Nuesslein H, Alten R, Henes J, Krueger K, Schett G Ann Rheum Dis.

Relationship of multi-biomarker disease activity score and other risk factors with radiographic progression in an observational study of patients with rheumatoid arthritis (2015) Li W, Sasso E, van der Helm-van Mil A and Huizinga T Rheumatology

Interpreting the multi-biomarker disease activity score in the context of tocilizumab treatment for patients with rheumatoid arthritis (2015) Reiss WG, Devenport JN, Low JM, Wu G, Sasso E Rheumatol Int

Outcomes and costs of incorporating a multibiomarker disease activity test in the management of patients with rheumatoid arthritis (2015) Michaud K, Strand V, Shadick NA, Degtiar I, Ford K, Michalopoulos SN and Hornberger J Rheumatology

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Rapid Onset Clinical and Mechanistic Effects of anti-C5aR Treatment in the Mouse Collagen Induced Arthritis Model (2014) Andersson C, Wenander CS, Usher PA, Hebsgaard JB, Sondergaard BC, R?n? B, Mackay C, Friedrichsen B, Chang C, Tang R, Hornum L Clin Exp Immunol. 2014 Mar 25

Synovial explant inflammatory mediator production corresponds to rheumatoid arthritis imaging hallmarks: a cross sectional study (2014) Andersen, M., Boesen, M., Ellegaard, K., Christensen, R., S?derstr?m, K., S?e, N., & Bliddal, H Arthritis Research & Therapy, 16(3), R107

High fidelity between saliva proteomics and the salivary glands' biological state defines biomarker-signatures for primary Sj?gren's syndrome. (2014) Delaleu N, Mydel P, Kwee I, Brun JG, Jonsson MV, Jonsson R. Arthritis Rheumatol. 2014 Dec 29. doi: 10.1002/art.39015. [Epub ahead of print]

Development, manufacturing and characterization of a highly purified, liquid immunoglobulin g preparation from human plasma. (2014) Laursen IA, Blou L, Sullivan JS, Bang P, Balstrup F, Houen G. Transfus Med Hemother. 2014 Jun;41(3):205-12. doi: 10.1159/000357982. Epub 2014 Apr 14.

A multi-biomarker disease activity score tracks clinical response consistently in patients with rheumatoid arthritis treated with different anti-tumor necrosis factor therapies: A retrospective observational study (2014) Hirata S, Li W, Defranoux N, Cavet G, Bolce R, Yamaoka K, Saito K & Tanaka Y Mod Rheumatol.

Pretreatment multi-biomarker disease activity score and radiographic progression in early RA: results from the SWEFOT trial (2014) Hambardzumyan K, Bolce R, Saevarsdottir S, Cruickshank S, Sasso E, Chernoff D, Forslind K, Petersson IF, Geborek P, van Vollenhoven RF Ann Rheum Dis.

Vectra DA for the objective measurement of disease activity in patients with rheumatoid arthritis. (2014) Segurado OG, Sasso EH. Clin Exp Rheumatol.

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Evaluation of Serum Biomarkers Associated with Radiographic Progression in Methotrexate-naive Rheumatoid Arthritis Patients Treated with Methotrexate or Golimumab (2013) Wagner C, Chen D, Fan H, Hsia EC, Mack M, Emery P, Fleischmann RM J Rheumatol. 2013 Mar 1. [Epub ahead of print]

CD47 fusion protein targets CD172a+ cells in Crohn?s disease and dampens the production of IL-1? and TNF (2013) Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Sch?kel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M J Exp Med. 2013 May 13. [Epub ahead of print]

IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis (2013) Wang J, Platt A, Upmanyu R, Germer S, Lei G, Rabe C, Benayed R, Kenwright A, Hemmings A, Martin M, Harari O BMJ Open. 2013 Aug 19;3(8):e003199

Suppression of soluble T cell-associated proteins by an anti-interferon-a monoclonal antibody in adult patients with dermatomyositis or polymyositis (2013) Guo X, Higgs BW, Rebelatto M, Zhu W, Greth W, Yao Y, Roskos LK, White WI Rheumatology (Oxford). 2013 Dec 19

Impact of Rheumatoid Arthritis Disease Activity Test on Clinical Practice (2013) Peabody JW, Strand V, Shimkhada R, Lee R, Chernoff D PLoS ONE

Development of a Multi-Biomarker Disease Activity Test for Rheumatoid Arthritis (2013) Centola M, Cavet G, Shen Y, Ramanujan S, Knowlton N, Swan KA, Turner M, Sutton C, Smith DR, Haney DJ, Chernoff D, Hesterberg LK, Carulli JP, Taylor PC, Shadick NA, Weinblatt ME, Curtis JR PLoS ONE

A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study (2013) Hirata S, Dirven L, Shen Y, Centola M, Cavet G, Lems WF, Tanaka Y, Huizinga WJ and Allaart CF Rheumatology

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RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents (2012) Xu D, Kim Y, Postelnek J, Vu MD, Hu DQ, Liao C, Bradshaw M, Hsu J, Zhang J, Pashine A, Srinivasan D, Woods J, Levin A, O'Mahony A, Owens TD, Lou Y, Hill RJ, Narula S, Demartino J, Fine JS J Pharmacol Exp Ther. 2012 Apr;341(1):90-103

Increased serum ?2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus (2012) Hermansen ML, Hummelsh?j L, Lundsgaard D, Hornum L, Keller P, Fleckner J, Fox B, Poulsen LK, Jacobsen S Lupus. 2012 May 10. [Epub ahead of print]

Interleukin-7 aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation (2012) Hartgring SA, Willis CR, Bijlsma JW, Lafeber FP, van Roon JA Arthritis Res Ther. 2012 Jun 7;14(3):R137

Expanding the Psoriasis Disease Profile: Interrogation of the Skin and Serum of Patients with Moderate-to-Severe Psoriasis (2012) Su?rez-Fari?as M, Li K, Fuentes-Duculan J, Hayden K, Brodmerkel C, Krueger JG J Invest Dermatol. 2012 Jul 5

Markers of inflammation and bone remodelling associated with improvement in clinical response measures in psoriatic arthritis patients treated with golimumab (2012) Wagner CL, Visvanathan S, Elashoff M, McInnes IB, Mease PJ, Krueger GG, Murphy FT, Papp K, Gomez-Reino JJ, Mack M, Beutler A, Gladman D, Kavanaugh A Ann Rheum Dis. 2012 Sep 12. [Epub ahead of print]

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis (2012) Burmester GR, Weinblatt ME, McInnes IB, Porter D, Barbarash O, Vatutin M, Szombati I, Esfandiari E, Sleeman MA, Kane CD, Cavet G, Wang B, Godwood A, Magrini F Ann Rheum Dis.

Validation of a Novel Multibiomarker Test to Assess Rheumatoid Arthritis Disease Activity (2012) Curtis Jr, van der Helm-van Mil ah, Knevel R, Huizinga TW, Haney DJ, Shen Y, Ramanujan S, Cavet G, Centola M, Hesterberg LK, Chernoff D, Ford K, Shadick N, Hamburger M, Fleischmann R, Keystone E, and Weinblatt ME Arthritis Care & Res.

Characterization of a multiplex, 12-biomarker test for rheumatoid arthritis (2012) Eastman P.S, Manning WC, Qureshi F, Haney D, Cavet G, Alexander C, Hesterberg LK Pharm Biomed Anal.

Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study (2012) Bakker MF, Cavet G, Jacobs J, Bijlsma J, Haney DJ, Shen Y, Hesterberg LK, Smith D, Centola M, van Roon J, Lafeber F, Welsing P Ann Rheum Dis.

Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis (2012) Zhao X, Qureshi F, Eastman P.S, Manning WC, Alexander C, Robinson WH, Hesterberg LK J Immunol Methods

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Modulation of Inflammatory and Lipoprotein Pathways in Skin and Serum from Patients with Psoriasis (2011) Faha NNM, Li K, Szapary PO, Krueger J, Brodmerkel C J Am Coll Cardiol; 57: 576

Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis (2011) Hartgring SA, Willis CR, Dean CE Jr, Broere F, van Eden W, Bijlsma JW, Lafeber FP, van Roon JA Arthritis Rheum. Jul;63(7):1878-87

Associations between body mass, radiographic joint damage, adipokines and risk factors for bone loss in rheumatoid arthritis (2011) Baker JF, George M, Baker DG, Toedter G, Von Feldt JM, Leonard MB Rheumatology (Oxford). 2011 Sep 2. [Epub ahead of print]

Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis (2011) Ohashi K, Sato A, Takada T, Arai T, Nei T, Kasahara Y, Motoi N, Hojo M, Urano S, Ishii H, Yokoba M, Eda R, Nakayama H, Nasuhara Y, Tsuchihashi Y, Kaneko C, Kanazawa H, Ebina M, Yamaguchi E, Kirchner J, Inoue Y, Nakata K, Tazawa R Respir Med. 2011 Nov 22. [Epub ahead of print]

Macrophage-Specific Chemokines Induced via Innate Immunity by Amino Acid Copolymers and Their Role in EAE (2011) Kovalchin J, Krieger J, Genova M, Kawamoto N, Augustyniak M, Collins K, Bloom T, Masci A, Hittinger T, Dufour I, Strominger JL, Zanelli E PLoS ONE 6(12): e26274

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Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study (2010) Visvanathan S, Rahman MU, Keystone E, Genovese M, Klareskog L, Hsia E, Mack M, Buchanan J, Elashoff M, Wagner C Arthritis Res Ther. 12:R211

Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis (2010) Woo JM, Lin Z, Navab M, Van Dyck C, Trejo-Lopez Y, Woo KM, Li H, Castellani LW, Wang X, Iikuni N, Rullo OJ, Wu H, La Cava A, Fogelman AM, Lusis AJ, Tsao BP Arthritis Res Ther 12: R93.

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Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma. (2008) Duan H, Fleming J, Pritchard DK, Amon LM, Xue J, Arnett HA, Chen G, Breen P, Buckner JH, Molitor JA, Elkon KB, Schwartz SM Arthritis Rheum 58: 1465-1474.

Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel disease. (2008) Torrence AE, Brabb T, Viney JL, Bielefeldt-Ohmann H, Treuting P, Seamons A, Drivdahl R, Zeng W, Maggio-Price L Inflamm Bowel Dis 14: 480-490.

Biomarker profiles in serum and saliva of experimental Sj?gren's syndrome: associations with specific autoimmune manifestations. (2008) Delaleu N, Immervoll H, Cornelius J, Jonsson R Arthritis Res Ther 10: R22.

Inhibition of experimental Sj?gren's syndrome through immunization with HSP60 and its peptide amino acids 437-460 (2008) Delaleu N, Madureira AC, Immervoll H, Jonsson R Arthritis Rheum. Aug;58(8):2318-28

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Cutting edge: interleukin 17 signals through a heteromeric receptor complex. (2006) Toy D, Kugler D, Wolfson M, Vanden Bos T, Gurgel J, Derry J, Tocker J, Peschon J J Immunol 177: 36-39.

Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration. (2006) Schilling S, Goelz S, Linker R, Luehder F, Gold R Clin Exp Immunol 145: 101-117.

TWEAK is a novel arthritogenic mediator. (2006) Perper SJ, Browning B, Burkly LC, Weng S, Gao C, Giza K, Su L, Tarilonte L, Crowell T, Rajman L, Runkel L, Scott M, Atkins GJ, Findlay DM, Zheng TS, Hess H J Immunol 177: 2610-2620.

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Prophylactic administration of abatacept prevents disease and bone destruction in a rat model of collagen-induced arthritis. (2005) Kliwinski C, Kukral D, Postelnek J, Krishnan B, Killar L, Lewin A, Nadler S, Townsend R J Autoimmun 25: 165-171.

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