Fibroblast growth factor 23 (FGF-23)
Like its other FGF family members, FGF-23 is involved in embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and is overproduced by some tumors. FGF-23 is produced by osteocytes and osteoblasts in response to high circulating phosphate levels or elevated parathyroid hormone. It promotes decreased renal resorption of phosphate by downregulating phosphate transporters and by suppressing vitamin D production. It also decreases the intestinal absorption of phosphate. In human chronic kidney disease, plasma FGF-23 levels increase during early stages of kidney malfunction. It may also play a role in insulin resistance.
Swiss-Prot Accession Number: Q9GZV9
PublicationsSerum kidney injury molecule 1 and B2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes (2018) Colombo M, Looker HC, Farran B, Hess S, Groop L, Palmer CNA, Brosnan MJ, Dalton RN, Wong M, Turner C, Ahlqvist E, Dunger D, Agakov F, Durrington P, Livingstone S, Betteridge J, McKeigue PM, Colhoun HM Diabetologia