Cartilage Oligomeric Matrix Protein (COMP)
Cartilage oligomeric matrix protein (COMP) is 110kDa glycoprotein and is a member of the thrombospondin family of extracellular proteins. COMP is a potent suppressor of apoptosis in chondrocytes. COMP is not only cartilage-derived but was found widely in other tissues, including synovium and tendon. COMP is upregulated in rheumatoid arthritis and osteoarthritis, hepatocellular carcinomas, chronic pancreatitis, and pancreatic carcinomas. COMP levels correlate with cartilage degradation and it is a potential prognostic marker in inflammatory joint diseases.
Swiss-Prot Accession Number: P49747
PublicationsTGFb receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer (2019) Melisi D, Garcia-Carbonero R, Macarulla T, Pezet D, Deplangue G, Fuchs M, Trojan J, Kozloff M, Simionato F, Cleverly A, Smith C, Wang S, Man M, Driscoll KE, Estrem ST, Lahn MMF, Benhadji KA, Tabernero J Cancer Chemotherapy and Pharmacology