Protein S100-A4 (S100-A4)

Protein S100-A4 is a calcium/phospholipid-binding protein found in platelets, which promotes membrane fusion and is involved in exocytosis. Extracellular S100-A4 is reported to induce MMP production, activate MMPs, promote neurite outgrowth and stimulate cardiomyocyte proliferation. It has both a high and a low affinity calcium binding site. S100-A4 may also bind p53, myosin heavy chain II, F-actin, and liprin beta 1. It has been reported to exist as a dimer and is elevated in metatasic cell lines.

Swiss-Prot Accession Number: P26447

Product Associations Product Associations

This analyte is not currently part of Myriad RBM's testing menu.

Therapy Indications
Myriad RBM Publications Publications
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One