Protein S100-A4

Protein S100-A4 (S100-A4)

Protein S100-A4 is a calcium/phospholipid-binding protein found in platelets, which promotes membrane fusion and is involved in exocytosis. Extracellular S100-A4 is reported to induce MMP production, activate MMPs, promote neurite outgrowth and stimulate cardiomyocyte proliferation. It has both a high and a low affinity calcium binding site. S100-A4 may also bind p53, myosin heavy chain II, F-actin, and liprin beta 1. It has been reported to exist as a dimer and is elevated in metatasic cell lines.

Swiss-Prot Accession Number: P26447

 

Product Associations

This analyte is not currently part of Myriad RBM's testing menu.

 

Publications

Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One