Urokinase-type plasminogen activator receptor (uPAR)

Urokinase-type plasminogen activator receptor (uPAR) is a GPI-linked single chain glycoprotein that binds both the zymogen single chain pro-uPA and the enzymatically active two chain, high molecular weight uPA. uPAR has been found to be localized in sections of solid tumors of various human cancers and it is overexpressed in extracts of invasive breast, colorectal- and ovarian cancer tissues.

Swiss-Prot Accession Number: Q03405

Therapy Indications
Myriad RBM Publications Publications
Investigating data-driven biological subtypes of sychiatric disorders using specification-curve analysis (2020) Beijers L, van Loo HM, Romeijn JW, Lamers F, Schoevers RA, Wardenaar KJ Psychological Medicine
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Serum Proteomic Profiling of Major Depressive Disorder (2015) Bot M, Chan MK, Jansen R, Lamers F, Vogelzangs N, Steiner J, Leweke FM, Rothermundt M, Cooper J, Bahn S, Penninx BWJH Translational Psychiatry