Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha)
Stromal cell-derived factor-1 (SDF-1; CXCL12) has two forms, SDF-1 alpha and SDF-1 beta. They are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the additional four amino acids present in the carboxy-terminus of SDF-1 beta. SDF-1 is a chemoattractant for T-lymphocytes and monocytes, but not neutrophils. SDF-1 is a ligand for the CXCR4 receptor that functions as a co-receptor for lymphocytetropic HIV-1 strains and plays a role in the inhibition of infection in HIV.
Swiss-Prot Accession Number: P48061-2
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia (2020) Narayanan P, Curtis BR, Shen L, Schneider E, Tami JA, Paz S, Burel SA, Tai LJ, Machemer T, Kwoh TJ, Xia S, Shattil SJ, Witztum JL, Engelhardt JA, Henry SP, Monia BP, Hughes SG Nucleic Acid Therapeutics