Collagen IV (Collagen IV)
Collagen IV is found primarily in the basal lamina and comprises six a-chains, a1(IV) through a6(IV). These a-chains then form three heterotrimers: a1a1a2, a3a4a5, and a5a5a6. When the collagen IV meshwork is assembled, it provides a scaffold for the assembly of other basement membrane components through interactions with laminin, entactin/nidogen and heparan sulfate proteoglycan. Collagen IV is a substrate for growth of epithelial, endothelial, muscle and nerve cells and plays a role in the regulation of cell growth, differentiation and adhesion, and tissue formation.
Swiss-Prot Accession Number: P02462, P08572, Q01955, P53420, P29400, Q14031
PublicationsIdentifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: Machine learning on proteomics from the DETECT cohort (2020) Bauer Y, de Bernard S, Hickey P, Ballard K, Cruz J, Cornelisse P, Chadha-Boreham H, Distler O, Rosenberg D, Doelberg M, Roux S, Nayler O, Lawrie A European Respiratory Journal
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports