Monocyte Chemotactic Protein 3 (MCP-3)
Monocyte Chemotactic Protein 3 (MCP-3; CCL7) is a member of the family of CC chemokines and is produced by tumor cell lines and macrophages. It has been implicated in immunity-associated tumor rejection and in a number of pathologies involving immune response. At low concentrations, MCP-3 inhibits infection by some HIV-1 strains and at higher concentrations, enhances viral replication. It also plays a role in autoimmunity and other inflammatory conditions. Increased levels are found in MS, asthma, chronic sinusitis, ulcerative colitis, and cirrhosis. It is a chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. MCP-3 binds to CCR1, CCR2, and CCR3.
Swiss-Prot Accession Number: P80098
Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells. (2007) Caers J, Deleu S, Belaid Z, De Raeve H, Van Valckenborgh E, De Bruyne E, Defresne MP, Van Riet I, Van Camp B, Vanderkerken K Leukemia 21: 1580-1584.