B Lymphocyte Chemoattractant (BLC)
B Lymphocyte Chemoattractant (BLC, CXCL13) is a chemokine that, through its interaction with the receptor CXCR5, is a chemoattractant for B lymphocytes. BLC controls the organization of B cells within follicles of lymphoid tissues. It is secreted by dendritic cells, and is expressed highly in the liver, spleen, lymph nodes, and gut of humans.
Swiss-Prot Accession Number: O43927
Product AssociationsThis analyte is not currently part of Myriad RBM's testing menu.
PublicationsEvaluation of BMS-986142, a reversible Bruton's tyrosine kinase inhibitor, for the treatment of rheumatoid arthritis: a phase 2, randomised, double-blind, dose-ranging -ranging, placebo controlled, adaptive design study (2023) Philip G Conaghan, Miroslawa Nowak, Shuyan Du, Yi Luo, Jessica Landis, Chahin Pachai, Aberra Fura, Ian M Catlett, Dennis M Grasela, Mikkel ?stergaard Rheumatoloty
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease (2021) Pierson SK, Shenoy S, Oromendia AB, Gorzewski AM, Pai RA, Nabel CS, Ruth JR, parente SAT, Arenas DJ, Guilfoyle M, Reddy MP, Weinblatt M, Shadick N, Bower M, Pria AD, Masaki Y, Katz L, Mezey J, Beineke P, Lee D, Tendler C, Kambayashi T, Fossa A, van Rhee F, Fajgenbaum DC Blood Advances
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Type I interferon receptor blockade with anifrolumab corrects innate and adaptive immune perturbations of SLE (2018) Casey KA, Guo X, Smith MA, Wang S, Sinibaldi D, Sanjuan MA, Wang L, Illei GG, White WI Lupus Science and Medicine
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits (2016) Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, Alzheimer?s Disease Neuroimaging Initiative (ADNI), Holtzman D, Morris JC, Bales K, Pickering EH, Lee J, Heitsch L, Kauwe J, Goate A, Piccio L, Cruchaga C Scientific Reports
Phase I Trial of the Pan-Pi3k Inhibitor Pilaralisib (Sar245408/Xl147) in Patients with Chronic Lymphocytic Leukemia (Cll) or Relapsed/Refractory Lymphoma (2015) Brown JR, Davids MS, Rodon J, Abrisqueta P, Kasar SN, Lager J, Jiang J, Egile C, Awan FT American Association for Cancer Research
Update on the Safety and Efficacy of the Pan Class I Pi3k Inhibitor Sar245408 (Xl147) in Chronic Lymphocytic Leukemia and Non-Hodgkin?s Lymphoma Patients (2013) Davids MS, Rodon J, Abrisqueta P, Egile C, Ruiz-Soto R, Awan F Blood
Distinct Molecular Phenotypes in Male and Female Schizophrenia Patients (2013) Ramsey JM, Schwarz E, Guest PC, Van Beveren NJM, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Bahn S PLoS ONE
Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease (2012) Doecke JD, Laws SM, Faux NG, Wilson W, Burnham SC, Lam CP, Mondal A, Bedo J, Bush AI, Brown B, De Ruyck K, Ellis KA, Fowler C, Gupta VB, Head R, Macaulay SL, Pertile K, Rowe CC, Rembach A, Rodrigues M, Rumble R, Szoeke C, Taddei K, Taddei T, Trounson B, Ames D, Masters CL, Martins RN; for the Alzheimer's Disease Neuroimaging Initiative and Australian Imaging Biomarker and Lifestyle Research Group Arch Neurol. 2012 Jul 16:1-8
Bone Marrow Derived Mesenchymal Stromal Cells are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth In Vitro and In Vivo (2011) Xu S, Menu E, De Becker A, Van Camp B, Vanderkerken K, Van Riet I Stem Cells. 2011 Nov 18. [Epub ahead of print]