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Myriad RBM’s TruCulture® and Gene Expression Profiling Characterizes Immune Responses in Landmark Study Led by Institut Pasteur

SALT LAKE CITY, Utah, September 7, 2016 – Myriad RBM, Inc., a wholly owned subsidiary of Myriad Genetics, Inc. (NASDAQ: MYGN) a global leader in personalized medicine, announced today that researchers from the Institut Pasteur have published new landmark research from the Milieu Interieur Project relating to the ability to perform standardized transcriptome profiling based upon a variety of immune stimuli in the August issue of Cell Reports. The study looked at the expression levels of different genes in 25 subjects following TruCulture incubation with twenty clinically relevant immune system stimulants. The research demonstrated that expression levels from as few as 44 of the 572 genes tested could segregate responses from the various stimuli and reveal variations in immune response.

“We are excited by the results of this study which demonstrated that a relatively small subset of gene expression targets could explain the variability in immune response to different immune stimuli seen among patients,” said Matthew Albert, co-coordinator of Milieu Interieur and director of the Immunobiology of Dendritic Cells Unit at the Institut Pasteur. “The ability of TruCulture to perform this analysis in an ex-vivo environment is truly unique making it an invaluable tool for assessing potential biomarkers relevant to immune response in patients.”

To perform the study, the researchers at the Institute Pasteur utilized Myriad RBM’s TruCulture technology which is a proprietary blood collection and culturing system that allows researchers to perform ex-vivo immune system analysis. Unlike the current laboratory-based methods, TruCulture is deployed at the site of collection and therefore avoids variability from shipping and complex processing as well as the expense of a cell culture facility and staff.

“We are increasingly excited around the prospects for TruCulture both for use in pharmaceutical research as well as for potential future diagnostic products,” said Ralph McDade, president of Myriad RBM. “We are actively pursuing several research collaborations to develop TruCulture as a novel diagnostic in cancer immunotherapy, autoimmune disorders, mental illness and vaccine response.”

This research builds upon earlier work at the Institut Pasteur that looked at the ability of TruCulture to accurately and reproducibly measure protein based cytokine responses in patient samples relative to different immune stimuli. The approaches and learnings from this study and previous studies will now be utilized in over 1,000 healthy donors with the Milieu Interieur cohort that will evaluate how different factors such as age, gender, environment, lifestyle, and genetics contribute to variable immune responses.

About Institut Pasteur and the Milieu Interieur Project

The Institut Pasteur, a private foundation with officially recognized charitable status set up by Louis Pasteur in 1887, is today an internationally renowned center for biomedical research with a network of 33 institutes worldwide. In the pursuit of its mission to prevent and fight against diseases in France and throughout the world, the Institut Pasteur operates in four main areas: scientific and medical research, public health and health monitoring, teaching, and business development and technology transfer.
The Milieu Interieur project is a population-based study supported by the French National Ministry of Research and coordinated by the Institut Pasteur, Paris. The goal of Milieu Interieur is to characterize the immune phenotypes of 1,000 healthy subjects in response to 32 complex immune stimulants. Responses to these stimuli in TruCulture are being assessed using advanced cellular, nucleic acid, proteomic and metabolic assay technologies. For more information visit:

About Myriad Genetics

Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics. Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs. Myriad is focused on three strategic imperatives: transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets. For more information on how Myriad is making a difference, please visit the Company’s website:

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