Investigators observed samples from 84 naturally influenza-infected individuals and found increased levels of cytokines MCP-3, IFNa2 and plasma IL-10 predicted progression to more severe flu symptoms. While increased levels of plasma IL-10, MCP-3 and IL-6 levels predicted hospitalization. The findings from this paper also explain why infants are at high risk for complications, and why the benefits from antiviral drug oseltamivir are short-lived. https://www.atsjournals.org/doi/abs/10.1164/rccm.201309-1616OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed&&&#%2EUwYwmmfnZ1P