Phospho-Tau181 Simoa

Phospho-Tau181 Simoa (pTau181 Simoa)

Tau is a neuronal microtubule associated protein found mostly on axons. Tau functions to stabilize microtubules and promote tubule polymerization. Tau contains multiple phosphorylation sites and can phosphorylated by a number of kinases, including GSK3, CDK5, and PKA. In its hyperphosphorylated state, pTau (181) - tau phosphorylated at amino acid 181- is the major component of paired helical filaments, the building block of neurofibrillary lesions in Alzheimer?s Disease. Hyperphosphorylation impairs tau?s ability to bind and stabilize microtubules leading to the degeneration of the affected neurons.

Swiss-Prot Accession Number: P10636

 

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This analyte is not currently part of Myriad RBM's testing menu.