Interleukin-1 receptor type 2 (IL-1RII)

IL1 receptor Type II is one of two distinct types of receptors that bind to IL-1. It is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL-1RII has a short cytoplasmic domain and does not transduce IL1 signals. Both the membrane form and the soluble for of IL-1RII may serve as a decoy for IL1 and block binding to IL-1RI.

Swiss-Prot Accession Number: P27930


Myriad RBM Publications Publications
Clinical and Prognostic Biomarker Value of Blood-Circulating Inflammatory Cytokines in Hepatocellular Carcinoma (2023) Shadi Chamseddine, Yehia I. Mohamed, Sunyoung S. Lee, James C. Yao, Clinical Translational Research
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo (2020) Menegatti S, Guillemot V, Latis E, Yahia-Cherbal H, Mittermuller D, Rouilly V, Mascia E, Rosine N, Koturan S, Millot G, Leloup C, Duffy D, Gleizes A, Hacein-Bey-Abina S, Milieu interieur Consortium, Sellam J, Berenbaum F, Miceli C, Dougados M, Bianchi E, Rogge L Ann Rheum Dis
Speak to a Scientist