Interleukin-1 receptor type 2 (IL-1RII)

IL1 receptor Type II is one of two distinct types of receptors that bind to IL-1. It is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL-1RII has a short cytoplasmic domain and does not transduce IL1 signals. Both the membrane form and the soluble for of IL-1RII may serve as a decoy for IL1 and block binding to IL-1RI.

Swiss-Prot Accession Number: P27930

Myriad RBM Publications Publications
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo (2020) Menegatti S, Guillemot V, Latis E, Yahia-Cherbal H, Mittermuller D, Rouilly V, Mascia E, Rosine N, Koturan S, Millot G, Leloup C, Duffy D, Gleizes A, Hacein-Bey-Abina S, Milieu interieur Consortium, Sellam J, Berenbaum F, Miceli C, Dougados M, Bianchi E, Rogge L Ann Rheum Dis