Antithrombin-III (AT-III)

ATIII is a member of the serpin superfamily of serine protease inhibitors. ATIII, produced in the liver, is the prinicipal plasma serpin of blood clotting proteases, and inhibits thrombin, Factor Xa, as well as several other enzymes of the coagulation system. A deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease. ATIII also influences the inflammatory process.

Swiss-Prot Accession Number: P01008