Thrombomodulin (TM)

Thrombomodulin (TM), also known as CD141, is an integral membrane protein expressed on the surface of endothelial cells. It functions as a cofactor in the thrombin-induced activation of protein C by forming a 1:1 complex with thrombin. This complex stimulates fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor (TAFI) into its active form. Increased serum levels of thrombomodulin have been associated with smoking, cardiac surgery, atherosclerosis, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis.

Swiss-Prot Accession Number: P07204


 
Therapy Indications
Autoimmune Disease and Arthritis
Cardiac and Vascular Markers/Disease
Diabetes, Lipid and Carbohydrate Metabolism
Neuroscience and Neurological Disease
 
Myriad RBM Publications Publications
Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia (2022) Suzette L. Pereira , Marni E. Shoemaker, Susan Gawel, Gerard J. Davis Menghua Luo, Vikkie A. Mustad and Joel T. Cramer Nutrients
Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes. (2020) Colombo M, McGurnaghan SJ, Blackbourn LAK, Dalton RN, Dunger D, Bell S, Petrie JR, Green F, MacRury S, McKnight JA, Chalmers J, Collier A, McKeigue PM, Colhoun HM, Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators Diabetologia
Biomarker panels associated with progression of renal disease in type 1 diabetes. (2019) Colombo M, Valo E, McGurnaghan SJ, Sandholm N, Blackbourn LAK, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM Diabetologia
Discovery and validation of a biomarker model (preserve) predictive of renal outcomes after liver transplantation (2019) Levitsky J, Asrani SK, Klintmalm G, Schiano T, Moss A, Chavin K, Miller C, Guo K, Zhao L, Jennings LW, Brown M, Armstrong B, Abecassis M Hepatology
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Complexity of Macrophage Migration Inhibitory Factor (MIF) and Other Angiogenic Biomarkers Profiling in Pulmonary Arterial Hypertension. (2017) Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee P, Fares W Pulm Circ.
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
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