Luteinizing Hormone

Luteinizing Hormone (LH)

Lutenizing Hormone (LH) is a glycoprotein containing two polypeptide units, alpha and beta. The alpha subunit is identical to that of FSH, TSH, and hCG. The beta subunit varies between the four and determines the biological function. The beta subunit of LH is 121 amino acids. LH is synthesized and secreted by gonadotropes in the anterior pituitary gland and is necessary for proper reproductive function. LH triggers ovulation in females and initiates the conversion of residual follicle into the corpus luteum producing progesterone and preparing endometrium for possible pregnancy. In males, LH stimulates the production of testosterone

Swiss-Prot Accession Number: P01229, P01215

 

Product Associations

This analyte is not currently part of Myriad RBM's testing menu.

 

Publications

Measurement of a Surrogate Biomarker for Arginine Vasopressin Secretion in Association with Physiometric and Molecular Biomarkers of Aging. (2020) Guest PC, Bernstein HB, Dobrowolny H, Borucki K, Westphal S, Steiner J Methods in Molecular Biology

Increased serum levels of leptin and insulin in both schizophrenia and major depressive disorder: A cross-disorder proteomics analysis (2019) Cakici N, Bot M, Lamers F, Janssen T, van der Haan L, Bahn S, Penninx BWJH, van Beveren NJM European Neuropsychopharmacology

Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One

Serum proteins mediate depression?s association with dementia (2017) Royall DR, Al-Rubaye S, Bishnoi R, Palmer RF Plos One

High false-positive rate of a putative biomarker test to aid in the diagnosis of schizophrenia (2016) Wehler CA, Preskorn, SH Journal of Clinical Psychiatry

Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports

Serum Proteomic Profiling of Major Depressive Disorder (2015) Bot M, Chan MK, Jansen R, Lamers F, Vogelzangs N, Steiner J, Leweke FM, Rothermundt M, Cooper J, Bahn S, Penninx BWJH Translational Psychiatry

Identification of Subgroups of Schizophrenia Patients with Changes in Either Immune or Growth Factor and Hormonal Pathways (2013) Schwarz E, Van Beveren NJM, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S Schizophrenia Bulletin

Inhibin B and luteinizing hormone levels in girls aged 6-11 years from NHANES III, 1988-1994 (2012) Sims EK, Addo OY, Gollenberg AL, Himes JH, Hediger ML, Lee PA Clin Endocrinol (Oxf). 2012 Mar 24

Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index (2012) Wang P, Holst C, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WK, Andersen MR, van Baak MA, Rasmussen LG, Martinez JA, Jebb SA, Pfeiffer AF, Kafatos A, Handjieva-Darlenska T, Hlavaty P, Saris WH, Mariman EC Br J Nutr. 2012 Jan;107(1):106-19

Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival (2011) Herberth M, Koethe D, Levin Y, Schwarz E, Krzyszton ND, Schoeffmann S, Ruh H, Rahmoune H, Kranaster L, Schoenborn T, Leweke MF, Guest PC, Bahn S Proteomics 11: 94-105.

Luteinizing hormone, Testosterone and Inhibin B Levels in the Peripubertal Period and Racial/ethnic Differences among Boys Aged 6-11 years: Analyses from NHANES III, 1988-1994 (2010) Lee PA, Gollenberg AL, Hediger ML, Himes JH, Zhang Z, Buck Louis GM Clin Endocrinol (Oxf). 2010 Sep 2

Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia (2010) Schwarz E, Izmailov R, Spain M, Barnes A, Mapes JP, Guest PC, Rahmoune H, Pietsch S, Leweke FM, Rothermundt M, Steiner J, Koethe D, Kranaster L, Ohrmann P, Suslow T, Levin Y, Bogerts B, (JM) van Beveren N, McAllister G, Weber N, Niebuhr D, Cowan D, Yolken RH, Bahn S Biomark Insights5: 39?47.

Identification of targeted analyte clusters for studies of schizophrenia. (2010) Cheng TM, Lu YE, Guest PC, Rahmoune H, Harris LW, Wang L, Ma D, Stelzhammer V, Umrania Y, Wayland MT, Li? P, Bahn S Mol Cell Proteomics 9: 510-522.

Sex-specific serum biomarker patterns in adults with Asperger's syndrome (2010) Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S Mol Psychiatry. 2010 Sep 28. [Epub ahead of print]