Fibroblast Growth Factor 4 (FGF-4)
Fibroblast Growth Factor 4 (FGF-4) belongs to the heparin-binding growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The gene for FGF-4 (also known as FGFK or K-FGF for Kaposi sarcoma-associated FGF) was initially discovered as a transforming gene. FGF-4 does not seem to be expressed in normal adult tissues. In vitro, FGF-4 is mitogenic for fibroblasts and endothelial cells. FGF-4 has been shown to be a potent angiogenesis promoter in vivo.
Swiss-Prot Accession Number: P08620
Product AssociationsThis analyte is not currently part of Myriad RBM's testing menu.
PublicationsMetabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for Yersinia pestis (2019) Gautam A, Muhie S, Cakraborty N, Hoke A, Donohue D, Miller SA, Hammamieh R, Jett M Metabolomics
Hypothesis: cerebrospinal fluid protein markers suggest a pathway toward symptomatic resilience to AD pathology (2019) Meyer PF, Savard M, Poirier J, Morgan D, Breitner J, for the Alzheimer's Disease Neuroimaging Initiative Alzheimer's & Dementia
Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria*American Journal of Nephrology (2016) Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB American Journal of Nephrology
A Semi-Mechanism Approach Based on Mri and Proteomics for Prediction of Conversion from Mild Cognitive Impairment to Alzheimer?s Disease (2016) Liu H, Zhou X, Jiang H, He H, Liu X Scientific Reports
Identification of Subgroups of Schizophrenia Patients with Changes in Either Immune or Growth Factor and Hormonal Pathways (2013) Schwarz E, Van Beveren NJM, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S Schizophrenia Bulletin