A recent study has identified the increased presence of neurofilament subunits (NFL) in the serum and cerebrospinal fluid of patients with multiple sclerosis (MS). The research, published in the Journal of Neuroimmunology, suggests that NFL may induce an immune response and represent and early marker of axonal damage. The results support many previous findings that the neurodegeneration observed in MS can be detected in the disease’s early stages using CSF or blood-based biomarkers such as NFL. What other markers might be indicative of pre- or early stage neurodegeneration?

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