Using multiplex biomarker analysis, researchers at Penn State University aim to define a panel of prognostic ALS markers.  This study shows the most meaningful results were obtained when combining biomarkers from CSF and plasma, rather than focusing on a single parameter. The combined plasma and CSF panel consists of six markers and accurately predicted the survival of 17 out of 18 participants. Although small, this study provides a compelling starting point for use of this multivariable modeling strategy in larger studies.