Many questions need to be answered in the process of designing a research study, even more so when biomarkers are going to be a component. While biomarkers can add a lot of information, e.g. insight into how subjects are responding to treatment or patient stratification, it is worth considering up front exactly what you need the biomarkers to do before diving in. An article in this week’s GEN magazine online discusses the importance of selecting assays to fit the application and addresses a number of important considerations that arise when choosing to use biomarkers; from deciding on the appropriate assay technology to understanding the impact of biomarker data in long-term studies.