Researchers from the University of Pittsburgh analyzed 242 proteins in conjunction with structural brain abnormalities to identify biological mechanisms that contribute to cognitive impairment in patients with LLD. A panel of proteins, consisting primarily of proteins involved in immune response, cell signaling and inflammation, were determined to help differentiate LLD patients with mild cognitive impairment from those with no cognitive impairment. The results are a promising start to figuring out what other factors are involved in the development of cognitive impairment and progression to dementia.