Rules-Based Medicine’s (RBM) internally developed and manufactured ultrasensitive immunoassay to interleukin-31 (IL-31) based on the Simoa® bead technology can accurately quantitate sub-pg/mL levels of IL-31 in human serum and plasma. Such sensitive IL-31 physiological detection and quantification provides diagnostic and therapeutic applications for allergic skin disorders, asthma, and inflammatory bowel disease.
Interleukin-31 is primarily made by activated Th2-type T cells, eosinophils, mast cells, macrophages, and dendritic cells. Its receptor, expressed primarily by monocytes, epithelial cells, and keratinocytes, is a heterodimer composed of the IL-31 receptor A (IL31RA) and oncostatin M receptor (OSMR) and signals through JAK1/2 and STAT1/3/5. IL-31 regulates cell homeostasis, cell proliferation, tissue remodeling, and production of pro-inflammatory cytokines. High expression of IL-31 is known to promote several allergic and autoimmune diseases. Patients with various autoimmune skin diseases such as atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, bullous pemphigoid, psoriasis, prurigo nodularis, and mastocytosis have increased serum IL-31. RBM’s ultrasensitive Simoa IL-31 assay can be a vital clinical research tool for investigating anti-IL-31 therapies.
Swiss-Prot Accession Number: Q6EBC2
Alternate names for this biomarker include:
(Serum and Plasma)
|Serum or plasma||Other fluids**|
|Interleukin-31 (IL-31)||0.024 pg/mL||0.006 pg/mL||100 µL||150 µL|
* Lower limit of quantitation (LLOQ) represents the lowest amount of an analyte that can be quantitatively determined with acceptable precision. LLOQ is determined by performing 2-fold serial dilutions of Standard to be tested in triplicate over three runs. The percent coefficient of variation (CV) is calculated for each of the dilution replicates, and the LLOQ is determined as the concentration at which the CV is 30%.
** Cerebrospinal fluid, urine, tissue culture supernatants, bronchoalveolar lavage, synovial fluid, tissue extracts, tears, skin washings, etc.
All assay services are performed in our CLIA-certified laboratory.
Intended for Research Use Only.