MetabolicMAP®

Myriad RBM HumanMAPs

A Multi-Analyte Profile (MAP) focused on the elucidation of metabolic biomarker patterns in a biological sample, such as serum or plasma. Rules-Based Medicine’s (RBM) MAP approach provides investigators with a reliable platform that can help discern these patterns in a cost-effective, efficient manner. RBM’s MetabolicMAP was designed by a major pharmaceutical company whose main interest was to glean insight into multiple metabolic pathways. This helps to expedite the go, no-go decisions made routinely in the drug development continuum.

Click or mouse over biomarkers for more information. Analytes included in this MAP are subject to change.
1. Adiponectin2. Angiotensin-Converting Enzyme
3. Follicle-Stimulating Hormone4. Glucagon-like Peptide 1, total
5. Insulin6. Leptin
7. Pancreatic Polypeptide8. Prolactin
9. Resistin

1 This assay did not meet performance specifications in EDTA-Plasma and results should be used for information purposes only.

2 This assay did not meet performance specifications in Serum and results should be used for information purposes only.

Intended for Research Use Only.

Serum or plasma Other fluids*
70 µL 300 µL
*Cerebrospinal fluid, urine, tissue culture supernatants,  bronchoalveolar lavage, synovial fluid, tissue extracts, tears, skin washings, etc.

Bibliography

Diabetes and Metabolic Markers

2023

Biomarkers Associated With Severe COVID-19 Among Populations With High Cardiometabolic Risk: A 2-Sample Mendelian Randomization Study (2023) Tushar Sood, Nicolas Perrot, Michael Chong, Pedrum Mohammadi-Shemirani, Maha Mushtaha, Darryl Leong, Sumathy Rangarajan, Sibylle Hess, Salim Yusuf, Hertzel C Gerstein, Guillaume Par?, Marie Pigeyre JAMA Network

Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP-1 (2023) Jennifer Leohr and Maria C. Kjellsson CPT: Pharmacometrics & Systems Pharmacology
 
Therapy Indications
 

Back To Top

2022

Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study (2022) Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong M, Musholt PB, Kurbasic A, De Masi F, Tsirigos K, Pedersen HK, Gudmundsdottir V, Thomas CE, Banasik K, Jennison C, Jones A, Kennedy G, Bell J, Thomas L, Frost G, Thomsen H, Allin K, Hansen TH, Vestergaard H, Hansen T, Rutters F, Elders P, t'Hart L, Bonnefond A, Canouil M, Brage S, Kokkola T, Heggie A, McEvoy D Cell Reports Medicine
 
Therapy Indications
 

Biomarker Changes in Response to a 12-Week Supplementation of an Oral Nutritional Supplement Enriched with Protein, Vitamin D and HMB in Malnourished Community Dwelling Older Adults with Sarcopenia (2022) Suzette L. Pereira , Marni E. Shoemaker, Susan Gawel, Gerard J. Davis Menghua Luo, Vikkie A. Mustad and Joel T. Cramer Nutrients
 
Therapy Indications
 

Live enteroviruses, but not other viruses, detected in human pancreas at the onset of type 1 diabetes in the DiViD study (2022) Lars Krogvold, Angelo Genoni, Anna Puggioni, Daniela Campani, Sarah J. Richardson, Christine S. Flaxman, Bj?rn Edwin, Trond Buanes, Knut Dahl-J?rgensen & Antonio Toniolo Diabetologia
 
Therapy Indications
 

Are U-shaped relationships between risk factors and outcomes artifactual? (2022) Reema Shah, Lehana Thabane, Hertzel C. Gerstein Journal of Diabetes
 
Therapy Indications
 

Back To Top

2021

NT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia ? A brief report from the ORIGIN trial (2021) Wijkman MO, Claggett BL, Pfeffer MA, Pare G, McQueen M, Hess S, Fu Lee S, Gerstein HC Journal of Diabetes and its Complications

High insulin in early childhood is associated with subsequent asthma risk independent of body mass index (2021) Carr TF, Granell R, Stern DA, Guerra S, Wright A, Halonen M, Henderson J, Martinex FD The Journal of Allergy and Clinical Immunology: In Practice
 
 

Validation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial (2021) Pigeyre M, Hess S, Gomez MF, Asplund O, Groop L, Pare G, Gerstein H Diabetologia
 
Therapy Indications
 

Back To Top

2020

Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes. (2020) Colombo M, McGurnaghan SJ, Blackbourn LAK, Dalton RN, Dunger D, Bell S, Petrie JR, Green F, MacRury S, McKnight JA, Chalmers J, Collier A, McKeigue PM, Colhoun HM, Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators Diabetologia
 
Therapy Indications
 

ACE and Type 2 Diabetes Risk: A Mendelian Randomization Study. (2020) Pigeyre M, Sjaarda J, Chong M, Hess S, Bosch J, Yusuf S, Gerstein H, Pare G Diabetes Care
 
Therapy Indications
 

Molecular Epidemiology of Inflammation Link with Type 2 Diabetes and Coronary Heart Disease (2020) Ligthart S Erasmus University Rotterdam

Innate Immune Stimulation of Whole Blood Reveals IFN-1 Hyper-Responsiveness in Type 1 Diabetes (2020) Rodrigues KB, Dufort MJ, Llibre A, Speake C, Jubayer Rahman M, Bondet V, Quiel J, Linsley PS, Greenbaum CJ, Duffy D, Tarbell KV Diabetologia

Predicting and elucidating the etiology of fatty liver disease: a machine learning modeling and validation study in the IMI DIRECT cohorts (2020) Atabaki-Pasdar N, Ohlsson M, Vinuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL, Koivula RW, Kurbasic A, Mutie PM, Fitipaldi H, Fernandez J, Dawed AY, Giordano GN, Forgie IM, McDonald TJ, Rutters F, Cederberg H, Chaanova E, Dale M, De Masi F, Thomas CE, Allin KH, Hansen TH, Heggie A, Hong MG, Elders PJM, Kennedy G, Kokkola T, Pedersen HK, Mahajan A, McEvoy D, Pattou F, Raverdy V, Haussler RS, Sharma S, Thomsen HS, Vangipurapu J, Vestergaard H, 't Hart LM, Adamski J, Musholt P, Brage S, Brunak S, Dermitzakis E, Frost G, Hansen T, Laakso M, pedersen O, Ridderstrale M, Ruetten H, Hattersley AT, Walker M, Beulens JWJ, Mari A, Schwenk JM, Gupta R, McCarthy MI, Pearson ER, Bell JD, Pavo I, Franks PW PLoS Medicine
 
Therapy Indications
 

Immune transriptome of cells infected with enterovirus strains obtained from cases of type 1 diabetes (2020) Poma AM, Genoni A, Broccolo F, Denaro M, Pugliese A, Basolo F, Toniolo A Microorganisms
 
Therapy Indications
 

Back To Top

2019

Amygdalar activity predicts future incident diabetes independently of adiposity (2019) Osborne MT, Ishai A, Hammad B, Tung B, Wang Y, Baruch A, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A Psychoneuroendocrinology
 
Therapy Indications
 

Performance of a clinical/proteomic panel to predict obstructive peripheral artery disease in patients with and without diabetes (2019) McCarthy CP, Shrestha S, Ibrahim N, van Kimmenade RRJ, Gaggin HK, Mukai R, Magaret C, Barnes G, Rhyne R, Garasic JM, Januzzi JL Open Heart

Biomarker panels associated with progression of renal disease in type 1 diabetes. (2019) Colombo M, Valo E, McGurnaghan SJ, Sandholm N, Blackbourn LAK, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM Diabetologia

Identification of Novel Causal Blood Biomarkers Linking Metabolically Favorable Adiposity With Type 2 Diabetes Risk (2019) Pigeyre M, Sjaarda J, Mao S, Chong M, Hess S, Yusuf S, Gerstein H, Pare G Diabetes Care
 
Therapy Indications
 

Novel Biomarkers for Change in Renal Function in People With Dysglycemia. (2019) Gerstein HC, Pare G, McQueen MJ, Lee SF, Bangdiwala SI, Kannt A, Hess A, ORIGIN Trial Investigators Diabetes Care

Back To Top

2018

Effects of canagliflozin versus glimepiride on adipokines and in inflammatory biomarkers in type 2 diabetes (2018) Garvey WT, Van Gaal L, Leiter LA, Vijapurkar U, List J, Cuddihy R, Ren J, Davies M Metabolism Clinical and Experimenta
 
Therapy Indications
 

Evaluation of plasma biomarkers of inflammation in patients with maple syrup urine disease (2018) Scaini G, Tonon T, Moura de Souza CF, Schuck PF, Ferreira GC, Quevedo J, Seda Neto J, Amorim T, Camelo Jr JS, Vitoria Barban Margutti A, Hencke Tresbach R, Sperb-Ludwig F, Boy R, V. de Medeiros PF, Schwards IVD, Luiz Streck E Journal of Inherited Metabolic Disease

The association of basal insulin treatment versus standard care with outcomes in anti-GAD positive and -negative subjects. A post-hoc analysis of the ORIGIN-trial (2018) Birkeland KI, Grill V, Wium C, McQueen MJ, Lopez-Jaramillo P, Lee SF, Gerstein HC Diabetes, Obesity and Metabolism
 
Therapy Indications
 

Serum kidney injury molecule 1 and B2-microglobulin perform as well as larger biomarker panels for prediction of rapid decline in renal function in type 2 diabetes (2018) Colombo M, Looker HC, Farran B, Hess S, Groop L, Palmer CNA, Brosnan MJ, Dalton RN, Wong M, Turner C, Ahlqvist E, Dunger D, Agakov F, Durrington P, Livingstone S, Betteridge J, McKeigue PM, Colhoun HM Diabetologia

Pegbelfermin (BMS-986036), PEGlyated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study (2018) Charles ED, Neuschwander-Tetri BA, Pablo Frias J, Kundu S, Luo Y, Tirucherai GS, Christrian R Obesity (Silver Spring)
 
Therapy Indications
 

Testosterone, sex hormone-binding globulin and risk of cardiovascular events: A report from the Outcome Reduction with an Initial Glargine Intervention trial (2018) Wang A, Arver S, Boman K, Gerstein HC, Fu Lee S, Hess S, Ryden L, Mellbin LG Preventive Cardiology
 
Therapy Indications
 

Back To Top

2017

The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility. (2017) van den Broek TJ, Kremer BH, Marcondes Rezende M, Hoevenaars FP, Weber P, Hoeller U, van Ommen B, Wopereis S Genes Nutr
 
Therapy Indications
 

Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study (2017) Brahimaj A, Ligthart S, Ghanbari M, Ikram MA, Hofman A, Franco OH, Kavousi M, Dehghan A Eur. J. Epidemiol.
 
Therapy Indications
 

Relation of antioxidant capacity of diet and markers of oxidative status with C-reactive protein and adipocytokines: a prospective study. (2017) Stringa N, Brahimaj A, Zaciragic A, Dehghan A, Ikram MA, Hofman A, Muka T, Kiefte-de Jong JC, Franco OH Metab.
 
Therapy Indications
 

Back To Top

2016

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits (2016) Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, Alzheimer?s Disease Neuroimaging Initiative (ADNI), Holtzman D, Morris JC, Bales K, Pickering EH, Lee J, Heitsch L, Kauwe J, Goate A, Piccio L, Cruchaga C Scientific Reports

Least absolute shrinkage and selection operator type methods for the identification of serum biomarkers of overweight and obesity: simulation and application. (2016) Vasquez MM, Hu C, Roe DJ, Chen Z, Halonen M, Guerra S BMC Med Res Methodol
 
Therapy Indications
 

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin (2016) Gerstein HC, Pare G, Hess S, Ford RJ, Sjaarda J, Raman K, McQueen M, Lee S, Haenel H, Steinberg GR; ORIGIN Investigators. Diabetes Care
 
Therapy Indications
 

Serum Levels of Apolipoproteins and Incident Type 2 Diabetes: A Prospective Cohort Study (2016) Brahimaj A, Ligthart S, Ikram MA, Hofman A, Franco OH, Sijbrands EJ, Kavousi M, Dehghan A Diabetes Care
 
Therapy Indications
 

Back To Top

2015

Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes. (2015) Looker HC, Colombo M, Agakov F, Zeller T, Groop L, Thorand B, Palmer CN, Hamsten A, de Faire U, Nogoceke E, Livingstone SJ, Salomaa V, Leander K, Barbarini N, Bellazzi R, van Zuydam N, McKeigue PM, Colhoun HM; on behalf of the SUMMIT Investigators. Diabetologia. 2015 Mar 5. [Epub ahead of print]

Novel first-dose adverse drug reactions during a phase I trial of olipudase alfa (recombinant human acid sphingomyelinase) in adults with Niemann-Pick disease type B (acid sphingomyelinase deficiency). (2015) McGovern MM, Wasserstein MP, Kirmse B, Duvall WL, Schiano T, Thurberg BL, Richards S, Cox GF. Genet Med. 2015 Apr 2. doi: 10.1038/gim.2015.24. [Epub ahead of print]
 
Therapy Indications
 

Biomarkers of rapid chronic kidney disease progression in type 2 diabetes (2015) Looker HC, Colombo M, Hess S, Brosnan MJ, Farran B, Dalton RN, Wong MC, Turner C, Palmer CNA, Nogceke E, Groop L, Salomaa V, Dunger DB, Agakov F, McKeigue PM, Colhoun HM Kidney International

Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice (2015) Mardare C, Kr?ger K, Liebisch G, Seimetz M, Couturier A, Ringseis R, Wilhelm J, Weissmann N, Eder K, Mooren FC J Diabetes Res

MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis (2015) Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ. J Clin Invest

Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer (2015) Pommier AJC, Farren M, Patel B, Wappett M, Michopoulos F, Smith NR, Kendrew J, Frith J, Huby R, Eberlein C, Campbell H, Womack C, Smith PD, Robertson J, Morgan S, Critchlow SE, Barry ST Cell Metabolism
 
 

Identifying Novel Biomarkers for Cardiovascular Events or Death in People with Dysglycemia (2015) Gerstein HC, Par? G, Mcqueen MJ, Haenel H, Lee SF, Pogue J, Maggioni AP, Yusuf S, Hess S Circulation
 
Therapy Indications
 

Back To Top

2014

The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins (2014) Yassine HN, Jackson AM, Borges CR, Billheimer D, Koh H, Smith D, Reaven P, Lau SS, Borchers CH Lipids Health Dis. 2014 Jan 8;13(1):8

Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome (2014) Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S Mol Autism. 2014 Jan 27;5(1):4

Diets High in Protein or Saturated Fat Do Not Affect Insulin Sensitivity or Plasma Concentrations of Lipids and Lipoproteins in Overweight and Obese Adults (2014) Chiu S, Williams PT, Dawson T, Bergman RN, Stefanovski D, Watkins SM, Krauss RM Journal of Nutrition September 3, 2014, doi: 10.3945/?jn.114.197624
 
Therapy Indications
 

Fat Quality and Incident Cardiovascular Disease, All-Cause Mortality and Cancer Mortality (2014) Rosenquist KJ, Massaro JM, Pedley A, Long MT, Kreger BE, Vasan RS, Murabito JM, Hoffmann U, Fox CS. Journal of Clinical Endocrinology & Metabolism 2014 Sep 16:jc20134296. [Epub ahead of print]

CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney. (2014) Siddiqi FS, Chen L, Advani SL, Thai K, Batchu SN, Alghamdi TA, White KE, Sood MM, Gibson IW, Connelly KA, Marsden PA, Advani A. Endocrinology. 2014 Dec 30:en20141650. [Epub ahead of print]

The Application of Multiple Reaction Monitoring to Assess Apoa-I Methionine Oxidations in Diabetes and Cardiovascular Disease (2014) Yassine HN, Jackson AM, Reaven PD, Nedelkov D, Nelson RW, Lau SS, Borchers CH Translational Proteomics

Back To Top

2013

Multiplexed protein profiling after bariatric surgery: characterization of improved endothelial dysfunction (2013) Bachmayer C, Hammes HP, Hasenberg T, Lammert A, Crowther D, Hess S Experimental and Clinical Endocrinology & Diabetes
 
Therapy Indications
 

Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders (2013) Ernst A, Sharma AN, Elased KM, Guest PC, Rahmoune H, Bahn S Transl Psychiatry. 2013 May 28;3:e263

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys (2013) Adams AC, Halstead CA, Hansen BC, Irizarry AR, Martin JA, Meyers SR, Reynolds VL, Smith HW, Wroblewski VJ, Kharitonenkov A PLoS ONE 8(6): e65763
 
Therapy Indications
 

Impaired glycemia increases disease progression in mild cognitive impairment (2013) Morris JK, Vidoni ED, Honea RA, Burns JM Neurobiology of Aging, Available online 23 October 2013

The Proton-Activated Receptor GPR4 Modulates Glucose Homeostasis by Increasing Insulin Sensitivity (2013) Giudici L, Velic A, Daryadel A, Bettoni C, Mohebbi N, Suply T, Seuwen K, Ludwig MG, Wagner CA Cell Physiol Biochem. 2013 Nov 28;32(5):1403-1416
 
Therapy Indications
 

Short sleep duration is associated with decreased serum leptin, increased energy intake, and decreased diet quality in postmenopausal women (2013) Stern JH, Grant AS, Thomson CA, Tinker L, Hale L, Brennan KM, Woods NF, Chen Z Obesity (Silver Spring). 2013 Dec 17
 
Therapy Indications
 

Leucine-Rich Repeat Kinase 2 (Lrrk2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis (2013) Ness D, Ren Z, Gardai S, Sharpnack D, Johnson VJ, Brennan RJ, Brigham EF, Olaharski AJ PLoS ONE

Back To Top

2012

Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status (2012) Pellis L, van Erk MJ, van Ommen B, Bakker GCM, Hendriks HFJ, Cnubben NHP, Kleemann R, van Someren EP, Bobeldijk I, Rubingh CM, Wopereis S Metabolomics
 
Therapy Indications
 

Evaluation of multiple variate selection methods from a biological perspective: a nutrigenomics case study (2012) Tapp HS, Radonjic M, Kate Kemsley E, Thissen U Genes Nutr. 2012 Mar 2. [Epub ahead of print]
 
Therapy Indications
 

Consumption of a High Monounsaturated-Fat Diet Reduces Oxidative Phosphorylation Gene Expression in Peripheral Blood Mononuclear Cells of Abdominally Overweight Men and Women (2012) van Dijk SJ, Feskens EJ, Bos MB, de Groot LC, de Vries JH, M?ller M, Afman LA J Nutr. 2012 May 23. [Epub ahead of print]
 
Therapy Indications
 

Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses (2012) Racioppi L, Noeldner PK, Lin F, Arvai S, Means AR J Biol Chem. 2012 Feb 14. [Epub ahead of print]
 
Therapy Indications
 

Effects of Stimulation of Soluble Guanylate Cyclase on Diabetic Nephropathy in Diabetic eNOS Knockout Mice on Top of Angiotensin II Receptor Blockade (2012) Ott IM, Alter ML, von Websky K, Kretschmer A, Tsuprykov O, Sharkovska Y, Krause-Relle K, Raila J, Henze A, Stasch JP, Hocher B PLoS One. 2012;7(8):e42623. Epub 2012 Aug 10

Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial (2012) Chiva-Blanch G, Urpi-Sarda M, Ros E, Valderas-Martinez P, Casas R, Arranz S, Guill?n M, Lamuela-Ravent?s RM, Llorach R, Andres-Lacueva C, Estruch R Clinical Nutrition (online September 3)
 
Therapy Indications
 

Blood profiling of proteins and steroids during weight maintenance with manipulation of dietary protein level and glycaemic index (2012) Wang P, Holst C, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WK, Andersen MR, van Baak MA, Rasmussen LG, Martinez JA, Jebb SA, Pfeiffer AF, Kafatos A, Handjieva-Darlenska T, Hlavaty P, Saris WH, Mariman EC Br J Nutr. 2012 Jan;107(1):106-19
 
Therapy Indications
 

Differences in the Association of Peripheral Insulin and Cognitive Function in Non-Diabetic Alzheimer's Disease Cases and Normal Controls (2012) Pavlik V, Massman P, Barber R, Doody R J Alzheimers Dis. 2012 Dec 14. [Epub ahead of print]

Plasma Lipid Profiling across Species for the Identification of Optimal Animal Models of Human Dyslipidemia (2012) Yin W, Carballo-Jane E, Mclaren DG, Mendoza VH, Gagen K, Geoghagen NS, Mcnamara LA, Gorski JN, Eiermann GJ, Petrov A, Wolff M, Tong X, Wilsie LC, Akiyama TE, Chen J, Thankappan A, Xue J, Ping X, Andrews G, Wickham LA, Gai CL, Trinh T, Kulick AA, Donnelly MJ, Voronin GO, Rosa R, Cumiskey A-M, Bekkari K, Mitnaul LJ, Puig O, Chen F, Raubertas R, Wong PH, Hansen BC, Koblan KS, Roddy TP, Hubbard BK, Strack AM Journal of Lipid Research

Back To Top

2011

Multi-Modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy (2011) VanGuilder HD, Bixler GV, Kutzler L, Brucklacher RM, Bronson SK, Kimball SR, Freeman WM PLoS ONE 6: e16271.
 
Therapy Indications
 

Blood Profile of Proteins and Steroid Hormones Predicts Weight Change after Weight Loss with Interactions of Dietary Protein Level and Glycemic Index (2011) Wang P, Holst C, Andersen MR, Astrup A, Bouwman FG, van Otterdijk S, Wodzig WKWH, van Baak MA, Larsen TM, Jebb SA, Kafatos A, Pfeiffer AFH, Martinez JA, Handjieva-Darlenska T, Kunesova M, Saris WHM, Mariman ECM PLoS ONE 6: e16773.
 
Therapy Indications
 

2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting (2011) Bouwman FG, de Roos B, Rubio-Aliaga I, Crosley LK, Duthie SJ, Mayer C, Horgan G, Polley AC, Heim C, Coort SL, Evelo CT, Mulholland F, Johnson IT, Elliott RM, Daniel H, Mariman EC BMC Med Genomics. Mar 25;4(1):24. [Epub ahead of print]
 
Therapy Indications
 

Mouse ghrelin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption (2011) Kang K, Schmahl J, Lee JM, Garcia K, Patil K, Chen A, Keene M, Murphy A, Sleeman MW FASEB J. 2011 Sep 29. [Epub ahead of print]

Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging (2011) Bailey-Downs LC, Sosnowska D, Toth P, Mitschelen M, Gautam T, Henthorn JC, Ballabh P, Koller A, Farley JA, Sonntag WE, Csiszar A, Ungvari Z J Gerontol A Biol Sci Med Sci. 2011 Nov 10. [Epub ahead of print]

G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response (2011) Gardner J, Wu S, Ling L, Danao J, Li Y, Yeh WC, Tian H, Baribault H Biochemical and Biophysical Research Communications

Biomarker analysis of Morquio syndrome: Identification of disease state and drug responsive markers (2011) Martell L, Lau K, Mei M, Burnett V, Decker C, Foehr ED Orphanet Journal of Rare Diseases 2011, 6:84
 
Therapy Indications
 

Altered Levels of Circulating Insulin and Other Neuroendocrine Hormones Associated with the Onset of Schizophrenia (2011) Guest PC, Schwarz E, Krishnamurthy D, Harris LW, Leweke FM, Rothermundt M, Van Beveren N, Spain M, Barnes A, Steiner J, Rahmoune H, Bahn S Psychoneuroendocrinology

Back To Top

2010

Metabolomics of Prolonged fasting in humans reveals new catabolic markers (2010) Rubio-Aliaga I, de Roos B, Duthie SJ, Crosley LK, Mayer C, Horgan G, Colquhoun IJ, Le Gall G, Huber F, Kremer W, Rychlik M, Wopereis S, van Ommen B, Schmidt G, Heim C, Bouwman FG, Mariman EC, Mulholland F, Johnson IT, Polley AC, Elliott RM, Daniel H Metabolomics 11 Nov 2010: online.
 
Therapy Indications
 

Plasma Protein Profiling Reveals Protein Clusters Related to BMI and Insulin Levels in Middle-Aged Overweight Subjects (2010) van Dijk SJ, Feskens EJM, Heidema AG, Bos MB, van de Rest O, Geleijnse JM, de Groot LCPGM, Muller M, Afman LA PLoS ONE 12: e14422.
 
Therapy Indications
 

Individual Differences in Hyperlipidemia and Vitamin E Status in Response to Chronic Alcohol Self-Administration in Cynomolgus Monkeys (2010) Lebold KM, Grant KA, Freeman WM, Wiren KM, Miller GW, Kiley C, Leonard SW, Traber MG Alcohol Clin Exp Res. 2010 Nov 30. [Epub ahead of print]

Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice (2010) Duval C, Thissen U, Keshtkar S, Accart B, Stienstra R, Boekschoten MV, Roskams T, Kersten S, M?ller M Diabetes. 2010 Dec;59(12):3181-91
 
Therapy Indications
 

An Antiinflammatory Dietary Mix Modulates Inflammation and Oxidative and Metabolic Stress in Overweight Men: A Nutrigenomics Approach (2010) Bakker GC, Van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, Van Ommen B, Hendriks HF The American Journal of Clinical Nutrition
 
Therapy Indications
 

Back To Top

2009

A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome (2009) van Dijk SJ, Feskens EJ, Bos MB, Hoelen DW, Heijligenberg R, Bromhaar MG, de Groot LC, de Vries JH, M?ller M, Afman LA Am J Clin Nutr. 90: 1656-64.
 
Therapy Indications
 

Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program. (2009) Radonjic M, de Haan JR, van Erk MJ, van Dijk KW, van den Berg SA, de Groot PJ, M?ller M, van Ommen B PLoS ONE 4: e6646.
 
Therapy Indications
 

Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System. (2009) Sutton SW, Shelton J, Smith C, Williams J, Yun S, Motley T, Kuei C, Bonaventure P, Gundlach A, Liu C, Lovenberg T Ann N Y Acad Sci 1160: 242-249.
 
Therapy Indications
 

Back To Top

2008

Fibroblast growth factor 21 corrects obesity in mice. (2008) Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A Endocrinology 149: 6018-6027.
 
Therapy Indications
 

Dexamethasone inhibits high glucose-, TNF-alpha-, and IL-1beta-induced secretion of inflammatory and angiogenic mediators from retinal microvascular pericytes. (2008) Nehm? A, Edelman J Invest Ophthalmol Vis Sci 49: 2030-2038.

Back To Top

2007

Lysosomal dysfunction results in altered energy balance. (2007) Woloszynek JC, Coleman T, Semenkovich CF, Sands MS J Biol Chem 282: 35765-35771.
 
Therapy Indications
 

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. (2007) Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, Hansen BC, Shanafelt AB, Etgen GJ Endocrinology 148: 774-81.
 
Therapy Indications
 

Every Order Starts With a Quote

Thank you for your interest in RBM's innovative biomarker solutions. Please tell us more about what you would like to order and provide us with your details, so we can get back to you with a quote.