Sclerostin (Sclerostin)

Sclerostin, expressed in osteocytes and some chondrocytes, inhibits bone formation by acting on osteoblasts. Humanized monoclonal antibody treatments that target sclerostin may be benificial for the treatment of osteoporosis. Sclerostin expression is impaired in patients with ankylosing spondylitis. Immunohistochemistry and western blot analysis revealed considerable overexpression of sclerostin in the synovial tissues of patients with RA compared to those with OA. Serum sclerostin is increased in individuals with prostate cancer.

Swiss-Prot Accession Number: Q9BQB4


 
Product Associations Product Associations

This analyte is not currently part of Myriad RBM's testing menu.

 
 
Therapy Indications
Bone Disease/Metabolism
 
Myriad RBM Publications Publications
Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome (2018) Lal C, Hardiman G, Kumbhare S, Strange C Sleep and Breathing
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