Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain. Three forms of ficolin have been identified in humans. Ficolin- 3 is synthesized both in the liver and in the lung. Ficolin-2 forms a complex with MASP-2 and microbial surfaces and activates the C3 convertase C4bC2b, which leads to opsonizatio and lysis of pathogens and recruitment of inflammatory cells.Low ficolin-3 serum levels have been associated with the severity and unfavorable outcome of acute ischemic stroke, insulin resistance and bacteraemia during chemotherapy.
Swiss-Prot Accession Number: O75636
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