Pentraxin-3 (PTX3) is a member of a superfamily of acute phase reactants characterized by a pentameric structure. CRP and SAP are well-characterized short pentraxins which are produced in the liver in response to inflammatory mediators. Pentraxin 3 is a long pentraxin, released by a variety of cell types including macrophages, neutrophils, myeloid-derived mesangial cells, synovial cells, smooth muscle cells, alveolar epithelium, and glial cells. PTX3 is elevated in critically ill patients, with a gradient from systematic inflammatory response syndrome to septic shock, and in several other diseases.
Swiss-Prot Accession Number: P26022