Dickkopf-related protein 1 (DKK-1)

(Dickkopf related protein 1) Member of the Dkk protein family. Secreted as a precurser protein. Inhibits Wnt pathway including LRP5/6 and beta-catenin interactions. Found to regulate joint remodeling in arthritic animal models, increased DKK-1 levels linked to bone resorption and decreased levels to new bone formation. DKK1 may play a key role in regulating pre-osteoblast differentiation and the development of multiple myeloma-associated osteolytic bone lesions. Dkks may play a role in bone diseases, Cancers & Alzheimers disease. Elevated in serum of Multiple Myeloma, Prostate cancer and Rheumatoid Arthritis patients. Decreased circulating levels found in Ankylosing Spondylitis. Possible target for theraputic treatment of Dkk-1 related diseases.

Swiss-Prot Accession Number: O94907

Therapy Indications
Myriad RBM Publications Publications
Complexity of Macrophage Migration Inhibitory Factor (MIF) and Other Angiogenic Biomarkers Profiling in Pulmonary Arterial Hypertension. (2017) Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee P, Fares W Pulm Circ.