Tyrosine kinase with Ig and EGF homology domains 1 (Tie-1)
Tyrosine kinase with Ig and EGF homology domains 1 (Tie-1) belongs to a unique tyrosine kinase subfamily. Its extracellular region is comprised of two immunoglobulin-like domains, three EGF-like domains, and three fibronectin type II-like domains. The tyrosine kinase domain is in the cytoplasmic region of the protein. Tie-1 is mainly expressed in endothelial cells and in immature hematopoietic cells. It is known to have a proinflammatory effect and is thought to play a role in inflammatory diseases like atherosclerosis. Tie-1 is involved in endothelial cell differentiation and angiogenesis.
Swiss-Prot Accession Number: P35590
Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders (2015) Ramsey JM, Guest PC, Broek JA, Glennon JC, Rommelse N, Franke B, Rahmoune H, Buitelaar JK, Bahn S. Mol Autism