Midkine is a simple, nonglycosylated protein belonging to a family of heparin binding growth and differentiation factors. Midkine is known to be expressed in endothelial cells, fetal astrocytes, kidney tumor cells, and in the senile plaques of Alzheimer’s patients. Midkine is believed to be involved in the development of the nervous system, and expression is upregulated in reparative processes such as the healing of bone fractures. It appears to enhance the angiogenic and proliferative activities of some cancers, and may be an identifier of malignancy in cancer cells.
Swiss-Prot Accession Number: P21741
Performance of a clinical/proteomic panel to predict obstructive peripheral artery disease in patients with and without diabetes (2019) McCarthy CP, Shrestha S, Ibrahim N, van Kimmenade RRJ, Gaggin HK, Mukai R, Magaret C, Barnes G, Rhyne R, Garasic JM, Januzzi JL Open Heart
A clinical and proteomics approach to predict the presense of obstructive peripheral arterial disease (From CASABLANCA) (2018) McCarthy CP, Ibrahim NE, van Kimmenade RRJ, Gaggin HK, Simon ML, Gandhi P, Kelly N, Motiwala SR, Mukai R, Magaret CA, Barnes G, Rhyne RF, Garasic JM, Januzzi JL Jr Clin Cardiol