Midkine is a simple, nonglycosylated protein belonging to a family of heparin binding growth and differentiation factors. Midkine is known to be expressed in endothelial cells, fetal astrocytes, kidney tumor cells, and in the senile plaques of Alzheimer’s patients. Midkine is believed to be involved in the development of the nervous system, and expression is upregulated in reparative processes such as the healing of bone fractures. It appears to enhance the angiogenic and proliferative activities of some cancers, and may be an identifier of malignancy in cancer cells.
Swiss-Prot Accession Number: P21741