Decorin (Decorin)

Decorin is a ubiquitous pericellular matrix proteoglycan. It belongs to the small leucine-rich proteoglycan (SLRP) family, and is produced mainly by cells of mesenchymal origin. It consists of a core protein covalently linked to a glycosaminoglycan chain which is either chondroitin or dermatan sulfate. Decorin is known to interact with fibronectin, TGF-?, and collagen types I and II. It plays various roles in matrix assembly, cell adhesion, cell migration, and growth. Decorin is known to adversely affect the growth of various cancer types by downregulating the activity of receptors involved in cell growth and survival and by sequestering TGF-? through binding.

Swiss-Prot Accession Number: P07585

Therapy Indications
Myriad RBM Publications Publications
A phase 1b trial of the CXCR4 inhibitor mavorixafor and nivolumab in advanced renal cell carcinoma patients with no prior response to nivolumab monotherapy (2021) Choueiri TK, Atkins MB, Rose TL, Alter RS, Yawen J, Niland K, Wang Y, Arbeit R, Parasuraman S, Gan L, McDermott DF Investigational New Drugs
Distinct patterns of blood cytokines beyond a cytokine storm predict mortality in COVID-19 (2021) Herr C, Mang S, Mozafari B, Guenther K, Speer T, seibert M, Srikakulam SK, Beisswenger C, Ritzmann F, Keller A, Mueller R, smola S, Eisinger D, Zemlin M, Danziger G, Volk T, Hoersch S, Krawczyk M, Lammert F, Adams T, Wagenpfeil G, Kindermann M, Marcu C, Ataya ZWD, Mittag M, Schwarzkopf K, Custodis F, Grandt D, Schaefer H, Eltges K, Lepper PM, Bals R Journal of Inflammation Research
Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts. (2016) Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JL, Rennard SI, Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine Iii R, Martinez FJ, Bowler RP, O'Neal WK; for COPDGene and SPIROMICS Investigators. Am J Respir Crit Care Med.