Carbonic anhydrase 9 (CA-9)

Carbonic Anhydrase 9 (CA-9) is a transmembrane enzyme expressed primarily in carcinoma cells and is one of the best markers for hypoxia and renal cell carcinoma. It catalyzes the reversible hydration of carbon dioxide, which is fundamental to many processes such as respiration, renal tubular acidification, and bone resorption. CA-9 is upregulated in many types of tumors including renal cell carcinoma, non-small cell lung carcinoma, ovarian cancer, breast cancer, and cervical cancer.

Swiss-Prot Accession Number: Q16790

Therapy Indications
Myriad RBM Publications Publications
Distinct patterns of blood cytokines beyond a cytokine storm predict mortality in COVID-19 (2021) Herr C, Mang S, Mozafari B, Guenther K, Speer T, seibert M, Srikakulam SK, Beisswenger C, Ritzmann F, Keller A, Mueller R, smola S, Eisinger D, Zemlin M, Danziger G, Volk T, Hoersch S, Krawczyk M, Lammert F, Adams T, Wagenpfeil G, Kindermann M, Marcu C, Ataya ZWD, Mittag M, Schwarzkopf K, Custodis F, Grandt D, Schaefer H, Eltges K, Lepper PM, Bals R Journal of Inflammation Research
Circulating Biomarkers and Outcome from a Randomised Phase Ii Trial of Sunitinib Vs Everolimus for Patients with Metastatic Renal Cell Carcinoma (2016) Voss MH, Chen D, Marker M, Hakimi AA, Lee C-H, Hsieh JJ, Knox JJ, Voi M, Motzer RJ British Journal of Cancer