Beta Amyloid 1-42 (AB-42)

Beta Amyloid, also known as Abeta, (Aß42) is a peptide of 36–43 amino acids that appears to be the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. The most common isoforms are AB-40 and AB-42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The AB-40 form is the more common of the two, but AB-42 is the more fibrillogenic and is thus associated with disease states.

Swiss-Prot Accession Number: P05067

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This analyte is not currently part of Myriad RBM's testing menu.

Myriad RBM Publications Publications
Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition (2021) Tubi MA, Kothapalli D, Hapenney M, Feingold FW, Mack WJ, King KS, Thompson PM, Braskie MN Neurobiology of Aging
A comprehensive systematic review of CSF proteins and peptides that define Alzheimer’s disease (2020) Pedrero-Prieto CM, Garcia-Carpintero S, Frontinan-Rubio J,Llanos-Gonzalez E, Aguilera Garcia C, Alcain FJ, Lindberg I, Duran-Prado M, Peinado J, Rabanal-Ruiz Y Clinical Proteomics