Beta Amyloid 1-40 (AB-40)
Beta Amyloid, also known as Abeta, (Aß40) is a peptide of 36-43 amino acids that appears to be the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. The most common isoforms are AB-40 and AB-42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The AB-40 form is the more common of the two, but AB-42 is the more fibrillogenic and therefore associated with disease states.
Swiss-Prot Accession Number: P05067