Cadherin-13 (T-cad)

Cadherin-13 (T-cad) is a unique member of the cadherin superfamily because it lacks the transmembrane and cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. The distribution of T-cad in the cell membrane is restricted to lipid rafts where it co-localizes with signal-transducing molecules, suggesting T-cad acts in intracellular signaling rather than adhesion. LDL and high-molecular weight (HMW) complexes of adiponectin are known ligands. T-cad loss in tumor cells is associated with tumor malignancy, invasiveness, and metastasis.

Swiss-Prot Accession Number: P55290


 
Product Associations Product Associations

This analyte is not currently part of Myriad RBM's testing menu.

 
 
Therapy Indications
Cancer
 
Myriad RBM Publications Publications
Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study (2016) Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AH, Bartlett A, Kissel JT Ann Clin Transl Neurol
The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes (2014) Carolan BJ, Hughes G, Morrow J, Hersh CP, O'Neal WK, Rennard S, Pillai SG, Belloni P, Cockayne DA, Comellas AP, Han M, Zemans RL, Kechris K, Bowler RP. Respiratory Research 2014 Oct 12;15(1):127. doi: 10.1186/s12931-014-0127-9.
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