Dipeptidyl peptidase IV (DPPIV)

Dipeptidyl peptidase-4 (DPP4), also known as CD26, is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction, and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Its substrates include growth factors, chemokines, neuropeptides and vasoactive peptides. DPP-4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1.

Swiss-Prot Accession Number: P27487


 
Product Associations Product Associations

This analyte is not currently part of Myriad RBM's testing menu.

 
 
Therapy Indications
Cancer
Diabetes, Lipid and Carbohydrate Metabolism
 
Myriad RBM Publications Publications
Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study (2016) Kolb SJ, Coffey CS, Yankey JW, Krosschell K, Arnold WD, Rutkove SB, Swoboda KJ, Reyna SP, Sakonju A, Darras BT, Shell R, Kuntz N, Castro D, Iannaccone ST, Parsons J, Connolly AM, Chiriboga CA, McDonald C, Burnette WB, Werner K, Thangarajh M, Shieh PB, Finanger E, Cudkowicz ME, McGovern MM, McNeil DE, Finkel R, Kaye E, Kingsley A, Renusch SR, McGovern VL, Wang X, Zaworski PG, Prior TW, Burghes AH, Bartlett A, Kissel JT Ann Clin Transl Neurol
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