Cadherin-1 (E-Cad) is a member of the cadherin superfamily. Cadherins are transmembrane proteins that play an important role in cell adhesion, ensuring the cells within the tissue are bound together maintaining their integrity. To function, cadherins are dependent on calcium ions. Studies have shown that reduction and/or loss of E-cad expression in carcinomas correlates positively with the potential of tumors for invasion and metastasis.
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Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension. (2017) Nishida K, Brune KA, Putcha N, Mandke P, O'Neal WK, Shade D, Srivastava V, Wang M, Lam H, An SS, Drummond MB, Hansel NN, Robinson DN, Sidhaye VK. Am J Physiol Lung Cell Mol Physiol