Tyrosine kinase with Ig and EGF homology domains 2 (TIE-2)
Tyrosine kinase with Ig and EGF homology domains 2 (TIE-2) is a receptor tyrosine kinase that is expressed primarily on endothelial cells and plays a critical role in vascular development. The ligands for TIE-2 include angiopoietins (Ang) -1, -2, -3 and -4. Soluble TIE-2 plays a role in angiogenesis.
Swiss-Prot Accession Number: Q02763
PublicationsDendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Prognostic/predictive value of 207 serum factors in colorectal cancer treated with cediranib and/or chemotherapy (2013) Spencer SK, Pommier AJ, Morgan SR, Barry ST, Robertson JD, Hoff PM, J?rgensmeier JM Br J Cancer. 2013 Oct 22