Platelet basic protein (PBP, CXCL7), which is found in the alpha-granules of human platelets is proteolytically cleaved to form Neutrophil activating peptide 2 (NAP-2), connective tissue activating protein III (CTAP-III) and beta-thrombogulin (beta-TG). NAP-2 binds CXCR2 and chemoattracts and activates neutrophils. Serum NAP-2 is increased in lung and hepatic cancers.
Peripheral lymphocyte signaling pathway deficiencies predict treatment response in first-onset drug-naïve schizophrenia (2022) Santiago G. Lago, Jakub Tomasik, Geertje F. Rees, Nitin Rustogi, Javier Vazquez-Bourgon, Sergi Papiol, Paula Suarez-Pinilla, Benedicto Crespo-Facorro, Sabine Bahn Brain Behavior and Immunity
Amygdalar activity predicts future incident diabetes independently of adiposity (2019) Osborne MT, Ishai A, Hammad B, Tung B, Wang Y, Baruch A, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A Psychoneuroendocrinology