Latency-Associated Peptide of Transforming Growth Factor beta 1

Latency-Associated Peptide of Transforming Growth Factor beta 1 (LAP TGF-b1)

LAP TGF-b1 assay detects human LAP TGF-b1 and Latent TGF-b1, but not active/free TGF- b1, The assay is a good surrogate biomarker for free TGF-b1. Measuring the total amount of free TGF-b1 requires acidification and neutralization of samples to release free TGF-b1 from LAP and LTBP. Free TGF-b1 is transient, does not circulate and is meant to act locally (autocrine and paracrine factor) upon activation of LAP TGF-b1. Latency Associated Peptide (LAP) is derived from the N-terminal region of the TGF-b1 propeptide and is bound to TGF-b1 to form a complex called Small Latent Complex (SLC). This complex remains in the cell until it is bound by another protein called Latent TGF-ß-Binding Protein (LTBP), forming a larger complex called Large Latent Complex (LLC) that can be secreted. TGF-b1 is a multifunctional regulatory cytokine and growth factor controlling cell division, development, homeostasis, apoptosis, and the immune system.

Swiss-Prot Accession Number: P01137

Publications

A phase 1b trial of the CXCR4 inhibitor mavorixafor and nivolumab in advanced renal cell carcinoma patients with no prior response to nivolumab monotherapy (2021) Choueiri TK, Atkins MB, Rose TL, Alter RS, Yawen J, Niland K, Wang Y, Arbeit R, Parasuraman S, Gan L, McDermott DF Investigational New Drugs

Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One

Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports