Vascular endothelial growth factor B (VEGF-B)
Vascular endothelial growth factor B (VEGF-B) is a member of the VEGF family of growth factors that share structural and functional similarity. Five mammalian members, including VEGF-A, -B, -C, -D and PlGF have been identified. VEGF-B is expressed in most tissues, especially in heart, skeletal muscle, and pancreas. In many tissues, VEGF-B is a homodimer but can heterodimerize with VEGF-A. Two isoforms of mature VEGF-B containing 167 or 186 amino acid (aa) residues exist. Whereas VEGF-B186 is a secreted diffusible protein, VEGF-B167 is sequestered into the cell matrix after secretion. Both VEGF-B isoforms bind VEGF receptor 1 (VEGF R1) but not VEGF R2 or VEGF R3. VEGF-B can also bind Neuropilin-1.
Swiss-Prot Accession Number: P49765