Serum pepsinogen (PGI) consists of two biochemically and immunologically distinct types, namely, pepsinogen I and pepsinogen II (Pepsinogen C). PGI is produced by chief and mucous neck cells in the fundic glands, while PGII is produced by these cells and cells in the pyloric and Brunner’s glands. PGI is decreased in atrophic gastritis and gastric cancer patients compared with healthy controls and patients with gastric or duodenal ulcers. PGI may be a useful screening tool for gastric cancer.
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