Pepsinogen I (PGI)

Serum pepsinogen (PGI) consists of two biochemically and immunologically distinct types, namely, pepsinogen I and pepsinogen II (Pepsinogen C). PGI is produced by chief and mucous neck cells in the fundic glands, while PGII is produced by these cells and cells in the pyloric and Brunner?s glands. PGI is decreased in atrophic gastritis and gastric cancer patients compared with healthy controls and patients with gastric or duodenal ulcers. PGI may be a useful screening tool for gastric cancer.

Swiss-Prot Accession Number: O95576

Therapy Indications
Myriad RBM Publications Publications
Identification of Novel Causal Blood Biomarkers Linking Metabolically Favorable Adiposity With Type 2 Diabetes Risk (2019) Pigeyre M, Sjaarda J, Mao S, Chong M, Hess S, Yusuf S, Gerstein H, Pare G Diabetes Care
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports