Stromal cell-derived factor-1 (SDF-1)
Stromal cell-derived factor-1 (SDF-1; CXCL12) has two forms, SDF-1 alpha and SDF-1 beta. They are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the additional four amino acids present in the carboxy-terminus of SDF-1 beta. SDF-1 is a chemoattractant for T-lymphocytes and monocytes, but not neutrophils. SDF-1 is a ligand for the CXCR4 receptor that functions as a co-receptor for lymphocytetropic HIV-1 strains and plays a role in the inhibition of infection in HIV.
Swiss-Prot Accession Number: P48061
PublicationsPeripheral lymphocyte signaling pathway deficiencies predict treatment response in first-onset drug-na?ve schizophrenia (2022) Santiago G. Lago, Jakub Tomasik, Geertje F. Rees, Nitin Rustogi, Javier Vazquez-Bourgon, Sergi Papiol, Paula Suarez-Pinilla, Benedicto Crespo-Facorro, Sabine Bahn Brain Behavior and Immunity
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease (2021) Pierson SK, Shenoy S, Oromendia AB, Gorzewski AM, Pai RA, Nabel CS, Ruth JR, parente SAT, Arenas DJ, Guilfoyle M, Reddy MP, Weinblatt M, Shadick N, Bower M, Pria AD, Masaki Y, Katz L, Mezey J, Beineke P, Lee D, Tendler C, Kambayashi T, Fossa A, van Rhee F, Fajgenbaum DC Blood Advances
Biomarker signature in cancer patients with and without venous thromboembolism events: a substudy of CASSINI (2021) Khorana A, Barnard J, Wun T, Vijapurkar U, Damaraju CV, Moore K, Wildgoose P, McCrae K Blood Advances
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Phase Ib Study of Glasdegib, A Hedgehog Pathway Inhibitor, in (2018) Savona M, Pollyea D, Stock W, Oehler V, Schroeder MA, Lancet J, McCloskey J, Kantarigian H, Ma WW, Shaik MN, Laird AD, Zeremski M, O'Connell A, Chan G, Cortes JE Clinical Cancer Research
Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease (2018) Sjaarda J, Gerstein H, Chong M, Yusuf S, Meyre D, Anand SS, Hess S, Pare G Journal of the American College of Cardiology
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports