Stromal cell-derived factor-1 (SDF-1)

Stromal cell-derived factor-1 (SDF-1; CXCL12) has two forms, SDF-1 alpha and SDF-1 beta. They are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the additional four amino acids present in the carboxy-terminus of SDF-1 beta. SDF-1 is a chemoattractant for T-lymphocytes and monocytes, but not neutrophils. SDF-1 is a ligand for the CXCR4 receptor that functions as a co-receptor for lymphocytetropic HIV-1 strains and plays a role in the inhibition of infection in HIV.

Swiss-Prot Accession Number: P48061

Therapy Indications
Myriad RBM Publications Publications
Phase Ib Study of Glasdegib, A Hedgehog Pathway Inhibitor, in (2018) Savona M, Pollyea D, Stock W, Oehler V, Schroeder MA, Lancet J, McCloskey J, Kantarigian H, Ma WW, Shaik MN, Laird AD, Zeremski M, O'Connell A, Chan G, Cortes JE Clinical Cancer Research
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Blood CSF1 and CXCL12 as Causal Mediators of Coronary Artery Disease (2018) Sjaarda J, Gerstein H, Chong M, Yusuf S, Meyre D, Anand SS, Hess S, Pare G Journal of the American College of Cardiology
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports