Endoglin (Endoglin)

Endoglin is a major glycoprotein of vascular endothelium. It plays an important role in angiogenesis, hematopoiesis, and heart development. Endoglin complexes with signaling receptor TGF-beta and also helps to regulate binding of endothelial cells to integrins and other RGD receptors. Endoglin is expressed in vascular endothelium, chondrocytes and blast cells of term placenta, as well as early stage or activated blood cells. Expression is upregulated during angiogenesis, wound healing, and dermal inflammation. Endoglin has been successfully used as a marker to identify repopulating hematopoietic stem cells.

Swiss-Prot Accession Number: P17813


 
Therapy Indications
Cancer
Cardiac and Vascular Markers/Disease
 
Myriad RBM Publications Publications
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Blood-based immune-endocrine biomarkers of treatment response in depression (2016) Chan MK, Cooper JD, Bot M, Birkenhanger TK, Bergink V, Drexhage HA, Steiner J, Rothermundt M, Penninx BWJH, Bahn S Journal of Psychiatric Research
A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. (2016) Jimeno A, Posner MR, Wirth LJ, Saba NF, Cohen RB, Popa EC, Argiris A, Grossmann KF, Sukari A, Wilson D, Zhang X, Sun J, Glasser C, Attie KM, Sherman ML, Pandya SS, Weiss J. Cancer
Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre-eclampsia in a low-risk nulliparous patient population? (2013) Myatt L, Clifton R, Roberts J, Spong C, Wapner R, Thorp J Jr, Mercer B, Peaceman A, Ramin S, Carpenter M, Sciscione A, Tolosa J, Saade G, Sorokin Y, Anderson G; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network BJOG. 2013 Jan 18
Speak to a Scientist