Vascular Endothelial Growth Factor C (VEGF-C)

Vascular Endothelial Growth Factor C (VEGF-C) is active in angiogenesis and endothelial cell growth. It has roles in the venous and lymphatic vascular systems during embryogenesis and also in the maintenance of differentiated lymphatic endothelium in adults. It functions in angiogenesis of the venous and lymphatic vascular systems during embryogenesis and in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. VEGF-C is found in spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon, small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. VEGF-C undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3. Only the fully processed form can activate VEGFR-2. VEGF-C first forms an antiparallel homodimer linked by disulfide bonds but before secretion, a cleavage occurs between Arg-227 and Ser-228 producing an heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.

Swiss-Prot Accession Number: P49767


 
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This analyte is not currently part of Myriad RBM's testing menu.

 
Myriad RBM Publications Publications
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer. (2017) Yeh CY, Adusumilli R, Kullolli M, Mallick P, John EM, Pitteri SJ Biomark Res.
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports
Angiogenesis Dysregulation in Term Asphyxiated Newborns Treated with Hypothermia (2015) Shaikh H, Boudes E, Khoja Z, Shevell M, Wintermark P PLOS One