Interferon gamma Induced Protein 10, short (IP-10, short)

Interferon gamma Induced Protein 10 (IP-10; 10kDa interferon-gamma-induced protein; CXCL10) is induced in a variety of cells in response to IFN-gamma. IP-10 inhibits bone marrow colony formation and angiogenesis, stimulates NK and T cell migration, regulates T cell maturation and modulates adhesion molecule expression. IP-10 induction to be involved in many disorders including autoimmune diseases, kidney injury, cancer and importantly, infectious diseases such as hepatitis C. For hepatitis C patients, measurement of the short and long forms have been used to predict the response to therapy. IP-10 is cleaved by the enzyme dipeptidyl peptidase IV (DPP4), resulting in increased amounts of the truncated (short) form of the protein that exhibits lower biological activity.

Swiss-Prot Accession Number: P02778

Myriad RBM Publications Publications
CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients (2013) Ragab D, Laird M, Duffy D, Casrouge A, Mamdouh R, Abass A, Shenawy DE, Shebl AM, Elkashef WF, Zalata KR, Kamal M, Esmat G, Bonnard P, Fontanet A, Rafik M, Albert ML Cytokine. 2013 May 7. pii: S1043-4666(13)00181-6
Discrimination of agonist and antagonist forms of CXCL10 in biologic samples (2011) Casrouge A, Bisiaux A, Stephen L, Schmolz M, Mapes J, Pfister C, Pol S, Mallet V, Albert ML Clin Exp Immunol. 2012 Jan;167(1):137-48