Human Epidermal Growth Factor Receptor 2 (HER-2)

Human Epidermal Growth Factor Receptor 2 (HER-2, Neu) activates a number of signaling pathways including MAPK, phospholipase C gamma, and protein kinase C. HER-2 is a member of a family of receptors that promote cell proliferation and oppose apoptosis. It has been shown to play an important role in the progression of specific, aggressive types of breast cancer and now serves as a biomarker and therapeutic target.

Swiss-Prot Accession Number: P04626

Therapy Indications
Myriad RBM Publications Publications
Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment (2018) van den Ham HJ, Cooper J, Tomasik J, Bahn S, Aerts J, Oseterhaus A, Gruters R, Andeweg A PLoS One
Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports